7 research outputs found
Nanoscale organization of the normal human dermal fibroblasts and mesenchymal stem cells isolated from adipose tissue
Evidence of surface structure of the cultured astrocytes and glioblastoma cell culture after exposing Ξ²-amyloids (AΞ²1-40, AΞ²1-42, tau-protein) isolated from the aged human brain with Alzheimer's disease
Differentiation markers of neurodegeneration (AΞ²40, AΞ²42, PrP27-30) in Alzheimer's disease and prion diseases on the designed silicon biochips
Π ΡΠ°Π±ΠΎΡΠ΅ ΠΏΡΠ΅Π΄ΡΡΠ°Π²Π»Π΅Π½Ρ ΡΠ΅Π·ΡΠ»ΡΡΠ°ΡΡ ΡΠΊΡΠΏΠ΅ΡΠΈΠΌΠ΅Π½ΡΠ°Π»ΡΠ½ΡΡ
ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΠΉ ΠΏΠΎ ΠΊΠΎΠ½ΡΡΡΡΠΈΡΠΎΠ²Π°Π½ΠΈΡ Π½Π°Π½ΠΎΡΠ΅Ρ
Π½ΠΎΠ»ΠΎΠ³ΠΈΡΠ΅ΡΠΊΠΈΡ
ΠΏΠ»Π°ΡΡΠΎΡΠΌ Π΄Π»Ρ ΡΠΏΡΠ°Π²Π»ΡΠ΅ΠΌΠΎΠΉ Π°Π΄ΡΠΎΡΠ±ΡΠΈΠΈ, Π΄Π΅ΡΠ΅ΠΊΡΠΈΠΈ ΠΈ ΠΈΠ΄Π΅Π½ΡΠΈΡΠΈΠΊΠ°ΡΠΈΠΈ Ρ ΠΈΡΠΏΠΎΠ»ΡΠ·ΠΎΠ²Π°Π½ΠΈΠ΅ΠΌ Π°ΡΠΎΠΌΠ½ΠΎ-ΡΠΈΠ»ΠΎΠ²ΠΎΠΉ ΠΌΠΈΠΊΡΠΎΡΠΊΠΎΠΏΠΈΠΈ ΠΌΠ°ΡΠΊΠ΅ΡΠΎΠ² Π½Π΅ΠΉΡΠΎΠ΄Π΅Π³Π΅Π½Π΅ΡΠ°ΡΠΈΠΈ β Ξ²-Π°ΠΌΠΈΠ»ΠΎΠΈΠ΄ΠΎΠ² ΠΞ²40, AΞ²42, ΠΏΡΠΈΠΎΠ½Π½ΠΎΠ³ΠΎ PrP27-30 Π±Π΅Π»ΠΊΠ°. ΠΠΎΠ»ΡΡΠ΅Π½Π½ΡΠ΅ ΡΠ΅Π·ΡΠ»ΡΡΠ°ΡΡ Π²Π°ΠΆΠ½Ρ Π΄Π»Ρ ΠΎΡΠ΅Π½ΠΊΠΈ ΡΡΠ΅ΠΏΠ΅Π½ΠΈ Π²ΡΡΠ°ΠΆΠ΅Π½Π½ΠΎΡΡΠΈ Π΄Π΅Π³Π΅Π½Π΅ΡΠ°ΡΠΈΠ²Π½ΠΎ-Π΄ΠΈΡΡΡΠΎΡΠΈΡΠ΅ΡΠΊΠΈΡ
ΠΈΠ·ΠΌΠ΅Π½Π΅Π½ΠΈΠΉ Π² Π¦ΠΠ‘, ΡΡΠΎΠ²Π΅ΡΡΠ΅Π½ΡΡΠ²ΠΎΠ²Π°Π½ΠΈΡ ΠΌΠ΅ΡΠΎΠ΄ΠΎΠ² Π΄ΠΈΠ°Π³Π½ΠΎΡΡΠΈΠΊΠΈ ΠΈ ΠΏΡΠΎΠ³Π½ΠΎΠ·ΠΈΡΠΎΠ²Π°Π½ΠΈΡ ΡΠΊΠΎΡΠΎΡΡΠΈ ΡΠ°Π·Π²ΠΈΡΠΈΡ ΠΏΠ°ΡΠΎΠ»ΠΎΠ³ΠΈΡΠ΅ΡΠΊΠΎΠ³ΠΎ ΠΏΡΠΎΡΠ΅ΡΡΠ° Π² Π·Π°Π²ΠΈΡΠΈΠΌΠΎΡΡΠΈ ΠΎΡ ΠΊΠΎΠ½ΡΠ΅Π½ΡΡΠ°ΡΠΈΠΈ ΠΈ ΠΊΠΎΠ½ΡΠΎΡΠΌΠ°ΡΠΈΠΎΠ½Π½ΠΎΠΉ ΡΡΡΡΠΊΡΡΡΡ Π°ΠΌΠΈΠ»ΠΎΠΈΠ΄ΠΎΠ³Π΅Π½Π½ΡΡ
Π±Π΅Π»ΠΊΠΎΠ².The article presents the experimental results on design of nanotechnological platforms for controlled adsorption, detection and identification using atomic force microscopy markers of the neurodegeneration β Ξ²-amyloids Ξ²40, Ξ²42, prion PrP27-30 protein. The obtained results are important for assessing the severity of degenerative-dystrophic changes in the central nervous system, improving the methods for diagnosis and predicting the rate of development of the pathological process, depending on the concentration and conformational structure of amyloidogenic proteins