Ocular morbidity among diabetics attending the preventive ophthalmic clinic of a tertiary care institute with special reference to diabetic retinopathy

Background: Non communicable diseases have taken over previously life threatening infections in the demographic transition. As the burden of NCDs including diabetes is increasing at an alarming rate the complications related to these diseases are also increasing leading to huge morbidity. Likewise, blindness/ visual impairment due to diabetic retinopathy is now slowly and steadily replacing refractive errors and cataracts as a cause of morbidity.Methods: This cross sectional study was carried over a period of one year in an ophthalmic unit of a tertiary health care institute in which known diabetic patients were screened for diabetic retinopathy besides various modifiable and non-modifiable risk factors.Results: Overall prevalence of diabetic retinopathy in our study population was found to be 29.0%. Among various risk factors duration of diabetes, hypertension, HbA1C >6.5% and serum creatinine >1.1 mg/dl were found to be significantly associated with diabetic retinopathy.Conclusion: Regular screening for diabetic retinopathy besides prevention and strict control of risk factors is key to prevention and progression of blindness/ visual impairment due to diabetic retinopathy

Diagnostic Relevance of Primary Investigations in Early Referral and Management of Colorectal Cancer Patients

Aim: Colorectal cancers are largely considered as curable yet the high mortality rates associated with it points out at deficiency in early management of the disease. The aim of this study was to analyze the diagnostic potential of routine primary investigations with an attempt to categorize symptoms for early referral of colorectal cancers patients.Methods: This study involved retrospective analysis of a cohort of 85 patients diagnosed with colorectal cancer that underwent surgery in a period of one year. The patients were arranged into different age-groups to analyze the relative incidence and prognosis of the disease with respect to generalized symptoms and clinicopathological details. Multinomial Logistic Regression analysis was employed to predict the most effective set of parameter combinations for primary prognosis of the diseased state.Results: Abdominal pain, rectal bleeding and change in bowel habits were predominantly reported symptoms; however, these were imprecise with age, sex or stage of cancer. Interestingly, almost 85% of the patients were reported anemic, with a majority of them (41.7%) having Hb 10. Anaemic patients showed significantly higher frequency of symptoms viz. change in bowel habits (p 0.023), rectal bleeding (p 0.035) and/or abdominal pain (p 0.039) compared to non-anaemic ones. The co-occurrence of any two of the symptoms further increased the likelihood of the disease in anaemic patients.Conclusion: A substantial decrease in hemoglobin count with concomitant change in bowel habits, rectal bleeding, and/or abdominal pain could be considered as potential referral markers for early management of suspected colorectal cancers patients

Eco-friendly dyeing of wool and pashmina fabric using Quercus robur L. (fruit cups) dye and Salix alba L. (wood extract) mordant

Study was conducted to investigate the dyeing potential of Quercus robur L. (fruit cups) dye and Salix alba L. (wood extract) mordant on wool and pashmina fabrics. The experiment was conducted keeping in view the environmental safety by using unutilized plant materials and excluding the usage of chemical agents. The dyeing was carried out individually including and excluding mordant adopting different mordanting methods. The parameters like percent absorption, colour coordinates, colour strength (K/S), relative colour strength and colour fastness with regard to washing, light and rubbing were investigated. The results revealed higher percent absorption of mordanted samples than unmordanted samples. Colour coordinates (L*a*b*, Chroma, hue and ?E) of dyed wool and pashmina fabric exhibited satisfactory results. The colour strength (K/S) and relative colour strength of pashmina fabric recorded higher than wool fabric. The fastness properties to washing, light and rubbing showed satisfactory grades including and excluding natural mordant. However, the grades of mordanted samples were found better than unmordanted samples. The dye and mordant in isolation and in combination showed beautiful colours and shades on selected fabrics with satisfactory retention properties, hence can be utilized commercially for coloration of wool and pashmina fabrics

Genotypic and morphological diversity analysis in high altitude maize (Zea mays L.) inbreds under Himalayan temperate ecologies

The present investigation was carried out to generate information on genetic divergence of maize (Zea mays L.) inbreds and to identify elite lines to develop potential hybrids for high altitude ecologies. Data were recorded for thirteen (13) quantitative traits viz. germination (%), root depth, shoot length, days to 50 % pollen shed, days to 50% silking, plant height, ear height, ear length, ear girth, number of kernels per row, 100 seed weight, grain yield per plant. The tested genotypes expressed significant variability with high estimates of heritability (broad sense) for all the traits revealing that these traits are amenable to genetic improvement. Grain yield per plant exhibited positive and significant correlation with plant height, ear height, ear width, number of kernels per row, number of kernel rows and 100 seed weight at both the levels which exhibit a strong possibility for improvement of grain yield per plant by selection for these traits. Genetic divergence based on thirteen quantitative traits grouped thirty maize inbred lines into four clusters as per Mahalanobis D2 analysis employing Tocher’s method which revealed wide diversity in elite genotypes owing to the involvement of diverse parental lines in the hybridization programme. Grain yield per hectare was the main factor contributing to total divergence (41.16%) which needs to be considered for highlighting clusters to be chosen for the purpose of further selection

Dissection of paracrine/autocrine interplay in lung tumor microenvironment mimicking cancer cell-monocyte co-culture models reveals proteins that promote inflammation and metastasis

Abstract Background Tumor cell-monocyte interactions play crucial roles in shaping up the pro-tumorigenic phenotype and functional output of tumor-associated macrophages. Within the tumor microenvironment, such heterotypic cell–cell interactions are known to occur via secretory proteins. Secretory proteins establish a diabolic liaison between tumor cells and monocytes, leading to their recruitment, subsequent polarization and consequent tumor progression. Methods We co-cultured model lung adenocarcinoma cell line A549 with model monocytes, THP-1 to delineate the interactions between them. The levels of prototypical pro-inflammatory cytokines like TNF-, IL-6 and anti-inflammatory cytokines like IL-10 were measured by ELISA. Migration, invasion and attachment independence of lung cancer cells was assessed by wound healing, transwell invasion and colony formation assays respectively. The status of EMT was evaluated by immunofluorescence. Identification of secretory proteins differentially expressed in monocultures and co-culture was carried out using SILAC LC–MS/MS. Various insilico tools like Cytoscape, Reacfoam, CHAT and Kaplan–Meier plotter were utilized for association studies, pathway analysis, functional classification, cancer hallmark relevance and predicting the prognostic potential of the candidate secretory proteins respectively. Results Co-culture of A549 and THP-1 cells in 1:10 ratio showed early release of prototypical pro-inflammatory cytokines TNF- and IL-6, however anti-inflammatory cytokine, IL-10 was observed to be released at the highest time point. The conditioned medium obtained from this co-culture ratio promoted the migration, invasion and colony formation as well as the EMT of A549 cells. Co-culturing of A549 with THP-1 cells modulated the secretion of proteins involved in cell proliferation, migration, invasion, EMT, inflammation, angiogenesis and inhibition of apoptosis. Among these proteins Versican, Tetranectin, IGFBP2, TUBB4B, C2 and IFI30 were found to correlate with the inflammatory and pro-metastatic milieu observed in our experimental setup. Furthermore, dysregulated expression of these proteins was found to be associated with poor prognosis and negative disease outcomes in lung adenocarcinoma compared to other cancer types. Pharmacological interventions targeting these proteins may serve as useful therapeutic approaches in lung adenocarcinoma. Conclusion In this study, we have demonstrated that the lung cancer cell-monocyte cross-talk modulates the secretion of IFI30, RNH1, CLEC3B, VCAN, IGFBP2, C2 and TUBB4B favoring tumor growth and metastasis

<i style="">Pashmina shawl</i> - A traditional way of making in Kashmir

329-333Since centuries, the handicraft industry is running successfully in beautiful valley of Kashmir. Among handicrafts, shawl industry has gained popularity all over the world for the way these shawls are being prepared. Shawl making in Kashmir is an age old practice over which the artisans have expertise themselves over generations. The shawls prepared from Pashmina fibre are liked by all irrespective of their age, sex and nation. From ages, Pashmina shawls are being prepared in the valley by traditional methods. The objective of the study was to ascertain the processing methodology adapted by local artisans in Kashmir Valley for shawl preparation. In this paper, the processing of Pashmina from fibre to the final product (shawl) right from harvesting up to finishing is presented in detail

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Not AvailablePashmina, a finest natural animal fiber is utilized for preparation of world famous Kashmiri pashmina shawls by traditional practices. Hand spinning is one of the important processing step, wherein fibers are converted into a fine yarn on a traditional spinning wheel (yander). The task is usually carried out by women folk. It is a labo-rious process resulting in a lot of physical stress affecting the efficiency of artisans. An innovative charkha has been fabricated to reduce the physical stress and its effect on the spinning efficiency and remuneration of artisans over traditional one was evaluated. The study revealed that innovative charkha was efficient in terms of time consumed for spinning by 73.50% over traditional one besides decreasing physical drudgery. In terms of in-come, there was an increase of 146% over traditional one for same period of time without deteriorating the quality of yarn.Not Availabl

Comparative study on quality of shawls made from hand-and machine-spun pashmina yarns

224-230An attempt has been made to compare the quality of pashmina shawls developed on traditional and woollen handlooms using both hand-spun and machine-spun yarns for various physico-mechanical parameters. The experimental plan includes preparation of both hand-spun and machine-spun yarns followed by the preparation of pashmina shawls from these yarns on both traditional and woollen handlooms, and their quality evaluation. Number of fibres/cross-section, count, elongation percentage, tenacity and coefficient of friction show significant difference between hand-spun and machine-spun yarns. The quality evaluation tests of fabrics reveal that weight/m2, thickness, picks/inch, extension percentage, bending rigidity, frictional properties and total hand value show significant difference, whereas ends/inch, breaking load, tenacity, bending length, abrasion loss and shrinkage loss do not show significant difference. The study reveals that the overall quality of pashmina shawls developed on traditional loom using hand-spun yarn is better than the other types of shawls developed and studied

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Not AvailableA study was conducted to compare the quality of Pashmina fibre dehaired manually and mechanically. Pashmina was procured from All Changthangi Pashmina Growers Association, Leh, Ladakh. Samples were drawn randomly from different bales. The total Pashmina sample was divided into tow parts. Half of the Pashmina was dehaired manually while remaining half was dehaired on machine. Both types of pashmina fibres were evaluated for fineness, length, bundle strength, coefficient of friction and scanning electronic imaging (SEM). Fibre diameter and bundle strength showed non-significant difference whereas fibre length and co-efficient of friction showed significant difference (P<0.05) between the dehairing methods. SEM images clearly showed that machine dehairing damages the surface of Pashmina fibre. From the study, it was concluded that the machine dehairing results in reduction of fibre strength by damaging the surface structure thus it may reduce the life of the final product.Not Availabl