All optical multicasting in wavelength routing mesh networks with power considerations: design and operation

Wavelength routing Wavelength Division Multiplexing (WDM) are optical networks that support all-optical services. They have become the most appealing candidate for wide area backbone networks. Their huge available bandwidth provides the solution for the exponential growth in trayc demands that is due to the increase in the number of users and the surge of more bandwidth intensive network applications and services. A sizable fraction of these applications and services are of multi-point nature. Therefore, supporting multicast service in this network environment is very critical and unique. The all-optical support of various services has advantages, which includes achieving the signal transparency to its content. Nevertheless, the all-optical operational support comes with an associated cost and new issues that make this problem very challenging. In this thesis, we investigate the power-related issues for supporting multicast service in the optical domain, referred to as All-Optical Multicasting (AOM). Our study treats these issues from two networking contexts, namely, Network Provisioning and Connection Provisioning. We propose a number of optimal and heuristic solutions with a unique objective function for each context. In this regard, the objective function for the network provisioning problem is to reduce the network cost, while the solutions for the connection provisioning problem aim to reduce the connection blocking ratio. The optimal formulations are inherently non-linear. However, we introduce novel methods for linearizing them and formulate the problems as Mixed Integer Linear Programs. Also, the design of the heuristic solutions takes into account various optimization factors which results in efficient heuristics that can produce fast solutions that are relatively close to their optimal counterparts, as shown in the numerical results we present

Household Food Insecurity (HFIS): Definitions, Measurements, Socio-Demographic and Economic Aspects

Poverty, food security and malnutrition are major concerns among international health, development and economic organizations. Increasingly, in the last decade, attention has been focused on means of eliminating food insecurity and hunger world-wide (Kennedy, 2002a). For example, the International Congress of Nutrition held in Bangkok, Thailand in 2009 devoted much emphasis on “Nutrition Security For All” (Proceedings:19th International Congress of Nutrition, 2009). Issues on malnutrition in women and children, school-feeding, the World Food Program, and combating hunger worldwide were addressed

Nutritional and Health Outcomes of Household Food Insecurity (HFIS)

Poverty, food security and malnutrition are major concerns among international health, development and economic organizations. Attention has been focused on means of eliminating food insecurity and hunger world-wide. Food security exists when all people, at all times, have physical, social and economic access to sufficient, safe and nutritious food that meets their dietary needs and food preferences for an active and healthy life. Household food security is the application of this concept to the family level, with individuals within households as the focus of concern. (FAO, 2009). The complex nature of food security indicates that in order to achieve a food secure status in a population, a range of aspects need to be assessed. Some examples on these encircle equitable sharing among household members; sufficient household production dedicated towards subsistence; use of soil, water and biodiversity conservation techniques; and the sanitary aspects of cooking. (Bhattacharya et al., 2004). Because of conceptuality, the food insecurity is a multidimensional array of behaviors and perceptions and its potential determinants and consequences are wide-ranging and multidimensional. As a result, the emerging direct qualitative measures of food security offer large potential for use at the international, national and sub-national levels. Furthermore, the increased attention has led to the realization that newer methods for monitoring the prevalence and severity of hunger and food insecurity are needed and that such methods need to be developed in a manner that reflects the perception of food security and hunger by those affected, e.g. the poor (Kennedy, 2002b). Definitions, Measurements, Socio-Demographic and Economic Aspects of Household Food Insecurity (HFIS) had been extensively explained in previous work (Hamad & Ashraf, 2016). In this review, the work focused on the Nutritional and Health Outcomes of Household Food Insecurity (HFIS

Review of Biomass Thermal Gasification

Gasification of biomass is one of the most attractive methods for producing hydrogen rich gas. Syngas production from biomass is an attractive solution for energy crisis. The production of energy from biomass reduces the dependence of developing countries on fossil fuels, as ample biomass is available in the developing countries and is renewable. Downdraft gasifiers are fixed bed gasifiers where the gasifying agent and biomass are flowing downwards, developed for high-volatile fuels such as wood or biomass gasification. Cocurrent flow regime throughout the oxidation and reduction zones reduces the tars and particulates in syngas, which will reduce the necessity of complicated cleaning methods compared to updraft gasifiers especially if the gas is used as a burnable gas in a small community. It is important to ensure homogenous distribution of gasifying agent at the downdraft gasifier throat. This chapter presents latest trends in gasification of biomass using downdraft gasification

Comparison Between the Effects of Different Sources of Dietary Fiber on Blood Lipid Profile in Rats

This study was conducted to investigate the effect of different sources of dietary fiber on serum lipids and lipoproteins in Sprague-Dawley rats, namely total cholesterol (TC), Low-density lipoprotein cholesterol (LDL-C), high–density lipoprotein cholesterol (HDL-C) triglyceride (TG), and (HDL-C/LDL-C) ratio. The experimental diets included casein diet, untreated wheat bran diet, soaked wheat bran diet, Arabic white bread diet, lupine diet, chickpea and pectin diet. Each group of rats (6/group) was fed one of the seven prepared diets for 6 weeks. Untreated wheat bran has hypercholesterolemic effect since it significantly (p<0.05) increased TC, LDL-C and decreased HDL-C values as compared with treated bran diets. The soaking process lowered significantly (p<0.05) TC and LDL-C levels in comparison with casein diet. Chickpea diet had higher significant value of HDL-C than soaked wheat bran and lupine diets. However, it was not significantly different from casein and untreated wheat bran diet.  In addition, Chickpea diet had a significantly higher HDL-C value than pectin diet. The values of HDL-C of the Lupine diet are not significantly different (p>0.05) from casein and pectin diets, but it has also decreased LDL-C. White bread was found to have no hypocholesterolemic effect in comparison with treated brans groups and control group; it raised TG, TC and LDL-C levels. Pectin had a similar behavior in a remarkable decrease blood TC and LDL-C cholesterol. White bread was found to have  no hypocholesterolemic effect in comparison with treated brans groups and control group; it raised TG, TC and LDL-C  levels. It is concluded that the behavior of cereals and legumes varies in its effect on cholesterol–lowering ability. Preparation of wheat bran foods by soaking improve some physiological characteristics of insoluble fibers, particularly lowering total cholesterol TC and low-density lipoprotein cholesterol LDL-C). Keywords: Dietary fiber, Arabic bread, Wheat bran, Soaking, Chickpea, Lupine, Pectin, Lipoproteins, Rat

Management of congenital esophageal stenosis associated with esophageal atresia and its impact on postoperative esophageal stricture

Aim The aim of this work was to study the incidence, management of congenital esophageal stenosis (CES) associated with esophageal atresia (EA) and tracheoesophageal fistula (TEF), and its impact on esophageal stricture (ES) after primary repair.Patients and methods From January 2006 to December 2014, 41 sequential cases of EA with distal TEF were retrospectively studied. Cases with significant ES after primary repair were included in the study. Associated CES was diagnosed in the neonatal period by taking histopathologic samples from the tips of the esophageal pouches, failure to pass a size-6 nasogastric tube distally during primary repair, and by initial esophagogram.Results Significant ES developed in 19 patients (46.3%); of them, six had CES (32%). Three patients had tracheobronchial remnants at the anastomotic site. Two of them had refractory strictures requiring resections and one had mainly major esophageal dysmotility. Patients 4 and 5 had CES distal to the anastomotic site on initial esophagogram. Patient 4 responded well to dilatations, whereas the other one had refractory stricture. Patient 6 had distal CES due to fibromuscular stenosis diagnosed by failure to pass a size-6 nasogastric tube distally. The patient responded well to dilatation, myectomy, and Thal’s fundoplication.Conclusion One-third of the patients with significant stricture had CES; half of them were refractory to dilatation. Failure to have histology specimens and a high index of suspicion will make the incidence of this association a rarity. Diagnosis and management of CES with EA/TEF in the neonatal period is possible. Esophageal dilatation is the initial management for all cases with a low threshold for gastric fundoplication and gastrostomy. Resection is reserved for refractory stenosis.Keywords: congenital esophageal stenosis, esophageal atresia, esophageal stricture, tracheoesophageal fistul

Successful intralesional bleomycin injections for the management of a huge life-threatening cervical lymphangioma in a 3-day-old neonate

Intralesional bleomycin injections (IBI) for the management of a huge life-threatening cervical cystic hygroma is superior to surgery. Surgery has a high rate of morbidity and even mortality. Recurrence and injury to major vessels, nerves, and lymphatics may be unavoidable. The authors report on a 3-day-old male infant who was diagnosed antenatally as a case of a huge cervical cystic hygroma. Postnatally, the patient required mechanical ventilation. The patient was treated successfully with IBI without complications. To our knowledge, this is the youngest case presenting acutely to be treated successfully with IBI without complications.Keywords: bleomycin, neonatal cystic hygroma, respiratory distres

Lignocellulosic Biomasses from Agricultural Wastes Improved the Quality and Physicochemical Properties of Frying Oils

In this work, the effects of using natural lignocellulosic-based adsorbents from sugarcane bagasse (SC), cornstalk piths (CP), and corn cob (CC) on the physicochemical properties and quality of fried oils were studied. The properties of lignocellulosic biomasses were examined using X-ray diffraction (XRD), scanning electron microscope (SEM), and Fourier transform infrared spectroscopy (FTIR). Moreover, the changes in the physicochemical properties of fresh, fried oils (for 4, 8, 12, 16 and 20 h) and adsorbents-treated oils were examined. The XRD results revealed that SC and CP biomasses have more amorphous regions than CC biomass, which had the highest crystallinity percentage. The results also showed that lignocellulosic biomasses enhanced the quality of the used oils. SC was the most effective biomass to enhance the properties of the used sunflower oil. For instance, the acid value of oil samples fried for 20 h reduced from 0.63 ± 0.02 to 0.51 ± 0.02 mg KOH/g oil after SC biomass treatment. For the peroxide value, the SC biomass treatment reduced it from 9.45 ± 0.56 (fried oil for 20 h) to 6.91 ± 0.12 meq O2/kg. Similarly, SC biomass adsorbent reduced the p-Anisidine Value (p-AV) of the used oil (20 h) from 98.45 ± 6.31 to 77.92 ± 3.65. Moreover, SC adsorbents slightly improved the lightness of the used oils (20 h). In conclusion, natural lignocellulosic biomasses, particularly SC, could be utilized as natural adsorbents to improve the oil quality. The results obtained from this study could help in developing sustainable methods to regenerate used oils using natural and cheap adsorbents

A Novel Quinazoline Inhibits Hsp90 Protein, EGFR and Induces Apoptosis in Leukemia Cells

The objective of the first part of this study was to investigate the Hsp90 protein possible activ ity of a novel quinazoline Her2/ EGFR inhibitor (Co mpound No. 1: 4-(2-(4-Oxo-2-thio xo-1,4-d ihydroquinazolin-3(2H)yl)ethyl)benzenesulfonamide) p reviously synthesized by a collaborating group. Heat shock protein 90 (Hsp90) has a central ro le in regulation of several client proteins involved in cancers [1,2]. Several Hsp90 inhibitors of the natural or synthetic origin d isplayed potent anticancer activity [3,4]. Accordingly, Hsp90 emerged as an attractive target in the design of anticancer agents. To evaluate the binding mode of compound No. 1 into the ATPase site of Hsp90, a co mparative mo lecular docking study was performed using AutoDock 4.2. The results of this studywas compared with that of the co-crystallized ligand (ATI-13387X, Onalespib). The energy minimization process of the chemical structures of No. 1 was done following our previous report [5]. The results of the docking study revealed that No. 1 fit n icely into the ATPase site, and it displayed a binding free energy (Gb) of-7.21 kcal/ mo l and inhibition constant (Ki) of 5.19 µM to Hsp90, co mpared to Gb of-7.90 kcal/ mol and Ki of 1.62 µM for ATI-13387X. Furthermore, to confirm this result, the surface plasmon resonance (SPR) was devised to test the Hsp90 inhibition activity of No.1, wh ich was 51 nM co mpared to Rad icico l and 17AA G (1.8 nM, and 360 nM; respectively). Overall, co mpound No. 1 exh ibited pro mising Hsp90 inhib iting activity. The second part of the study focused on the effect of No. 1, Dinaciclib and their co mbinationsin HL-60 leukemia cells. The comb ination showed synergistic EGFR inhib ition effect in HL-60 cells. Moreover, No. 1, Dinaciclib and their combination caused a significant increase in the Sub-G1 co mpared to control and doxorubicin (24h), at the expense of S and G2/M cell cycle phases. Cyclin D3, was consequently inhibited by each of the two drugs, and synergistically by their comb ination in HL-60 cells. Furthermore, each of the two drugs downregulated Survivin, wh ich was synergistically inhib ited by the co mbination. In conclusion, co mpound No.1, Dinaciclib and their comb inations showed synergestic EGFR inhibit ion; and pro-apoptoticeffect in HL-60 cells.This project was funded by the deanship of scientific research, Umm Alqura University, KSA (DSR: 15-M ED-3-1-0060). Keywords: Novel quinazoline EGFR inhi bi tor, Hs p90 protein, Leukemi a cells