Isolates of Candida albicans that differ in virulence for mice elicit strain-specific antibody-mediated protective responses

Three distinct isolates of Candida albicans were used to establish systemic and oral infections in inbred mice that are genetically resistant or susceptible to tissue damage. Patterns of infection differed significantly between both yeasts and mouse strains. Systemic infection conferred significant protection against re-challenge with the homologous, but not the heterologous yeast; however, the protective effect was more evident in the tissue-susceptible CBA/CaH mice than in the resistant BALB/c strain. In contrast, oral infection induced protection against both homologous and heterologous oral challenge, although this was significant only in the CBA/CaH mice. CBA/CaH mice produced antibodies of both IgG1 and IgG2a subclasses, whereas BALB/c mice produced predominantly IgG1. Western blotting demonstrated considerable differences between epitopes recognised by serum antibodies from mice of both strains after immunisation with each of the three yeasts. Thus, different strains of yeast show considerable specificity in antibody responses elicited by either systemic or oral infection. (c) 2005 Elsevier SAS. All rights reserved

Results on the nucleon spin structure

SMC performed an investigation of the spin structure of the nucleon by measuring deep inelastic scattering of polarised muons off polarised protons and deuterons. A summary of the results for spin structure functions and sum rules is given.Comment: 8 pages, LaTeX, Talk given at the Workshop on "Symmetry and Spin - PRAHA98", Prag, September 1998. Proceedings to be published by Czech. Journ. Phy

Traumatic brain injury: future assessment tools and treatment prospects

Traumatic brain injury (TBI) is widespread and leads to death and disability in millions of individuals around the world each year. Overall incidence and prevalence of TBI are likely to increase in absolute terms in the future. Tackling the problem of treating TBI successfully will require improvements in the understanding of normal cerebral anatomy, physiology, and function throughout the lifespan, as well as the pathological and recuperative responses that result from trauma. New treatment approaches and combinations will need to be targeted to the heterogeneous needs of TBI populations. This article explores and evaluates the research evidence in areas that will likely lead to a reduction in TBI-related morbidity and improved outcomes. These include emerging assessment instruments and techniques in areas of structural/chemical and functional neuroimaging and neuropsychology, advances in the realms of cell-based therapies and genetics, promising cognitive rehabilitation techniques including cognitive remediation and the use of electronic technologies including assistive devices and virtual reality, and the emerging field of complementary and alternative medicine

The Origin of Primordial Dwarf Stars and Baryonic Dark Matter

I present a scenario for the production of low mass, degenerate dwarfs of mass $>0.1 M_{\odot}$ via the mechanism of Lenzuni, Chernoff & Salpeter (1992). Such objects meet the mass limit requirements for halo dark matter from microlensing surveys while circumventing the chemical evolution constraints on normal white dwarf stars. I describe methods to observationally constrain this scenario and suggest that such objects may originate in small clusters formed from the thermal instability of shocked, heated gas in dark matter haloes, such as suggested by Fall & Rees (1985) for globular clusters.Comment: TeX, 4 pages plus 2 postscript figures. To appear in Astrophysical Journal Letter

Double logarithms, ln2(1/x)ln^2(1/x), and the NLO DGLAP evolution for the non-singlet component of the nucleon spin structure function, g1g_1

Theoretical predictions show that at low values of Bjorken $x$ the spin structure function, $g_1$ is influenced by large logarithmic corrections, $ln^2(1/x)$, which may be predominant in this region. These corrections are also partially contained in the NLO part of the standard DGLAP evolution. Here we calculate the non-singlet component of the nucleon structure function, $g_1^{NS}=g_1^p-g_1^n$, and its first moment, using a unified evolution equation. This equation incorporates the terms describing the NLO DGLAP evolution and the terms contributing to the $ln^2(1/x)$ resummation. In order to avoid double counting in the overlapping regions of the phase-space, a unique way of including the NLO terms into the unified evolution equation is proposed. The scheme-independent results obtained from this unified evolution are compared to the NLO fit to experimental data, GRSV'2000. Analysis of the first moments of $g_1^{NS}$ shows that the unified evolution including the $ln^2(1/x)$ resummation goes beyond the NLO DGLAP analysis. Corrections generated by double logarithms at low $x$ influence the $Q^2$-dependence of the first moments strongly.Comment: 13 pages, latex, 2 figures; Appendix adde

Popcorn : production and marketing

"K. E. Ziegler, Iowa State University; R. B. Ashman, Purdue University; G. M. White, University of Kentucky; and D. S. Wysong, University of Nebraska ; Reviewers: M. A. Hanna, University of Nebraska Seed Research Committee, Popcorn Institute, IL R. L. Nielsen, Purdue University M. S. Zuber, University of Missouri."--First page.K. E. Ziegler (Iowa State University), R. B. Ashman (Purdue University), G. M. White (University of Kentucky), and D. S. Wysong (University of Nebraska), M. A. Hanna (University of Nebraska Seed Research Committee, Popcorn Institute, IL), R. L. Nielsen (Purdue University), M. S. Zuber (University of Missouri)New 2/85/5

The Globular Cluster System in the Inner Region of M87

1057 globular cluster candidates have been identified in a WFPC2 image of the inner region of M87. The Globular Cluster Luminosity Function (GCLF) can be well fit by a Gaussian profile with a mean value of m_V^0=23.67 +/- 0.07 mag and sigma=1.39 +/- 0.06 mag (compared to m_V^0=23.74 mag and sigma=1.44 mag from an earlier study using the same data by Whitmore it et al. 1995). The GCLF in five radial bins is found to be statistically the same at all points, showing no clear evidence of dynamical destruction processes based on the luminosity function (LF), in contradiction to the claim by Gnedin (1997). Similarly, there is no obvious correlation between the half light radius of the clusters and the galactocentric distance. The core radius of the globular cluster density distribution is R_c=56'', considerably larger than the core of the stellar component (R_c=6.8''). The mean color of the cluster candidates is V-I=1.09 mag which corresponds to an average metallicity of Fe/H = -0.74 dex. The color distribution is bimodal everywhere, with a blue peak at V-I=0.95 mag and a red peak at V-I=1.20 mag. The red population is only 0.1 magnitude bluer than the underlying galaxy, indicating that these clusters formed late in the metal enrichment history of the galaxy and were possibly created in a burst of star/cluster formation 3-6 Gyr after the blue population. We also find that both the red and the blue cluster distributions have a more elliptical shape (Hubble type E3.5) than the nearly spherical galaxy. The average half light radius of the clusters is ~2.5 pc which is comparable to the 3 pc average effective radius of the Milky Way clusters, though the red candidates are ~20% smaller than the blue ones.Comment: 40 pages, 17 figures, 4 tables, latex, accepted for publication in the Ap

Novel Quark Fragmentation Functions and the Nucleon's Transversity Distribution

We define twist-two and twist-three quark fragmentation functions in Quantum Chromodynamics (QCD) and study their physical implications. Using this formalism we show how the nucleon's transversity distribution can be measured in single pion inclusive electroproduction.Comment: 10 pages, uses PHYZZX macro package, 2 PostScript figures (added using FIGURES). MIT-CTP-215