Steroidi i poliketidi iz kore biljke Uvaria hamiltonii

Two known steroids, stigmasterol and 6beta-hydroxystigmasta-4,22-dien-3-one (1) and two unusual polyketides, cis-4-hydroxymellein (2) and trans-4-hydroxymellein (3) were isolated from the stem bark of Uvaria hamiltonii. The structures of the compounds were elucidated independently by high-resolution 2D-NMR techniques and confirmed by comparison with previously reported values.Dva poznata steroida, stigmasterol i 6-hidroksistigmasta-4,22-dien-3-on (1) i dva neuobičajena poliketida, cis-4-hidroksimelein (2) i trans-4-hidroksimelein (3) izolirana su iz kore biljke Uvaria hamiltonii. Strukture spojeva određene su neovisno 2D-NMR spektroskopijom visoke rezolucije i usporedbom s literaturnim podacima

THE EFFECTS OF LOCALISED QUADRICEPS FATIGUE ON BOWLING PERFORMANCE IN FEMALE COUNTY CRICKETERS

Several studies in cricket bowling indicate that a more extended front knee at ball release contributes to increased ball release speed but reported correlation co-efficients vary from 0.34 to 0.52. Portus et al. (2000) found an 8-over spell had no significant effect on knee angle or ball release speed. This study manipulated knee angle by fatiguing the quadriceps to explore its relationship with ball release speed and technique

Singida Regional and District Projections

\ud This report presents population projections for the period 2003 to 2025 for Singida Region and its districts. The projections were made using a Cohort Component Method (Spectrum System), whereby three components responsible for population change, namely: mortality, fertility and\ud migration were projected separately as well as HIV/AIDS prevalence. The projected components were then applied to 2002 midyear base population in order to come up with the desired projections from 2003 to 2025. The report gives mortality, fertility, migration and HIV/AIDS assumptions, and shows Singida’s demographic and socio-economic future trends. The results include estimated population by sex in single years and five-year age groups as well as some demographic indicators. The results show that population growth for the period 2003 to 2025 shows a decrease in growth rates. The projections show that population growth rate will decrease from 2.4 percent in 2003 (with a population of 1,118,874) to 1.5 percent in 2025 (with a population of 1,897,726). Sex Ratio at birth is projected to increase from 95 males per 100 females in 2003 to 100 males per 100 females in 2025. Mortality estimates show that Infant Mortality Rate (IMR) is expected to decline for both sexes from 84 deaths per 1,000 live births in 2003 to 43 deaths per 1,000 live births in 2025. Under Five Mortality Rate (U5MR) for both sexes will also decline from 135 deaths per 1,000 live births in 2003 to 62 deaths per 1,000 live births in the year 2025. The mortality projected estimates further show that the life expectancy at birth for females is higher compared to that of males as expected. Life expectancy at birth for Singida will increase from 55 years in 2003 to 63 years in 2025 for both sexes. For male population, life expectancy at birth will increase from 56 years in year 2003 to 63 years in 2025, while for female population, the life expectancy at birth will increase from 54 years in 2003 to 63 years in 2025. On fertility, TFR will decline from 6.0 children per woman in 2003 to 3.0 children per woman in 2025.\u

Expecting the unexpected: COVID-19 in Kidney Transplant Recipients within United Network for Organ Sharing Region 1

There are numerous case reports and a handful of single center studies reporting on COVID‐19 in kidney transplant recipients. Most reports arise from the epicenters of where the SARS‐CoV‐2 virus was first detected such as New York City and Europe3. We in UNOS Region 1 experienced COVID‐19 weeks to a month later and questioned whether our experience was different. The programs within UNOS Region 1 have had a long history of sharing information in an attempt to mitigate the effect of viruses on our patients

Role of Self Help Groups in Enhancement of Livelihoods of fishermen – A case study of Kakinada Harbour of Andhra Pradesh

Women constitute approximately half of the India's population and play a vital role in building our Nation. Women play a crucial role in Marine fisheries and aquaculture, specifically in the small-scale and artisanal fisheries sector. It is estimated that there are about 5.4 million people fully engaged in fisheries activities, out of which, 3.90 million are fishermen and 1.50 million are fisherwomen. The livelihoods of fishermen are often marked by economic uncertainty, vulnerability to natural factors, and exploitation by middlemen. However, concerted efforts have been made to enhance their living conditions and promote sustainable fishing practices. The primary data is collected from sample of 200 Self Help Groups fisherwomen in the Kakinada harbour of Andhra Pradesh. In the study area 83 per cent are of the sample respondents are living in pucca houses. 47.5 percent of the respondents joined in SHG to avail loan by becoming the member. 50.5 per cent of total respondents belong to 21-40 age group. 33 per cent of the respondents are having primary education, 17.5 per cent are having secondary education and 7 per cent are having higher education. 18 per cent of the sample respondents are spent their SHG loan amount on purchase of home appliances & gold, and 16.5 per cent respondents are spent on children’s education. The perception of the respondents on the impact of SHGs shows that there is a positive correlation between years of membership and impact of SHG in improvement of livelihoods of fishermen

Algae-Derived Marine Oligosaccharides and Their Biological Applications

The biological relevance of algae-derived marine oligosaccharides has potential significance in numerous applications of industrial biotechnology. Marine oligosaccharides are produced in algae naturally and/or by hydrolysis of derived polysaccharides. The potential of marine oligosaccharides is still unexplored, and these molecules, including their derivatives, are a versatile source of chemical diversity. In-depth knowledge on such molecules will provide novel insights, thus depicting their role in discovering mechanisms and the molecular functions within specific biological applications

Anatomical study on sciatic nerve variations in Andhra Pradesh, India

Background: The sciatic nerve is the largest and widest nerve in the body and is derived from ventral rami of spinal nerves L2 to S3. Sciatic nerve appears in the Gluteal region below Piriformis from Pelvic cavity by passing through Greater Sciatic foramen. In between the Ischial tuberosity and greater trochanter of Femur, it reaches the back of the thigh. At the superior angle of Popliteal fossa, it divides into Tibial and common Peroneal (fibular) nerves. The division varies, and it may occur within the pelvis, Gluteal, upper, mid and lower part of thigh. The anatomical variations of the level at which the Sciatic nerve divides is considered important by Neurosurgeons, Anaesthetists, Orthopaedicians and Surgeons.Methods: This study was conducted on 52 lower limbs to determine the level of sciatic nerve bifurcation and its variations on 26 embalmed human cadavers. The data was analyzed manually using numbers, frequencies and percentages.Results: The findings of this study states that in 2 limbs (3.84%) the nerve divided in the gluteal region; in 4 limbs (7.69%) in the pelvic region; in 10 limbs (19.23%) at the junction between upper and middle thigh. The highest incidence of division occurs in 36 limbs (69.23%) at the superior angle of the popliteal fossa.Conclusions: The findings of this study revealed that the majority of sciatic nerve divisions occur   at the superior angle of popliteal fossa while some divided into other regions such as Pelvis, Gluteal and thigh regions

Steroidi i poliketidi iz kore biljke Uvaria hamiltonii

Two known steroids, stigmasterol and 6beta-hydroxystigmasta-4,22-dien-3-one (1) and two unusual polyketides, cis-4-hydroxymellein (2) and trans-4-hydroxymellein (3) were isolated from the stem bark of Uvaria hamiltonii. The structures of the compounds were elucidated independently by high-resolution 2D-NMR techniques and confirmed by comparison with previously reported values.Dva poznata steroida, stigmasterol i 6-hidroksistigmasta-4,22-dien-3-on (1) i dva neuobičajena poliketida, cis-4-hidroksimelein (2) i trans-4-hidroksimelein (3) izolirana su iz kore biljke Uvaria hamiltonii. Strukture spojeva određene su neovisno 2D-NMR spektroskopijom visoke rezolucije i usporedbom s literaturnim podacima

A Post-weaning Obesogenic Diet Exacerbates The Detrimental Effects Of Maternal Obesity On Offspring Insulin Signaling In Adipose Tissue

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Previous studies have shown that maternal diet-induced obesity leads to increased risk of type 2 diabetes in offspring. The current study investigated if weaning onto an obesogenic diet exaggerated the detrimental effects of maternal diet-induced obesity in adipose tissue. Maternal obesity and offspring obesity led to reduced expression of key insulin signalling proteins, including insulin receptor substrate-1 (IRS-1). The effects of maternal obesity and offspring obesity were, generally, independent and additive. Irs1 mRNA levels were similar between all four groups of offspring, suggesting that in both cases post-transcriptional regulation was involved. Maternal diet-induced obesity increased miR-126 expression however levels of this miR were not influenced by a post-weaning obesogenic diet. In contrast, a post-weaning obesogenic diet was associated with increased levels of suppressor of cytokine signaling-1, implicating increased degradation of IRS-1 as an underlying mechanism. Our results suggest that whilst programmed reductions in IRS-1 are associated with increased levels of miR-126 and consequently reduced translation of Irs1 mRNA, the effects of a post-weaning obesogenic diet on IRS-1 are mediated by miR-126 independent mechanisms, including increased IRS-1 protein degradation. These divergent mechanisms explain why the combination of maternal obesity and offspring obesity leads to the most pronounced effects on offspring metabolism.7Medical Research Council [MC_UU_12012/4]Biotechnology and Biological Sciences Research Council [BB/M001636/1]British Heart Foundation [PG/14/20/30769]Sao Paulo Research Foundation [2014/17012-4, 2014/20380-5]Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP

POTENTIAL ANTIMICROBIAL, ANTHELMINTIC AND ANTIOXIDANT ACTIVITIES OF MYRISTICA DACTYLOIDES GAETRN BARK

Objective: The present study was undertaken to determine the antimicrobial, anthelmintic and antioxidant activities of bark extracts of Myristica dactyloides Gaetrn.Methods: The antimicrobial activity of the petroleum ether, ethyl acetate and methanol extracts were evaluated by the Agar well diffusion method against different gram-positive, gram-negative bacteria and fungi. Different extracts of the plant were taken for anthelmintic activity against Indian earthworm Pheretima Posthuma. DPPH radical scavenging activity was measured by the DPPH antioxidant assay method using ascorbic acid as standard and the total phenolic content was estimated spectrophotometrically using Folin-Ciocalteu method.Results: Petroleum ether extract exhibited significant antifungal activity, anthelmintic activity and considerable DPPH radical scavenging activity with an IC50 value of 10.97±0.07µg/ml. Whereas methanol extract exhibited significant antibacterial activity against both gram positive and gram negative bacteria and it is the richest source of phenolics with a total phenolic content of 95.11±2.14 mg of Catechol equivalents/100 mg dried extract. Preliminary phytochemical screening revealed the presence of alkaloids, flavonoids, tannins/phenolics, steroids/triterpenoids and saponins which may be the reason for its biological properties.Conclusion: The findings of this study indicate that this plant is medicinal with prominent antioxidant, antimicrobial and anthelmintic property. The plant can be considered as promising plant species with high potential value for drug preparation.Â