Surgical management of penetrating pulmonary injuries

Chest injuries were reported as early as 3000 BC in the Edwin Smith Surgical Papyrus. Ancient Greek chronicles reveal that they had anatomic knowledge of the thoracic structures. Even in the ancient world, most of the therapeutic modalities for chest wounds and traumatic pulmonary injuries were developed during wartime

Biosurgicals and Trauma

Hemorrhage plays a prominent role in the outcome of trauma patients, from initial injury, through resuscitation, and stabilization. Biosurgicals have recently drawn attention to both the control of bleeding and chronic wound management. However, their role will be examined here in the context of adjuncts to control preoperative, intraoperative, and postoperative bleeding in trauma. A review of the scientific literature relevant to the use of passive and active topical hemostatic devices, as well as systemic pharmacologic agents, for control of hemorrhage is provided, in both military and civilian contexts. Bibliometric publication patterns and published guidelines are examined to identify the range of individual products available and the degree of attention they receive in the management of acute traumatic injuries. It is imperative that the evidentiary basis for the use of these agents be weighed against their cost and potential risks

Quantifying visible land degradation of saline wetlands in an arid region of NE Spain

5 Pags.- 3 Figs. Paper # 4_18 in: Á. Faz, R. Ortiz, G. García (Eds.) 2004. Extended abstracts in CDRom. 4th Internat. Conference on Land Degradation. 12-17 September, Cartagena, Spain. ISBN: 84-95781-40-9.This Paper aims to study the present status of the saladas and to quantify their visible degradation with the help of a Geographical Information System (GIS). For this purpose we analyze the changes that have occurred in the last decades and we establish indices to evaluate the condition of the saladas in terms of conservation status and vulnerability.Peer reviewe

Enhanced fracture strength in the working layer of rolls manufactured in Ni-hard cast iron alloyed with Mo, Nb and Mg

One of the main in-service failure mechanisms of the work-rolls used in hot strip mill finishing stands is surface spalling. The indefinite chill double-poured rolls usually comprise of a peripheral working layer made of crushed Ni-hard cast iron and a grey cast iron core, mostly pearlitic matrix with spheroidal graphite. To enhance its wear resistance, the working layer can be alloyed with Mo and Nb. The possible cracking and spalling of the surfaces of these work-rolls is strongly influenced by the presence of carbides and the continuity of their network. The flexural and impact toughness tests are reliable testing methods to assess these properties. The aim of this paper is to identify those manufacturing factors that have a significant effect on the flexural strength and toughness of this material, correlating the results with the volume fraction of precipitated carbides. It is worth highlighting, among the analysed factors are the liquidus temperature, the %Si, the use of an inoculant with traces of Lanthanum, and inoculation with different amounts of FeB, SiCa and Mg. Inoculation with SiCa is found to have a positive effect on the toughness of the material, breaking up the continuity of the carbide network, while FeB is found to act as a heterogeneous nucleant for NbC precipitation. However, high FeB contents reduce flexural strength and do not have a significant effect on the hardness of the material. To enhance the fracture toughness of the working layer, a liquidus temperature in the 1270–1275 °C range is recommended, as well as inoculating the ladle with Mg, 3 kg/T FeB and 0.6 kg/T SiCa

Artificial intelligence approaches for the generation and assessment of believable human-like behaviour in virtual characters

Having artificial agents to autonomously produce human-like behaviour is one of the most ambitious original goals of Artificial Intelligence (AI) and remains an open problem nowadays. The imitation game originally proposed by Turing constitute a very effective method to prove the indistinguishability of an artificial agent. The behaviour of an agent is said to be indistinguishable from that of a human when observers (the so-called judges in the Turing test) can not tell apart humans and non-human agents. Different environments, testing protocols, scopes and problem domains can be established to develop limited versions or variants of the original Turing test. In this paper we use a specific version of the Turing test, based on the international BotPrize competition, built in a First-Person Shooter video game, where both human players and non-player characters interact in complex virtual environments. Based on our past experience both in the BotPrize competition and other robotics and computer game AI applications we have developed three new more advanced controllers for believable agents: two based on a combination of the CERA-CRANIUM and SOAR cognitive architectures and other based on ADANN, a system for the automatic evolution and adaptation of artificial neural networks. These two new agents have been put to the test jointly with CCBot3, the winner of BotPrize 2010 competition [1], and have showed a significant improvement in the humanness ratio. Additionally, we have confronted all these bots to both First-person believability assessment (BotPrize original judging protocol) and Third-person believability assess- ment, demonstrating that the active involvement of the judge has a great impact in the recognition of human-like behaviour.MICINN -Ministerio de Ciencia e Innovación(FCT-13-7848

Collaborative Learning Models on Distance Scenarios with Learning Design: A Case Study

6 págs, 1 fig.-- Publicado en la Sección: "Artículos seleccionados de IEEE ICALT" (ICALT'2008 - Eighth IEEE International Conference on Advanced Learning Technologies, Santander, Cantabria, Spain, Jul 1-5, 2008).Previamente publicado como ponencia (en inglés) en: Proceedings ICALT'08 - Eighth IEEE International Conference on Advanced Learning Technologies, 2008, p. 278-282, http://e-archivo.uc3m.es/handle/10016/8964Collaborative learning models are widely used in educational institutions. These models require a high interaction level among students and are mainly oriented towards in-class scenarios. But when collaborative models are deployed in a distant scenario, user expressiveness is significantly reduced thus creating a gap that hinders the effectiveness of this collaboration. A computer-supported model provides a set of tools to compensate for the distant scenario and reduce this gap. This paper presents the issues and solutions derived from the design and deployment of a complex collaborative model in a distant scenario. The course structure was captured using the Learning Design specification, and an architecture based on Virtual Network Computing was used to provide the required collaborative tools. The course was included as part of a regular undergraduate program in three higher educational institutions.Trabajo parcialmente financiado por el Programa Nacional de Tecnologías de la Información y de las Comunicaciones, Proyectos MOSAIC (TSI2005-08225-C07-02/04) y LEARN3 (TIN2008-05163/TSI).Publicad

InstanceCollage: a tool for the particularization of collaborative IMS-LD scripts

Current research work in e-learning and more specifically in the field of CSCL (Computer Supported Collaborative Learning) deals with design of collaborative activities, according to computer-interpretable specifications, such as IMS Learning Design, and their posterior enactment using LMSs (Learning Management Systems). A script that describes such collaborative activities is typically designed beforehand in order to structure collaboration, and defines the features that determine the behavior of the LMS, for instance, the sequence of activities or the groups/role distribution. In CSCL settings, group management and composition are especially relevant and affect the chances of achieving the expected learning outcomes. This paper presents a software tool, named InstanceCollage, which aims at facilitating the configuration and population of groups for IMS-LD scripts created with the authoring tool Collage, and discusses the implications of the IMS-LD specification with respect to this task. InstanceCollage is designed to process collaboration scripts based on CLFPs (Collaborative Learning Flow Patterns). Using this type of patterns, InstanceCollage focuses on the importance of understanding the function of groups within the learning strategy of the script. This paper describes the approach taken in InstanceCollage to facilitate this understanding for non-expert users. Additionally, two case studies are presented, which represent complex authentic collaborative learning scenarios, as a proof of concept of the functionality of this tool. The case studies are also used to illustrate the requirements of group configuration tools and to show that InstanceCollage complies to such requirements

Molecular survey of CRL618

We present the complete data set, model and line identification of a survey of the emission from the C-rich protoplanetary nebula CRL 618 performed with the IRAM-30m telescope in the following frequency ranges: 80.25-115.75 GHz, 131.25-179.25 GHz, and 204.25-275.250 GHz. A selection of lines from different species has been used in previous works to derive the structure of the source, its physical conditions and the chemical abundances in the different gas regions. In this work, we have used this information to run a global simulation of the spectrum in order to check the consistency of the model and to ease the task of line identification. The total number of lines that have a correspondence in both data and model is ~3100, although quite often in this object many lines blend into complex features so that the model, that takes into account line blending, is a key tool at this stage of the analysis. Of all the lines that we have been able to label, ~55% of them belong to the different forms of HC3N, and ~18% to those of HC5N. The density of remaining unidentified features above the 3sigma limit is only one per ~2.1 GHz (74 features), which is unprecedented in the analysis of this type of large millimeter-wave line surveys.Comment: Accepted in ApJ (November 2006). Figures bitmapped to lower resolution. The complete set of tables and figures will be published only electronically (ApJ online

A glucotolerant β-glucosidase from the fungus Talaromyces amestolkiae and its conversion into a glycosynthase for glycosylation of phenolic compounds

The interest for finding novel β-glucosidases that can improve the yields to produce second-generation (2G) biofuels is still very high. One of the most desired features for these enzymes is glucose tolerance, which enables their optimal activity under high-glucose concentrations. Besides, there is an additional focus of attention on finding novel enzymatic alternatives for glycoside synthesis, for which a mutated version of glycosidases, named glycosynthases, has gained much interest in recent years. Results In this work, a glucotolerant β-glucosidase (BGL-1) from the ascomycete fungus Talaromyces amestolkiae has been heterologously expressed in Pichia pastoris, purified, and characterized. The enzyme showed good efficiency on p-nitrophenyl glucopyranoside (pNPG) (Km= 3.36 ± 0.7 mM, kcat= 898.31 s−1), but its activity on cellooligosaccharides, the natural substrates of these enzymes, was much lower, which could limit its exploitation in lignocellulose degradation applications. Interestingly, when examining the substrate specificity of BGL-1, it showed to be more active on sophorose, the β-1,2 disaccharide of glucose, than on cellobiose. Besides, the transglycosylation profile of BGL-1 was examined, and, for expanding its synthetic capacities, it was converted into a glycosynthase. The mutant enzyme, named BGL-1-E521G, was able to use α-d-glucosyl-fluoride as donor in glycosylation reactions, and synthesized glucosylated derivatives of different pNP-sugars in a regioselective manner, as well as of some phenolic compounds of industrial interest, such as epigallocatechin gallate (EGCG). Conclusions In this work, we report the characterization of a novel glucotolerant 1,2-β-glucosidase, which also has a considerable activity on 1,4-β-glucosyl bonds, that has been cloned in P. pastoris, produced, purified and characterized. In addition, the enzyme was converted into an efficient glycosynthase, able to transfer glucose molecules to a diversity of acceptors for obtaining compounds of interest. The remarkable capacities of BGL-1 and its glycosynthase mutant, both in hydrolysis and synthesis, suggest that it could be an interesting tool for biotechnological applications

Extremity tourniquet training at high seas

Background Future navy officers require unique training for emergency medical response in the isolated maritime environment. The authors issued a workshop on extremity bleeding control, using four different commercial extremity tourniquets onboard a training sail ship. The purposes were to assess participants' perceptions of this educational experience and evaluate self-application simplicity while navigating on high seas. Methods A descriptive observational study was conducted as part of a workshop issued to volunteer training officers. A post-workshop survey collected their perceptions about the workshops' content usefulness and adequacy, tourniquet safety, self-application simplicity, and device preference. Tourniquet preference was measured by frequency count while the rest of the studied variables on a one-to-ten Likert scale. Frequencies and percentages were calculated for the studied variables, and application simplicity means compared using the ANOVA test (p < 0.05). Results Fifty-one Spanish training naval officers, aged 20 or 21, perceived high sea workshop content’s usefulness, adequacy, and safety level at 8.6/10, 8.7/10, and 7.5/10, respectively. As for application simplicity, CAT and SAM-XT were rated equally with a mean of 8.5, followed by SWAT (7.9) and RATS (6.9), this one statistically different from the rest (p < 0.01). Windlass types were preferred by 94%. Conclusions The training sail ship’s extremity bleeding control workshop was perceived as useful and its content adequate by the participating midshipmen. Windlass types were regarded as easier to apply than elastic counterparts. They were also preferred by nine out of every ten participants