CuPc Adsorption on Au(110)-(1 × 2): From a Monomer to a Periodic Chain

Using scanning tunneling microscopy (STM), we study the adsorption of copper-phthalocyanine (CuPc) on the anisotropic Au(110)-(1 × 2) surface as a function of coverage. For the initial adsorption at room temperature, we observe CuPc monomers as well as a molecular chain that forms along the step edge. By STM manipulation, we reveal that the CuPc adsorption is accompanied by surface reconstruction from the initial adsorption stage; the periodicity beneath the monomer and the chain changes locally from (1 × 2) to (1 × 1) and (1 × 3), respectively. This finding highlights that the Au atom mobility of the surface plays an essential role in CuPc adsorption. At higher coverage, we observe the development of CuPc chains along the [110] direction on the terrace with periodicities of (7 × 5) and (5 × 5), and compare the obtained results with those from the previous studies by diffraction methods

Expression of ZIC family genes in meningiomas and other brain tumors

<p>Abstract</p> <p>Background</p> <p>Zic zinc finger proteins are present in the developing rodent meninges and are required for cell proliferation and differentiation of meningeal progenitors. Although human <it>ZIC </it>genes are known to be molecular markers for medulloblastomas, their expression in meningioma has not been addressed to date.</p> <p>Methods</p> <p>We examined the mRNA and protein expression of human <it>ZIC1</it>, <it>ZIC2</it>, <it>ZIC3</it>, <it>ZIC4 </it>and <it>ZIC5 </it>genes in meningiomas in comparison to other brain tumors, using RT-PCR, analysis of published microarray data, and immunostaining.</p> <p>Results</p> <p><it>ZIC1</it>, <it>ZIC2 </it>and <it>ZIC5 </it>transcript levels in meningiomas were higher than those in whole brain or normal dura mater, whereas all five <it>ZIC </it>genes were abundantly expressed in medulloblastomas. The expression level of <it>ZIC1 </it>in public microarray data was greater in meningiomas classified as World Health Organization Grade II (atypical) than those classified as Grade I (benign). Immunoscreening using anti-ZIC antibodies revealed that 23 out of 23 meningioma cases were ZIC1/2/3/5-immunopositive. By comparison, nuclear staining by the anti-ZIC4 antibody was not observed in any meningioma case, but was strongly detected in all four medulloblastomas. ZIC-positive meningiomas included meningothelial, fibrous, transitional, and psammomatous histological subtypes. In normal meninges, ZIC-like immunoreactivities were detected in vimentin-expressing arachnoid cells both in human and mouse.</p> <p>Conclusions</p> <p>ZIC1, ZIC2, and ZIC5 are novel molecular markers for meningiomas whereas <it>ZIC4 </it>expression is highly selective for medulloblastomas. The pattern of <it>ZIC </it>expression in both of these tumor types may reflect the properties of the tissues from which the tumors are derived.</p

Magnetic phase diagram of the diluted metamagnet Fe\u3csub\u3e0.95\u3c/sub\u3eMg\u3csub\u3e0.05\u3c/sub\u3eBr\u3csub\u3e2\u3c/sub\u3e

The axial magnetic phase diagram of the antiferromagnet Fe0.95Mg0.05Br2 is studied by specific heat, superconducting quantum interference device, and Faraday rotation techniques. The diamagnetic impurities give rise to random-field criticality along the second-order phase line Hc(T) between TN=13.1 K and a multicritical point at Tm≈5 K, and to a spin-flop line between Tm and the critical end-point temperature Te≈3.5 K. The phase line H1(T)c(T) ending at Tm is probably due to symmetric nondiagonal exchange

Frustrated minority spins in GeNi2O4

Recently, two consecutive phase transitions were observed, upon cooling, in an antiferromagnetic spinel GeNi$_2$O$_4$ at $T_{N1}=12.1$ K and $T_{N2}=11.4$ K, respectively \cite{matsuno, crawford}. Using unpolarized and polarized elastic neutron scattering we show that the two transitions are due to the existence of frustrated minority spins in this compound. Upon cooling, at $T_{N1}$ the spins on the \kagome planes order ferromagnetically in the plane and antiferromagnetically between the planes (phase I), leaving the spins on the triangular planes that separate the \kagome planes frustrated and disordered. At the lower $T_{N2}$, the triangular spins also order in the $$ plane (phase II). We also present a scenario involving exchange interactions that qualitatively explains the origin of the two purely magnetic phase transitions

Memory and chaos in an Ising spin glass

The non-equilibrium dynamics of the model 3d-Ising spin glass - Fe$_{0.55}$Mn$_{0.45}$TiO$_3$ - has been investigated from the temperature and time dependence of the zero field cooled magnetization recorded under certain thermal protocols. The results manifest chaos, rejuvenation and memory features of the equilibrating spin configuration that are very similar to those observed in corresponding studies of the archetypal RKKY spin glass Ag(Mn). The sample is rapidly cooled in zero magnetic field, and the magnetization recorded on re-heating. When a stop at constant temperature $T_s$ is made during the cooling, the system evolves toward its equilibrium state at this temperature. The equilibrated state established during the stop becomes frozen in on further cooling and is retrieved on re-heating. The memory of the aging at $T_s$ is not affected by a second stop at a lower temperature $T'_s$. Reciprocally, the first equilibration at $T_s$ has no influence on the relaxation at $T'_s$, as expected within the droplet model for domain growth in a chaotic landscape.Comment: REVTeX style; 4 pages, 4 figure

Zic2 hypomorphic mutant mice as a schizophrenia model and ZIC2 mutations identified in schizophrenia patients

ZIC2 is a causal gene for holoprosencephaly and encodes a zinc-finger-type transcriptional regulator. We characterized Zic2kd/+ mice with a moderate (40%) reduction in Zic2 expression. Zic2kd/+ mice showed increased locomotor activity in novel environments, cognitive and sensorimotor gating dysfunctions, and social behavioral abnormalities. Zic2kd/+ brain involved enlargement of the lateral ventricle, thinning of the cerebral cortex and corpus callosum, and decreased number of cholinergic neurons in the basal forebrain. Because these features are reminiscent of schizophrenia, we examined ZIC2 variant-carrying allele frequencies in schizophrenia patients and in controls in the Japanese population. Among three novel missense mutations in ZIC2, R409P was only found in schizophrenia patients, and was located in a strongly conserved position of the zinc finger domain. Mouse Zic2 with the corresponding mutation showed lowered transcription-activating capacity and had impaired target DNA-binding and co-factor-binding capacities. These results warrant further study of ZIC2 in the pathogenesis of schizophrenia