Predicting future left anterior descending artery events from non-culprit lesions:insights from the Lipid-Rich Plaque study

AIMS: The left anterior descending (LAD) artery is the most frequently affected site by coronary artery disease. The prospective Lipid Rich Plaque (LRP) study, which enrolled patients undergoing imaging of non-culprits followed over 2 years, reported the successful identification of coronary segments at risk of future events based on near-infrared spectroscopy-intravascular ultrasound (NIRS-IVUS) lipid signals. We aimed to characterize the plaque events involving the LAD vs. non-LAD segments. METHODS AND RESULTS: LRP enrolled 1563 patients from 2014 to 2016. All adjudicated plaque events defined by the composite of cardiac death, cardiac arrest, non-fatal myocardial infarction, acute coronary syndrome, revascularization by coronary bypass or percutaneous coronary intervention, and rehospitalization for angina with >20% stenosis progression and reported as non-culprit lesion-related major adverse cardiac events (NC-MACE) were classified by NIRS-IVUS maxLCBI4 mm (maximum 4-mm Lipid Core Burden Index) ≤400 or >400 and association with high-risk-plaque characteristics, plaque burden ≥70%, and minimum lumen area (MLA) ≤4 mm2. Fifty-seven events were recorded with more lipid-rich plaques in the LAD vs. left circumflex and right coronary artery; 12.5% vs. 10.4% vs. 11.3%, P = 0.097. Unequivocally, a maxLCBI4 mm >400 in the LAD was more predictive of NC-MACE [hazard ratio (HR) 4.32, 95% confidence interval (CI) (1.93-9.69); P = 0.0004] vs. [HR 2.56, 95% CI (1.06-6.17); P = 0.0354] in non-LAD segments. MLA ≤4 mm2 within the maxLCBI4 mm was significantly higher in the LAD (34.1% vs. 25.9% vs. 13.7%, P < 0.001). CONCLUSION: Non-culprit lipid-rich segments in the LAD were more frequently associated with plaque-level events. LAD NIRS-IVUS screening may help identify patients requiring intensive surveillance and medical treatment

On-Orbit Performance of the Far Ultraviolet Spectroscopic Explorer (FUSE) Satellite

Launch of the Far Ultraviolet Spectroscopic Explorer (FUSE) has been followed by an extensive period of calibration and characterization as part of the preparation for normal satellite operations. Major tasks carried out during this period include initial coalignment, focusing and characterization of the four instrument channels, and a preliminary measurement of the resolution and throughput performance of the instrument. We describe the results from this test program, and present preliminary estimates of the on-orbit performance of the FUSE satellite based on a combination of this data and prelaunch laboratory measurements.Comment: 8 pages, including 3 figures. This paper will appear in the FUSE special issue of ApJ Letter

Multi-probe analysis of the galaxy cluster CL J1226.9+3332: Hydrostatic mass and hydrostatic-To-lensing bias

The precise estimation of the mass of galaxy clusters is a major issue for cosmology. Large galaxy cluster surveys rely on scaling laws that relate cluster observables to their masses. From the high-resolution observations of ∼45 galaxy clusters with the NIKA2 and XMM-Newton instruments, the NIKA2 Sunyaev-Zela'dovich Large Program should provide an accurate scaling relation between the thermal Sunyaev-Zela'dovich effect and the hydrostatic mass. In this paper we present an exhaustive analysis of the hydrostatic mass of the well-known galaxy cluster CL J1226.9+3332, the highest-redshift cluster in the NIKA2 Sunyaev-Zela'dovich Large Program at z=0.89. We combined the NIKA2 observations with thermal Sunyaev-Zela'dovich data from the NIKA, Bolocam, and MUSTANG instruments and XMM-Newton X-ray observations, and tested the impact of the systematic effects on the mass reconstruction. We conclude that slight differences in the shape of the mass profile can be crucial when defining the integrated mass at R500, which demonstrates the importance of the modelling in the mass determination. We prove the robustness of our hydrostatic mass estimates by showing the agreement with all the results found in the literature. Another key factor for cosmology is the bias of the masses estimated assuming the hydrostatic equilibrium hypothesis. Based on the lensing convergence maps from the Cluster Lensing And Supernova survey with Hubble (CLASH) data, we obtain the lensing mass estimate for CL J1226.9+3332. From this we are able to measure the hydrostatic-To-lensing mass bias for this cluster, which spans from 1-bHSE/lens∼0.7 to 1, presenting the impact of data sets and mass reconstruction models on the bias

Predicting future left anterior descending artery events from non-culprit lesions: insights from the Lipid-Rich Plaque study

AIMS: The left anterior descending (LAD) artery is the most frequently affected site by coronary artery disease. The prospective Lipid Rich Plaque (LRP) study, which enrolled patients undergoing imaging of non-culprits followed over 2 years, reported the successful identification of coronary segments at risk of future events based on near-infrared spectroscopy-intravascular ultrasound (NIRS-IVUS) lipid signals. We aimed to characterize the plaque events involving the LAD vs. non-LAD segments. METHODS AND RESULTS: LRP enrolled 1563 patients from 2014 to 2016. All adjudicated plaque events defined by the composite of cardiac death, cardiac arrest, non-fatal myocardial infarction, acute coronary syndrome, revascularization by coronary bypass or percutaneous coronary intervention, and rehospitalization for angina with >20% stenosis progression and reported as non-culprit lesion-related major adverse cardiac events (NC-MACE) were classified by NIRS-IVUS maxLCBI4 mm (maximum 4-mm Lipid Core Burden Index) ≤400 or >400 and association with high-risk-plaque characteristics, plaque burden ≥70%, and minimum lumen area (MLA) ≤4 mm2. Fifty-seven events were recorded with more lipid-rich plaques in the LAD vs. left circumflex and right coronary artery; 12.5% vs. 10.4% vs. 11.3%, P = 0.097. Unequivocally, a maxLCBI4 mm >400 in the LAD was more predictive of NC-MACE [hazard ratio (HR) 4.32, 95% confidence interval (CI) (1.93-9.69); P = 0.0004] vs. [HR 2.56, 95% CI (1.06-6.17); P = 0.0354] in non-LAD segments. MLA ≤4 mm2 within the maxLCBI4 mm was significantly higher in the LAD (34.1% vs. 25.9% vs. 13.7%, P < 0.001). CONCLUSION: Non-culprit lipid-rich segments in the LAD were more frequently associated with plaque-level events. LAD NIRS-IVUS screening may help identify patients requiring intensive surveillance and medical treatment

Identification of patients and plaques vulnerable to future coronary events with near-infrared spectroscopy intravascular ultrasound imaging: a prospective, cohort study

Background: Near-infrared spectroscopy (NIRS) intravascular ultrasound imaging can detect lipid-rich plaques (LRPs). LRPs are associated with acute coronary syndromes or myocardial infarction, which can result in revascularisation or cardiac death. In this study, we aimed to establish the relationship between LRPs detected by NIRS-intravascular ultrasound imaging at unstented sites and subsequent coronary events from new culprit lesions. Methods: In this prospective, cohort study (LRP), patients from 44 medical centres were enrolled in Italy, Latvia, Netherlands, Slovakia, UK, and the USA. Patients with suspected coronary artery disease who underwent cardiac catheterisation with possible ad hoc percutaneous coronary intervention were eligible to be enrolled. Enrolled patients underwent scanning of non-culprit segments using NIRS-intravascular ultrasound imaging. The study had two hierarchal primary hypotheses, patient and plaque, each testing the association between maximum 4 mm Lipid Core Burden Index (maxLCBI4mm) and non-culprit major adverse cardiovascular events (NC-MACE). Enrolled patients with large LRPs (≥250 maxLCBI4mm) and a randomly selected half of patients with small LRPs (<250 maxLCBI4mm) were followed up for 24 months. This study is registered with ClinicalTrials.gov, NCT02033694. Findings: Between Feb 21, 2014, and March 30, 2016, 1563 patients were enrolled. NIRS-intravascular ultrasound device-related events were seen in six (0·4%) patients. 1271 patients (mean age 64 years, SD 10, 883 [69%] men, 388 [31%]women) with analysable maxLCBI4mm were allocated to follow-up. The 2-year cumulative incidence of NC-MACE was 9% (n=103). Both hierarchical primary hypotheses were met. On a patient level, the unadjusted hazard ratio (HR) for NC-MACE was 1·21 (95% CI 1·09–1·35; p=0·0004) for each 100-unit increase maxLCBI4mm) and adjusted HR 1·18 (1·05–1·32; p=0·0043). In patients with a maxLCBI4mm more than 400, the unadjusted HR for NC-MACE was 2·18 (1·48–3·22; p<0·0001) and adjusted HR was 1·89 (1·26–2·83; p=0·0021). At the plaque level, the unadjusted HR was 1·45 (1·30–1·60; p<0·0001) for each 100-unit increase in maxLCBI4mm. For segments with a maxLCBI4mm more than 400, the unadjusted HR for NC-MACE was 4·22 (2·39–7·45; p<0·0001) and adjusted HR was 3·39 (1·85–6·20; p<0·0001). Interpretation: NIRS imaging of non-obstructive territories in patients undergoing cardiac catheterisation and possible percutaneous coronary intervention was safe and can aid in identifying patients and segments at higher risk for subsequent NC-MACE. NIRS-intravascular ultrasound imaging adds to the armamentarium as the first diagnostic tool able to detect vulnerable patients and plaques in clinical practice. Funding: Infraredx

The XXL Survey LV. Pressure profile and YSZY_{\rm SZ}-MM scaling relation in three low-mass galaxy clusters at z∼1z\sim1 observed with NIKA2

International audienceThe thermodynamical properties of the intracluster medium (ICM) are driven by scale-free gravitational collapse, but they also reflect the rich astrophysical processes at play in galaxy clusters. At low masses ($\sim 10^{14}$ M$_{\odot}$) and high redshift ($z \gtrsim 1$), these properties remain poorly constrained observationally, due to the difficulty in obtaining resolved and sensitive data. This paper aims at investigating the inner structure of the ICM as seen through the Sunyaev-Zel'dovich (SZ) effect in this regime of mass and redshift. Focus is set on the thermal pressure profile and the scaling relation between SZ flux and mass, namely the $Y_{\rm SZ} - M$ scaling relation. The three galaxy clusters XLSSC~072 ($z=1.002$), XLSSC~100 ($z=0.915$), and XLSSC~102 ($z=0.969$), with $M_{500} \sim 2 \times 10^{14}$ M$_{\odot}$, were selected from the XXL X-ray survey and observed with the NIKA2 millimeter camera to image their SZ signal. XMM-Newton X-ray data were used in complement to the NIKA2 data to derive masses based on the $Y_X - M$ relation and the hydrostatic equilibrium. The SZ images of the three clusters, along with the X-ray and optical data, indicate dynamical activity related to merging events. The pressure profile is consistent with that expected for morphologically disturbed systems, with a relatively flat core and a shallow outer slope. Despite significant disturbances in the ICM, the three high-redshift low-mass clusters follow remarkably well the $Y_{\rm SZ}-M$ relation expected from standard evolution. These results indicate that the dominant physics that drives cluster evolution is already in place by $z \sim 1$, at least for systems with masses above $M_{500} \sim 10^{14}$ M$_{\odot}$

The XXL Survey LV. Pressure profile and YSZY_{\rm SZ}-MM scaling relation in three low-mass galaxy clusters at z∼1z\sim1 observed with NIKA2

International audienceThe thermodynamical properties of the intracluster medium (ICM) are driven by scale-free gravitational collapse, but they also reflect the rich astrophysical processes at play in galaxy clusters. At low masses ($\sim 10^{14}$ M$_{\odot}$) and high redshift ($z \gtrsim 1$), these properties remain poorly constrained observationally, due to the difficulty in obtaining resolved and sensitive data. This paper aims at investigating the inner structure of the ICM as seen through the Sunyaev-Zel'dovich (SZ) effect in this regime of mass and redshift. Focus is set on the thermal pressure profile and the scaling relation between SZ flux and mass, namely the $Y_{\rm SZ} - M$ scaling relation. The three galaxy clusters XLSSC~072 ($z=1.002$), XLSSC~100 ($z=0.915$), and XLSSC~102 ($z=0.969$), with $M_{500} \sim 2 \times 10^{14}$ M$_{\odot}$, were selected from the XXL X-ray survey and observed with the NIKA2 millimeter camera to image their SZ signal. XMM-Newton X-ray data were used in complement to the NIKA2 data to derive masses based on the $Y_X - M$ relation and the hydrostatic equilibrium. The SZ images of the three clusters, along with the X-ray and optical data, indicate dynamical activity related to merging events. The pressure profile is consistent with that expected for morphologically disturbed systems, with a relatively flat core and a shallow outer slope. Despite significant disturbances in the ICM, the three high-redshift low-mass clusters follow remarkably well the $Y_{\rm SZ}-M$ relation expected from standard evolution. These results indicate that the dominant physics that drives cluster evolution is already in place by $z \sim 1$, at least for systems with masses above $M_{500} \sim 10^{14}$ M$_{\odot}$

The XXL Survey LV. Pressure profile and YSZY_{\rm SZ}-MM scaling relation in three low-mass galaxy clusters at z∼1z\sim1 observed with NIKA2

International audienceThe thermodynamical properties of the intracluster medium (ICM) are driven by scale-free gravitational collapse, but they also reflect the rich astrophysical processes at play in galaxy clusters. At low masses ($\sim 10^{14}$ M$_{\odot}$) and high redshift ($z \gtrsim 1$), these properties remain poorly constrained observationally, due to the difficulty in obtaining resolved and sensitive data. This paper aims at investigating the inner structure of the ICM as seen through the Sunyaev-Zel'dovich (SZ) effect in this regime of mass and redshift. Focus is set on the thermal pressure profile and the scaling relation between SZ flux and mass, namely the $Y_{\rm SZ} - M$ scaling relation. The three galaxy clusters XLSSC~072 ($z=1.002$), XLSSC~100 ($z=0.915$), and XLSSC~102 ($z=0.969$), with $M_{500} \sim 2 \times 10^{14}$ M$_{\odot}$, were selected from the XXL X-ray survey and observed with the NIKA2 millimeter camera to image their SZ signal. XMM-Newton X-ray data were used in complement to the NIKA2 data to derive masses based on the $Y_X - M$ relation and the hydrostatic equilibrium. The SZ images of the three clusters, along with the X-ray and optical data, indicate dynamical activity related to merging events. The pressure profile is consistent with that expected for morphologically disturbed systems, with a relatively flat core and a shallow outer slope. Despite significant disturbances in the ICM, the three high-redshift low-mass clusters follow remarkably well the $Y_{\rm SZ}-M$ relation expected from standard evolution. These results indicate that the dominant physics that drives cluster evolution is already in place by $z \sim 1$, at least for systems with masses above $M_{500} \sim 10^{14}$ M$_{\odot}$

The XXL Survey LV. Pressure profile and YSZY_{\rm SZ}-MM scaling relation in three low-mass galaxy clusters at z∼1z\sim1 observed with NIKA2

International audienceThe thermodynamical properties of the intracluster medium (ICM) are driven by scale-free gravitational collapse, but they also reflect the rich astrophysical processes at play in galaxy clusters. At low masses ($\sim 10^{14}$ M$_{\odot}$) and high redshift ($z \gtrsim 1$), these properties remain poorly constrained observationally, due to the difficulty in obtaining resolved and sensitive data. This paper aims at investigating the inner structure of the ICM as seen through the Sunyaev-Zel'dovich (SZ) effect in this regime of mass and redshift. Focus is set on the thermal pressure profile and the scaling relation between SZ flux and mass, namely the $Y_{\rm SZ} - M$ scaling relation. The three galaxy clusters XLSSC~072 ($z=1.002$), XLSSC~100 ($z=0.915$), and XLSSC~102 ($z=0.969$), with $M_{500} \sim 2 \times 10^{14}$ M$_{\odot}$, were selected from the XXL X-ray survey and observed with the NIKA2 millimeter camera to image their SZ signal. XMM-Newton X-ray data were used in complement to the NIKA2 data to derive masses based on the $Y_X - M$ relation and the hydrostatic equilibrium. The SZ images of the three clusters, along with the X-ray and optical data, indicate dynamical activity related to merging events. The pressure profile is consistent with that expected for morphologically disturbed systems, with a relatively flat core and a shallow outer slope. Despite significant disturbances in the ICM, the three high-redshift low-mass clusters follow remarkably well the $Y_{\rm SZ}-M$ relation expected from standard evolution. These results indicate that the dominant physics that drives cluster evolution is already in place by $z \sim 1$, at least for systems with masses above $M_{500} \sim 10^{14}$ M$_{\odot}$