HUBUNGAN PERILAKU MEROKOK DENGAN SUBJECTIVE WELL-BEING PADA MAHASISWA FAKULTAS KEDOKTERAN DALAM MENGHADAPI PEMBELAJARAN TATAP MUKA DI BANDAR LAMPUNG

Subjective well-being sangat penting dimiliki oleh mahasiswa, terutama mahasiswa fakultas kedokteran. Faktor yang mempengaruhi subjective well-being pada mahasiswa fakultas kedokteran adalah kesehatan dan gaya hidup. perilaku merokok merupakan salah satu gaya hidup yang dipercaya dapat menghilangkan stres pada mahasiswa terutama mahasiswa kedokteran.  Berdasarkan penelitian yang telah dilakukan sebelumnya, perilaku merokok dapat menurunkan subjective well-being. untuk mengetahui perilaku merokok dengan subjective well-being pada mahasiswa sarjana pendidikan dokter dalam menghadapi pembelajaran tatap muka. Jenis penelitian kuantitatif dengan desain survei analitik dan rancangan cross-sectional. Sampel penelitian berjumlah 139 mahasiswa kedokteran di Bandar Lampung. Alat ukur yang digunakan adalah data demografi mahasiswa dan Positive Affect Negative Affect Schedule (PANAS), Satisfaction With Life Scale (SWLS) dan Health Promoting Lifestyle Profile II (HPLP II). sebagian besar responden memiliki tingkat perilaku merokok ringan (80,6%) dan subjective well-being (38,8%). Hasil analisis korelasi didapatkan p-value 0,000. terdapat korelasi perilaku merokok dengan subjective well-being pada mahasiswa sarjana pendidikan dokter dalam menghadapi pembelajaran tatap muka di Bandar Lampung

Hadoop File System with Elastic Replication Management: An Overview

ABSTRACT-This paper gives an overview of how Hadoop File System manages massive data as well as handles small files. As data is exponentially pouring in from all sides in all domains, it has become a necessity to manage and analyze such huge amount of data to extract useful information. This huge amount of data is technically termed as Big Data, which in turn falls under Data Science. Currently a lot of research is going on how to handle such vast pool of data. The Apache Hadoop is a software framework that uses simple programming paradigm to process and analyze large data sets(Big Data) across clusters of computers. The Hadoop Distributed File System(HDFS) is one such technology that manages the Big Data efficiently. In this paper, an insight of "how HDFS handles big as well as small amount of data" is presented, reviewed and analyzed. As a result, summarized limitations of existing sys-tems are described in the paper along with the future scope of it

Phytochemical profile and antioxidant potential of extracts of Callicarpa macrophylla Vahl. from Uttarakhand Himalayan region

The medicinal traits of Callicarpa macrophylla Vahl. have been used in traditional and folklore medicinal system, however, scientific evaluation of such medicinal plants have not been much explored yet. Different solvent extracts of the whole plant of C. macrophylla from the Himalayan region are the key subject of interest to evaluate and exhibit their antioxidant properties concerning its phytochemical composition. The different polarity extracts of C. macrophylla were prepared using the Soxhlet apparatus and both of their GC-MS profile outlined their individual components. The antioxidant activity of both extracts was evaluated for DPPH radical scavenging activity, metal chelating activity, and reducing power activity. Thirty-two compounds were identified in the hexane extract, accounting for 63.56% of the total extract composition with tetratetracontane (9.78%), as the prominent compound. A sum of 26 compounds making up 79.74% of the total methanolic extract composition was identified and the major compound was a diterpenoid, trachylobane (31.87%). The methanolic extract exerted potent antioxidant properties when compared, in vitro, to hexane extract as it showed better IC50 values of DPPH radical scavenging activity (91.97 ± 0.33 µg/ml), metal chelating activity (10.90 ± 1.40 µg/ml) and reducing power activity (56.72 ± 0.67 µg/ml). The antioxidant potential of the methanolic extract was also comparable to standards. Therefore, the methanolic extract exhibited better results as compared to hexane extract and had comparable potential with standards in vitro, if further explored might be utilized as an antioxidant agent in various pharmaceutical and cosmetic industries

Horizontally scalable probabilistic generalized suffix tree (PGST) based route prediction using map data and GPS traces

Abstract Route prediction is an essential requirement for many intelligent transport systems (ITS) services like VANETS, traffic congestion estimation, resource prediction in grid computing etc. This work focuses on building an end-to-end horizontally scalable route prediction application based on statistical modeling of user travel data. Probabilistic suffix tree (PST) is one of widely used sequence indexing technique which serves a model for prediction. The probabilistic generalized suffix tree (PGST) is a variant of PST and is essentially a suffix tree built from a huge number of smaller sequences. We construct generalized suffix tree model from a large number of trips completed by the users. User trip raw GPS traces is mapped to the digitized road network by parallelizing map matching technique leveraging map reduce framework. PGST construction from the huge volume of data by processing sequentially is a bottleneck in the practical realization. Most of the existing works focused on time-space tradeoffs on a single machine. Proposed technique solves this problem by a two-step process which is intuitive to execute in the map-reduce framework. In the first step, computes all the suffixes along with their frequency of occurrences and in the second step, builds probabilistic generalized suffix tree. The probabilistic aspect of the tree is also taken care so that it can be used as a model for prediction application. Dataset used are road network spatial data and GPS traces of users. Experiments carried out on real datasets available in public domain

A study to assess and evaluate the gingival response during and after the fixed orthodontics treatment experienced by adult patients

Objective: The purpose of this research was to examine patients' periodontal health before, during, and after treatment using a fixed orthodontic device. Methods: Forty normal teenagers with full sets of permanent teeth and a clinical need for fixed orthodontics participated. Individuals were chosen from the Class I population who would benefit from utilizing traditional orthodontic braces and techniques that did not need extractions. Respondents were sent to the periodontist for required checkups after the placement of a fixed orthodontic device at 3-, 6-, 12-, and 24-month intervals, respectively, till the conclusion of orthodontic treatment. Results: After having a fixed orthodontic device put in place, patients had a rise in the average values of the Plaque Index and Sulcus Bleeding Index at each checkup. Keeping an eye on the progression three months, six months, a year, and two years after the initiation of orthodontic treatment reveals a statistically significant difference in the presence of gingival hyperplasia. Conclusion: Patients' periodontal health before, during, and after fixed orthodontic treatment shows the need for close collaboration between the orthodontist and the periodontis

A study to assess knowledge, attitude, and perception of dental practitioners on minimally invasive dentistry concepts

Background: Minimally invasive dentistry (MID) includes caries detection using caries risk assessment (CRA), early localization of nascent carious sores including necessary and voluntary avoidance, and remineralization of demineralized veneer and dentin when diagnosed early for these reasons. Although the dentistry curriculum prioritizes the benefits of MID in tooth protection, this research is seldom included in classroom instruction. Aim: The purpose of this research was to gauge the level of understanding that dental professionals have about MID ideas. Methods: An online questionnaire measuring MID knowledge and application was used to compile the data. The Chi-square tests were run for statistical analysis in the Statistical Package for the Social Sciences (SPSS). Results: Just 42.2% of the dentists who replied had MID training during their undergraduate or internship years, and the majority of that training came via lectures (45.2%). The majority (almost 81%) of respondents believed that CRA should be performed on all patients. Differences in knowledge and experience with atraumatic restorative therapy and the sandwich approach for treating caries in permanent teeth and high caries risk children were shown to be statistically significant (P 0.05). Conclusion: Dentists know about the benefits of MID, but their patients are not reaping those benefits since so many dentists still use the old methods of treating complete caries

Rv3416 synergizes with Nef sufficient HIV but not Nef deficient HIV to inhibit apoptosis in macrophages.

<p>PMA stimulated THP1 cells were stimulated with 1 μg/ml Pam3CSK4 (Pam) and infected with 0.5 MOI of wild type HIV or Nef deficient HIV (HIVδNef) or Vpu deficient HIV (HIVδVpu) in the presence or absence of 20 μg/ml Rv3416 for 48h. Cells were stained with Annexin V-APC. Thin lines represent stimulation with Pam3CSK4 alone and the thick lines represent stimulation as indicated. Data from one of three independent experiments are shown. Bar graphs show relative MFIs of the histograms. Data from one of three experiments are shown. P<0.03 for Pam vs Pam+Rv3416. P<0.04 for Pam vs Pam+HIV, P<0.03for Pam vs Pam+Rv3416+HIV.</p

Reciprocal regulation of oxidative burst and calcium routing regulate apoptosis in macrophages by Rv3416 and Nef.

<p>For Panel A and B, PMA stimulated THP1 cells were treated with 50 μM H₂O₂ for 1h and stimulated with 1 μg/ml Pam3CSK4 along with 20 μg/ml Rv3416 and 15 μg/ml Nef for 24h. For Panel A, cells were stained with Annexin V-APC. Thin lines represent cells stimulated in the absence of H₂O₂ while the thick lines represent cells stimulated in the presence of H₂O₂. Data from one of three independent experiments are shown. Bar graphs adjacent to histogram in Panel A show relative MFIs of the histogram. For Panel B, PMA stimulated THP1 cells were stimulated with 1 μg/ml Pam3CSK4 along with 20 μg/ml Rv3416 or 15 μg/ml Nef or both for 24h and cytoplasmic extracts were probed for indicated molecules and analyzed by western blots. Numbers below the blots indicate the relative intensities of the bands. Data from one of three experiments are shown. For Panel C (PMA stimulated THP1 macrophages) and Panel E (Blood macrophages) were stimulated with 1 μg/ml Pam3CSK4 along with 20 μg/ml Rv3416 (dotted lines) or 15 μg/ml Nef (thin lines) or both (thick lines) for 2h for measuring oxidative burst. Thirty minutes prior to the incubation period, cells were loaded with 10μM DCFH-DA. At the end of the incubation period, cells were thoroughly washed with the culture medium and immediately analyzed for ROS levels by flow cytometry. Shaded histograms in Panel C and E represent cells stimulated with 1 μg/ml Pam3CSK4 only. Bar graphs adjacent to histograms in Panel C and Panel D show relative MFIs of the corresponding histograms. For Panel D (THP-1 macrophages) and Panel F (Blood macrophages) cells stimulated with 1 μg/ml Pam3CSK4 along with 20 μg/ml Rv3416 and 15 μg/ml Nef with or without EGTA or TMB-8 for 1h and ROS levels were measured. In Panel C P<0.004 for Pam vs Pam+Rv3416+Nef; In Panel D, P<0.005 for Pam+Rv3416+Nef vs Pam+Rv3416+Nef+TMB; P<0.005 for Pam+Rv3416+Nef vs Pam+Rv3416+Nef+EGTA. In Panel E, P<0.03 for Pam vs Pam+Rv3416+Nef; In Panel F, P<0.05 for Pam+Rv3416+Nef vs Pam+Rv3416+Nef+TMB; P<0.04 for Pam+Rv3416+Nef vs Pam+Rv3416+Nef+EGTA.</p