2,980 research outputs found
Continuous transition of social efficiencies in the stochastic strategy Minority Game
We show that in a variant of the Minority Game problem, the agents can reach
a state of maximum social efficiency, where the fluctuation between the two
choices is minimum, by following a simple stochastic strategy. By imagining a
social scenario where the agents can only guess about the number of excess
people in the majority, we show that as long as the guess value is sufficiently
close to the reality, the system can reach a state of full efficiency or
minimum fluctuation. A continuous transition to less efficient condition is
observed when the guess value becomes worse. Hence, people can optimize their
guess value for excess population to optimize the period of being in the
majority state. We also consider the situation where a finite fraction of
agents always decide completely randomly (random trader) as opposed to the rest
of the population that follow a certain strategy (chartist). For a single
random trader the system becomes fully efficient with majority-minority
crossover occurring every two-days interval on average. For just two random
traders, all the agents have equal gain with arbitrarily small fluctuations.Comment: 8 pages, 6 fig
Phase transitions in crowd dynamics of resource allocation
We define and study a class of resources allocation processes where
agents, by repeatedly visiting resources, try to converge to optimal
configuration where each resource is occupied by at most one agent. The process
exhibits a phase transition, as the density of agents grows, from an
absorbing to an active phase. In the latter, even if the number of resources is
in principle enough for all agents (), the system never settles to a
frozen configuration. We recast these processes in terms of zero-range
interacting particles, studying analytically the mean field dynamics and
investigating numerically the phase transition in finite dimensions. We find a
good agreement with the critical exponents of the stochastic fixed-energy
sandpile. The lack of coordination in the active phase also leads to a
non-trivial faster-is-slower effect.Comment: 7 pages, 7 fig
Taking Blockchain Seriously
In the present techno-political moment it is clear that ignoring or dismissing the hype surrounding blockchain is unwise, and certainly for regulatory authorities and governments who must keep a grip on the technology and those promoting it, in order to ensure democratic accountability and regulatory legitimacy within the blockchain ecosystem and beyond. Blockchain is telling (and showing) us something very important about the evolution of capital and neoliberal economic reason, and the likely impact in the near future on forms and patterns of work, social organization, and, crucially, on communities and individuals who lack influence over the technologies and data that increasingly shape and control their lives. In this short essay I introduce some of the problems in the regulation of blockchain and offer counter-narratives aimed at cutting through the hype fuelling the ascendency of this most contemporary of technologies
Low plasma citrulline levels are associated with acute respiratory distress syndrome in patients with severe sepsis
INTRODUCTION: The role of nitric oxide synthase (NOS) in the pathophysiology of acute respiratory distress syndrome (ARDS) is not well understood. Inducible NOS is upregulated during physiologic stress; however, if NOS substrate is insufficient then NOS can uncouple and switch from NO generation to production of damaging peroxynitrites. We hypothesized that NOS substrate levels are low in patients with severe sepsis and that low levels of the NOS substrate citrulline would be associated with end organ damage including ARDS in severe sepsis. METHODS: Plasma citrulline, arginine and ornithine levels and nitrate/nitrite were measured at baseline in 135 patients with severe sepsis. ARDS was diagnosed by consensus definitions. RESULTS: Plasma citrulline levels were below normal in all patients (median 9.2 uM, IQR 5.2 - 14.4) and were significantly lower in ARDS compared to the no ARDS group (6.0 (3.3 - 10.4) vs. 10.1 (6.2 - 16.6), P = 0.002). The rate of ARDS was 50% in the lowest citrulline quartile compared to 15% in the highest citrulline quartile (P = 0.002). In multivariable analyses, citrulline levels were associated with ARDS even after adjustment for covariates including severity of illness. CONCLUSIONS: In severe sepsis, levels of the NOS substrate citrulline are low and are associated with ARDS. Low NOS substrate levels have been shown in other disease states to lead to NOS uncoupling and oxidative injury suggesting a potential mechanism for the association between low citrulline and ARDS. Further studies are needed to determine whether citrulline supplementation could prevent the development of ARDS in patients with severe sepsis and to determine its role in NOS coupling and function
Challenges in Columbia River Fisheries Conservation: A Response to Duda et al.
The salmonid fisheries of the Columbia River Basin (CRB) have enormous socioeconomic, cultural, and ecological importance to numerous diverse stakeholders (eg state, federal, tribal, nonprofit), and there are a wide array of opinions and perspectives on how these fisheries should be managed. Although we appreciate Duda et al.\u27s commentary, it offers only one perspective of many in this context. The objective of our paper (Hand et al. 2018) was to provide justification for “the importance of social–ecological perspectives when communicating conservation values and goals, and the role of independent science in guiding management policy and practice for salmonids in the CRB”. However, we did not intend to strictly advocate for a single course of action, and the available space within our paper\u27s Panel 1 limited us from engaging in a thorough ecological debate
Loss of the Nutrient Sensor Tas1R3 Leads to Reduced Bone Resorption
Background: The Taste receptor, type 1 (TAS1R) family of heterotrimeric G protein-coupled receptors participates in monitoring energy and nutrient needs. TAS1R member 3 (TAS1R3) either recognizes amino acids such as glycine and L-glutamate or sweet molecules such as sucrose and fructose when dimerized with TAS1R member 1 (TAS1R1) or TAS1R member 2 (TAS1R2), respectively. Loss of TAS1R3 expression can cause impaired mTORC1 signaling and increased autophagy, indicating that signaling through this receptor is critical for assessing nutrient needs. Recently, it was reported that global deletion of TAS1R3 expression in Tas1R3 mutant mice leads to increased cortical bone mass and trabecular remodeling but the underlying cellular mechanism leading to this phenotype remains unclear. Results: To address this open question, we quantified bone turnover markers in serum from 20-week-old wild type and Tas1R3 mutant mice and found that levels of the resorption marker Collagen Type I C-telopeptide (CTx) were reduced on average by \u3e60% in the absence of TAS1R3 expression. Levels of the bone formation marker Procollagen Type I N-terminal Propeptide (P1NP) tend to be higher in Tas1R3 mutant mice but this finding did not reach statistical significance (
Artificial economic life: a simple model of a stockmarket
We describe a model of a stockmarket in which independent adaptive agents can buy and sell stock on a central market. The overall market behavior, such as the stock price time series, is an emergent property of the agents' behavior. This approach to modelling a market is contrasted with conventional rational expectations approaches. Our model does not necessarily converge to an equilibrium, and can show bubbles, crashes, and continued high trading volume.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/31402/1/0000319.pd
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