Aging Kit Mutant Mice Develop Cardiomyopathy

Both bone marrow (BM) and myocardium contain progenitor cells expressing the c-Kit tyrosine kinase. The aims of this study were to determine the effects of c-Kit mutations on: i. myocardial c-Kit+ cells counts and ii. the stability of left ventricular (LV) contractile function and structure during aging. LV structure and contractile function were evaluated (echocardiography) in two groups of Kit mutant (W/Wv and W41/W42) and in wild type (WT) mice at 4 and 12 months of age and the effects of the mutations on LV mass, vascular density and the numbers of proliferating cells were also determined. In 4 month old Kit mutant and WT mice, LV ejection fractions (EF) and LV fractional shortening rates (FS) were comparable. At 12 months of age EF and FS were significantly decreased and LV mass was significantly increased only in W41/W42 mice. Myocardial vascular densities and c-Kit+ cell numbers were significantly reduced in both mutant groups when compared to WT hearts. Replacement of mutant BM with WT BM at 4 months of age did not prevent these abnormalities in either mutant group although they were somewhat attenuated in the W/Wv group. Notably BM transplantation did not prevent the development of cardiomyopathy in 12 month W41/W42 mice. The data suggest that decreased numbers and functional capacities of c-Kit+ cardiac resident progenitor cells may be the basis of the cardiomyopathy in W41/W42 mice and although defects in mutant BM progenitor cells may prove to be contributory, they are not causal

Die Fruchtbarkeits- und Sterblichkeitsverhältnisse in sämmtlichen Städten Sachsens während des Jahrfünfts 1881 bis 1885

von Arthur GeisslerAus: Zeitschrift des Königl. Sächsischen Statistischen Bureaus ; 1887,1/

Supporting part-time teaching staff in higher education: perspectives from business and health.

This report arises from the findings of the Higher Education Academy Joint Subject CentreDevelopment Project Supporting Part-Time Teaching Staff in Higher Education, which wasconducted between November 2006 and November 2008 on behalf of the BusinessManagement Accountancy and Finance, and Health Sciences and Practice Subject Centres.Part-time teachers (PTTs) account for a substantial proportion of the UK academic labourmarket in the general fields of business and management, and health care. The focus of thisproject was PTTs who were mid-career professionals and experienced managers,consultants or clinical experts: the dominant group from which PTTs in these two fields aredrawn. For this reason, graduate teaching assistants and contract researchers who mightundertake part-time teaching were excluded from the stud

Supporting part-time teaching staff in higher education: perspectives from business and health.

This report arises from the findings of the Higher Education Academy Joint Subject CentreDevelopment Project Supporting Part-Time Teaching Staff in Higher Education, which wasconducted between November 2006 and November 2008 on behalf of the BusinessManagement Accountancy and Finance, and Health Sciences and Practice Subject Centres.Part-time teachers (PTTs) account for a substantial proportion of the UK academic labourmarket in the general fields of business and management, and health care. The focus of thisproject was PTTs who were mid-career professionals and experienced managers,consultants or clinical experts: the dominant group from which PTTs in these two fields aredrawn. For this reason, graduate teaching assistants and contract researchers who mightundertake part-time teaching were excluded from the stud