2-Chloro-4-(2-iodo­benzene­sulfonamido)­benzoic acid

In the title compound, C13H9ClINO4S, the dihedral angle between the aromatic rings is 81.04 (17)°. The disposition of the I and Cl atoms attached to the two rings is anti. In the crystal, mol­ecules are connected via O—H⋯O and N—H⋯O hydrogen bonds

Study of effect of Nigella sativa on prevention of nephrotoxicity induced by colistin in experimental animals

ABSTRACTBackground: Nigella sativa, a widely used medicinal plant throughout the world belongs to family ranunculaceae. Its Seeds and oil have a long history of folklore usage in various traditional systems of medicines and food. This study was performed to evaluate the protective effect of Nigella sativa oil (NSO) on kidney when simultaneously given with colistin sulfate (CS) which induces tubular damage in rats.Methods: Animals were treated for 7 days: Group I (n=6) with normal saline and CMC, Group II, III and IV with 300.000IU/kg/day of CS (n=6). Group III and Group IV with NSO at the dose of 1 and 2ml/kg per orum prior to CS administration. All the animals were sacrificed on 8th day. Afterwards, the plasma creatinine (pCr), blood urea, renal tissue level of malondialdehyde (MDA), reduced glutathione (GSH) and renal histology were performed.Results: Colistin sulfate induced tubular damage, increased the plasma creatinine (pCr), blood urea and MDA levels and decreased the reduced glutathione (GSH). However, simultaneous treatment with Nigella sativa oil at the dose of 1ml/kg and 2ml/kg for one week produced dose dependant improvement in tubular damage and reduced the biochemical alteration.Conclusions: It could be concluded that, Colistin sulfate induced nephrotoxicity is ameliorated by NS oil especially in higher dose of (2ml/kg). This nephroprotective effect is ascribed to free radical scavenging and potent antioxidant activity in Nigella sativa

4-Chloro-1-iodo-2-nitro­benzene

In the mol­ecule of the title compound, C6H3ClINO2, the nitro group is disordered over two sites with occupancies of 0.506 (6) and 0.494 (6). The dihedral angles between the benzene ring and the two disordered components of the nitro group are 29.0 (2) and 51.0 (3)°. The disordering avoids short O⋯O inter­molecular contacts in the crystal

Methyl 4-hy­droxy-2-meth­oxy­carbonyl­methyl-1,1-dioxo-1,2-dihydro-1λ6,2-benzothia­zine-3-carboxyl­ate1

There are two independent mol­ecules in the asymmetric unit of the title compound, C13H13NO7S, which have almost identical geometries. The thia­zine ring adopts a sofa conformation in both mol­ecules and the mol­ecular conformations are stabilized by intramolecular O—H⋯O hydrogen bonds. Inter­molecular C—H⋯O hydrogen bonds stabilize the crystal packing

2-Chloro-5-(2-iodo­benzene­sulfonamido)­benzoic acid

In the mol­ecule of the title compound, C13H9ClINO4S, the coordination around the S atom is distorted tetra­hedral. The aromatic rings are oriented at a dihedral angle of 74.46 (9)°. Intra­molecular C—H⋯O hydrogen bonds result in the formation of two five- and one six-membered rings, which adopt planar, envelope and twisted conformations, respectively. In the crystal structure, inter­molecular N—H⋯O and O—H⋯O hydrogen bonds link the mol­ecules to form R 2 2(8) ring motifs, which are further linked by C—H⋯O hydrogen bonds. π–π contacts between the benzene rings [centroid–centroid distances = 3.709 (3) and 3.772 (3) Å] may further stabilize the structure. The I atom is disordered over two positions, refined with occupancies of ca 0.75 and 0.25

2-Bromo-4-nitro­aniline

In the mol­ecule of the title compound, C6H5BrN2O2, the dihedral angle between the nitro group and the aromatic ring is 4.57 (4)°. An intra­molecular N—H⋯Br inter­action results in the formation of a planar five-membered ring, which is oriented with respect to the aromatic ring at a dihedral angle of 1.64 (6)°. In the crystal structure, inter­molecular N—H⋯N and N—H⋯O hydrogen bonds link the mol­ecules

6-Bromo-1-methyl-1H-2,1-benzothia­zin-4(3H)-one 2,2-dioxide

In the crystal structure of the title compound, C9H8BrNO3S, the thia­zine ring is in the twisted form. In the crystal, pairs of inter­molecular C—H⋯O hydrogen bonds form inversion dimers with an R 2 2(8) ring motif. Weak inter­molecular C—H⋯Br and C—H⋯π inter­actions are also present

Methyl 4-hy­droxy-2-isopropyl-1,1-dioxo-2H-1,2-benzothia­zine-3-carboxyl­ate

In the crystal structure of the title mol­ecule, C13H15NO5S, the S and N atoms of the thia­zine ring exihibit the maximum deviations from the least-squares plane of 0.3008 (6) and 0.3280 (7) Å, respectively. The ring therefore adopts a half chair conformation. The thia­zine ring is twisted by an angle of 13.29 (7)° with respect to the aromatic ring. The isopropyl substituent is oriented at a dihedral angle of 53.2 (12)° with respect to the thia­zine ring. An intra­molecular O—H⋯O hydrogen bond occurs. Inter­molecular hydrogen bonding is observed in the crystal structure

N-Acetyl-4-(benzene­sulfonamido)benzene­sulfonamide

In the mol­ecule of the title compound, C14H14N2O5S2, the dihedral angle between the aromatic rings is 77.75 (9)°. The acetamide group is planar [maximum deviation = 0.002 (3) Å] and oriented at dihedral angles of 13.49 (21) and 73.94 (10)° with respect to the aromatic rings. An intra­molecular C—H⋯O inter­action results in the formation of a six-membered ring. In the crystal structure, inter­molecular N—H⋯O and C—H⋯O inter­actions link the mol­ecules into a three-dimensional network, forming R 2 2(20) ring motifs