Antimatter and Matter Production in Heavy Ion Collisions at CERN (The NEWMASS Experiment NA52)

Besides the dedicated search for strangelets NA52 measures light (anti)particle and (anti)nuclei production over a wide range of rapidity. Compared to previous runs the statistics has been increased in the 1998 run by more than one order of magnitude for negatively charged objects at different spectrometer rigidities. Together with previous data taking at a rigidity of -20 GeV/c we obtained 10^6 antiprotons 10^3 antideuterons and two antihelium3 without centrality requirements. We measured nuclei and antinuclei (p,d,antiprotons, antideuterons) near midrapidity covering an impact parameter range of b=2-12 fm. Our results strongly indicate that nuclei and antinuclei are mainly produced via the coalescence mechanism. However the centrality dependence of the antibaryon to baryon ratios show that antibaryons are diminished due to annihilation and breakup reactions in the hadron dense environment. The volume of the particle source extracted from coalescence models agrees with results from pion interferometry for an expanding source. The chemical and thermal freeze-out of nuclei and antinuclei appear to coincide with each other and with the thermal freeze-out of hadrons.Comment: 12 pages, 8 figures, to appear in the proceedings of the conference on 'Fundamental Issues in Elementary Matter' Bad Honnef, Germany, Sept. 25-29, 200

Monotonicity of quantum ground state energies: Bosonic atoms and stars

The N-dependence of the non-relativistic bosonic ground state energy is studied for quantum N-body systems with either Coulomb or Newton interactions. The Coulomb systems are "bosonic atoms," with their nucleus fixed, and the Newton systems are "bosonic stars". In either case there exists some third order polynomial in N such that the ratio of the ground state energy to the respective polynomial grows monotonically in N. Some applications of these new monotonicity results are discussed

Warm strange hadronic matter in an effective model with a weak Y-Y interaction

An effective model is used to study the equation of state of warm strange hadronic matter with nucleons, Lambda-hyperons, Xi-hyperons, sigmastar and phi. In the calculation, a newest weak Y-Y interaction deduced from the recent observation of a He double hypernucleus is adopted. Employing this effective model, the results with strong Y-Y interaction and weak Y-Y interaction are compared.Comment: 9 pages, 9 figure

Violation of energy-per-hadron scaling in a resonance matter

Yields of hadrons, their average masses and energies per hadron at the stage of chemical freeze-out in (ultra)relativistic heavy-ion collisions are analyzed within the statistical model. The violation of the scaling / = 1 GeV observed in Au+Au collisions at $\sqrt{s}$ = 130 AGeV is linked to the formation of resonance-rich matter with a considerable fraction of baryons and antibaryons. The rise of the energy-per-hadron ratio in baryon-dominated matter is discussed. A violation of the scaling condition is predicted for a very central zone of heavy-ion collisions at energies around 40 AGeV.Comment: 5 pages incl. 3 figures and 2 tables, to be published in Phys. Rev.

Charged pion production in fixed target Pb + Pb collisions at 158 GeV per nucleon

Changes in pion production as a function of the impact parameter of the collision or the incident energy, may reveal characteristics of a possible first-order phase transition from nuclear to quark matter, as predicted by lattice quantum chromodynamics. In this paper we investigate charged pion production in Pb+Pb collisions at 158 GeV/nucleon near 0° production angle and at forward rapidity $(4.3\leq y \leq 6.3)$. The centrality dependence of pion production is shown in the impact parameter range ~ 2-12 fm at the rapidities y = 5.7 and 6.3. An enhancement in the pi-/pi+ ratio has been measured near beam rapidity, indicating Coulomb interaction of charged pions with the spectator protons. The charged pion yield per nucleon participating in the collision (N_p) at y = 5.7 increases faster than linearly with N_p, up to N_p~100 and then it saturates, while at y = 6.3 it does not exhibit any sudden change as a function of N_p

Pion yield from 450 GeV/c protons on beryllium

This paper reports on the charged pion production yields measured by the SPY/NA56 experiment for 450 GeV/c proton interactions on beryllium targets. The present data cover a secondary momentum range from 7 GeV/c to 135 GeV/c in the forward direction. An experimental accuracy ranging from 5 to 10\%, depending on the beam momentum, has been achieved, limited mainly by the knowledge of the beam acceptance. These results will be relevant in the calculation of neutrino fluxes in present and future neutrino beams

Ustekinumab as Induction and Maintenance Therapy for Crohn’s Disease

BACKGROUND Ustekinumab, a monoclonal antibody to the p40 subunit of interleukin-12 and inter-leukin-23, was evaluated as an intravenous induction therapy in two populations with moderately to severely active Crohn’s disease. Ustekinumab was also evaluated as subcutaneous maintenance therapy. METHODS We randomly assigned patients to receive a single intravenous dose of ustekinumab (either 130 mg or approximately 6 mg per kilogram of body weight) or placebo in two induction trials. The UNITI-1 trial included 741 patients who met the criteria for primary or secondary nonresponse to tumor necrosis factor (TNF) antagonists or had unacceptable side effects. The UNITI-2 trial included 628 patients in whom conventional therapy failed or unacceptable side effects occurred. Patients who completed these induction trials then participated in IM-UNITI, in which the 397 patients who had a response to ustekinumab were randomly assigned to receive subcutaneous maintenance injections of 90 mg of ustekinumab (either every 8 weeks or every 12 weeks) or placebo. The primary end point for the induction trials was a clinical response at week 6 (defined as a decrease from baseline in the Crohn’s Disease Activity Index [CDAI] score of ≥100 points or a CDAI score <150). The primary end point for the maintenance trial was remission at week 44 (CDAI score <150). RESULTS The rates of response at week 6 among patients receiving intravenous ustekinumab at a dose of either 130 mg or approximately 6 mg per kilogram were significantly higher than the rates among patients receiving placebo (in UNITI-1, 34.3%, 33.7%, and 21.5%, respectively, with P≤0.003 for both comparisons with placebo; in UNITI-2, 51.7%, 55.5%, and 28.7%, respectively, with P<0.001 for both doses). In the groups receiving maintenance doses of ustekinumab every 8 weeks or every 12 weeks, 53.1% and 48.8%, respectively, were in remission at week 44, as compared with 35.9% of those receiving placebo (P = 0.005 and P = 0.04, respectively). Within each trial, adverse-event rates were similar among treatment groups. CONCLUSIONS Among patients with moderately to severely active Crohn’s disease, those receiving intravenous ustekinumab had a significantly higher rate of response than did those receiving placebo. Subcutaneous ustekinumab maintained remission in patients who had a clinical response to induction therapy. (Funded by Janssen Research and Development; ClinicalTrials.gov numbers, NCT01369329, NCT01369342, and NCT01369355.

Endocrine disruptors and obesity

The purpose of this review is to summarise current evidence that some environmental chemicals may be able to interfere in endocrine regulation of energy metabolism and adipose tissue structure. Recent findings demonstrate that such endocrine disrupting chemicals, termed “obesogens”, can promote adipogenesis and cause weight gain. This includes compounds to which the human population is exposed in daily life through their use in pesticides/herbicides, industrial and household products, plastics, detergents, flame retardants and ingredients in personal care products. Animal models and epidemiological studies have shown that an especially sensitive time for exposure is in utero or the neonatal period. In summarising the actions of obesogens, it is noteworthy that as their structures are mainly lipophilic, their ability to increase fat deposition has the added consequence of increasing the capacity for their own retention. This has the potential for a vicious spiral not only of increasing obesity but also increasing retention of other lipophilic pollutant chemicals with an even broader range of adverse actions. This might offer an explanation as to why obesity is an underlying risk factor for so many diseases including cancer

Effect of Systemic Hypertension With Versus Without Left Ventricular Hypertrophy on the Progression of Atrial Fibrillation (from the Euro Heart Survey).

Hypertension is a risk factor for both progression of atrial fibrillation (AF) and development of AF-related complications, that is major adverse cardiac and cerebrovascular events (MACCE). It is unknown whether left ventricular hypertrophy (LVH) as a consequence of hypertension is also a risk factor for both these end points. We aimed to assess this in low-risk AF patients, also assessing gender-related differences. We included 799 patients from the Euro Heart Survey with nonvalvular AF and a baseline echocardiogram. Patients with and without hypertension were included. End points after 1 year were occurrence of AF progression, that is paroxysmal AF becoming persistent and/or permanent AF, and MACCE. Echocardiographic LVH was present in 33% of 379 hypertensive patients. AF progression after 1 year occurred in 10.2% of 373 patients with rhythm follow-up. In hypertensive patients with LVH, AF progression occurred more frequently as compared with hypertensive patients without LVH (23.3% vs 8.8%, p = 0.011). In hypertensive AF patients, LVH was the most important multivariably adjusted determinant of AF progression on multivariable logistic regression (odds ratio 4.84, 95% confidence interval 1.70 to 13.78, p = 0.003). This effect was only seen in male patients (27.5% vs 5.8%, p = 0.002), while in female hypertensive patients, no differences were found in AF progression rates regarding the presence or absence of LVH (15.2% vs 15.0%, p = 0.999). No differences were seen in MACCE for hypertensive patients with and without LVH. In conclusion, in men with hypertension, LVH is associated with AF progression. This association seems to be absent in hypertensive women

Centrality dependence of K+ produced in Pb+Pb collisions at 158 GeV per nucleon

The NA52 collaboration searches for a discontinuous behaviour of charged kaons produced in Pb+Pb collisions at 158 A GeV as a function of the impact parameter, which could reveal a hadron to quark-gluon plasma (QGP) phase transition. The K+ yield is found to grow proportional to the number of participating ('wounded') nucleons N, above N=100. Previous NA52 data agree with the above finding and show a discontinuous behaviour in the kaon centrality dependence near N=100, marking the onset of strangeness enhancement -over e.g. p+A data at the same \sqrt{s}- in a chemically equilibrated phase.Comment: 2 pages, 2 figures, submitted to the XXXth International Conference on High Energy Physics, 27 July - 2 August, 2000, Osaka, Japa