Effects of In-bed Stoichiometric and Flue Gas Recirculation on Combustion and Environmental Performances of a Swirling Fluidized-bed Combustor

This work studied the firing of ground nut/peanut shells in a twin-cyclonic fluidized-bed combustor at the maximum combustor loading (~22.5 kg/h) in the flue gas recirculation (FGR) mode. During the experimental tests, excess air (EA) was fixed at about 60%, while the in-bed stoichiometric ratio (Sb) and FGR ranged from 1.0–1.2 and from 10–25%, respectively. The experimental results showed that nitrogen oxide (NOx) emissions significantly decreased when FGR increased; however, the opposite tendency was found for carbon monoxide (CO) emission. Meanwhile, FGR showed strong effects on both combustion and emission performances, the impacts of Sb were quite low. The FGR of ~10-18% and Sb from 1.0-1.2 appear to be optimum operating conditions for firing ground nut/peanut shells to ensure the lowering of major emissions under the limitations of Thailand’s emission standards, with high combustor efficiency at 99%

Comparative life cycle assessment of pelletized biomass fuels from corncobs and rubberwood sawdust

This study investigates and compares the environmental impacts of pelletized biomass fuel production from corn cobs and rubberwood sawdust using the Life Cycle Assessment (LCA) methodology across the entire cradle-to-grave process. The assessment encompasses raw material acquisition, production, industrial use, and transportation. Data were collected on resource usage, energy consumption, water usage, and greenhouse gas (GHG) emissions, with the functional unit set as 1 ton of steam generated by a steam generator. Environmental impacts were evaluated using the CML (baseline) 2015 method in openLCA software, with data drawn from the Ecoinvent 3.4 database. Comparisons with other biomass types were also included. The findings indicate that corn cobs are a preferable raw material for pelletized biomass production compared to rubberwood sawdust, as they require less electricity and fewer resources across the lifecycle due to a simpler production process. The study reveals that the highest environmental impacts occur during biomass pellet production, particularly in rubberwood processing, which is energy intensive. Climate change impacts are most significant in the steam production stage, attributed to GHG emissions from biomass pellet combustion. Furthermore, fossil fuels used in other processes and transportation contribute to the overall environmental footprint. Mitigating these impacts would benefit from enhancing energy efficiency, reducing GHG emissions, and expanding the use of renewable energy in production processes. These measures could substantially lessen the environmental effects associated with pelletized biomass fuel production. The impact of data uncertainties in steam production from biomass pellets was assessed through sensitivity analysis. Four key parameters were identified as having significant variability, including transportation of pellets from production plants to steam plants, corn kernel selling price, natural rubber selling price, and allocation method. The transportation distance and agricultural product prices (corn kernel and natural rubber) introduce minimal uncertainty into the LCA results within the tested range (±10%)

State government effects on the spatial distribution of inward foreign direct investment

In a recent review of the literature, Wasylenko (1981) concluded that taxes have very little effect on interregional business location decisions. The present study examines the impact of state taxes and incentive programs on the spatial distribution of inward foreign direct investment in manufacturing. The results reveal that taxes, which were measured in various ways, deter foreign direct investment. Conversely, states providing tax incentives, financial assistance, and employment assistance tended to have larger numbers of foreign direct investments.Investments, Foreign - United States ; Taxation ; Industries

State characteristics and the location of foreign direct investment within the United States: a linear conditional logit model

Investments, Foreign - United States

Familial aggregation of gout and relative genetic and environmental contributions: a nationwide population study in Taiwan

OBJECTIVE: To examine familial aggregation of gout and to estimate the heritability and environmental contributions to gout susceptibility in the general population. METHODS: Using data from the National Health Insurance (NHI) Research Database in Taiwan, we conducted a nationwide cross-sectional study of data collected from 22 643 748 beneficiaries of the NHI in 2004; among them 1 045 059 individuals had physician-diagnosed gout. We estimated relative risks (RR) of gout in individuals with affected first-degree and second-degree relatives and relative contributions of genes (heritability), common environment shared by family members and non-shared environment to gout susceptibility. RESULTS: RRs for gout were significantly higher in individuals with affected first-degree relatives (men, 1.91 (95% CI 1.90 to 1.93); women, 1.97 (95% CI 1.94 to 1.99)) and also in those with affected second-degree relatives (men, 1.27 (95% CI 1.23 to 1.31); women, 1.40 (95% CI 1.35 to 1.46)). RRs (95% CIs) for individuals with an affected twin, sibling, offspring, parent, grandchild, nephew/niece, uncle/aunt and grandparent were 8.02 (6.95 to 9.26), 2.59 (2.54 to 2.63), 1.96 (1.95 to 1.97), 1.93 (1.91 to 1.94), 1.48 (1.43 to 1.53), 1.40 (1.32 to 1.47), 1.31 (1.24 to 1.39), and 1.26 (1.21 to 1.30), respectively. The relative contributions of heritability, common and non-shared environmental factors to phenotypic variance of gout were 35.1, 28.1 and 36.8% in men and 17.0, 18.5 and 64.5% in women, respectively. CONCLUSIONS: This population-based study confirms that gout aggregates within families. The risk of gout is higher in people with a family history. Genetic and environmental factors contribute to gout aetiology, and the relative contributions are sexually dimorphic

“Clinical features of women with gout arthritis.” A systematic review

Clinically, gout is generally considered as a preferential male disease. However, it definitely does not occur exclusively in males. Our aim was to assess differences in the clinical features of gout arthritis between female and male patients. Five electronic databases were searched to identify relevant original studies published between 1977 and 2007. The included studies had to focus on adult patients with primary gout arthritis and on sex differences in clinical features. Two reviewers independently assessed eligibility and quality of the studies. Out of 355 articles, 14 were selected. Nine fulfilled the quality and score criteria. We identified the following sex differences in the clinical features of gout in women compared to men: the onset of gout occurs at a higher age, more comorbidity with hypertension or renal insufficiency, more often use of diuretics, less likely to drink alcohol, less often podagra but more often involvement of other joints, less frequent recurrent attacks. We found interesting sex differences regarding the clinical features of patients with gout arthritis. To diagnose gout in women, knowledge of these differences is essential, and more research is needed to understand and explain the differences , especially in the general population

African American patients with gout: efficacy and safety of febuxostat vs allopurinol

<p>Abstract</p> <p>Background</p> <p>African Americans are twice as likely as Caucasians to develop gout, but they are less likely to be treated with urate-lowering therapy (ULT). Furthermore, African Americans typically present with more comorbidities associated with gout, such as hypertension, obesity, and renal impairment. We determined the efficacy and safety of ULT with febuxostat or allopurinol in African American subjects with gout and associated comorbidities and in comparison to Caucasian gout subjects.</p> <p>Methods</p> <p>This is a secondary analysis of the 6-month Phase 3 CONFIRMS trial. Eligible gouty subjects with baseline serum urate (sUA) ≥ 8.0 mg/dL were randomized 1:1:1 to receive febuxostat 40 mg, febuxostat 80 mg, or allopurinol (300 mg or 200 mg depending on renal function) daily. All subjects received gout flare prophylaxis. Primary efficacy endpoint was the proportion of subjects in each treatment group with sUA < 6.0 mg/dL at the final visit. Additional endpoints included the proportion of subjects with mild or with moderate renal impairment who achieved a target sUA < 6.0 mg/dL at final visit. Adverse events (AEs) were recorded throughout the study.</p> <p>Results</p> <p>Of the 2,269 subjects enrolled, 10.0% were African American and 82.1% were Caucasian. African American subjects were mostly male (89.5%), obese (BMI ≥ 30 kg/m²; 67.1%), with mean baseline sUA of 9.8 mg/dL and mean duration of gout of 10.4 years. The proportions of African American subjects with a baseline history of diabetes, renal impairment, or cardiovascular disease were significantly higher compared to Caucasians (<it>p </it>< 0.001). ULT with febuxostat 80 mg was superior to both febuxostat 40 mg (<it>p </it>< 0.001) and allopurinol (<it>p </it>= 0.004). Febuxostat 40 mg was comparable in efficacy to allopurinol. Significantly more African American subjects with mild or moderate renal impairment achieved sUA < 6.0 mg/dL in the febuxostat 80 group than in either the febuxostat 40 mg or allopurinol group (<it>p </it>< 0.05). Efficacy rates in all treatment groups regardless of renal function were comparable between African American and Caucasian subjects, as were AE rates.</p> <p>Conclusions</p> <p>In African American subjects with significant comorbidities, febuxostat 80 mg is significantly more efficacious than either febuxostat 40 mg or allopurinol 200/300 mg. Febuxostat was well tolerated in this African American population.</p> <p>Please see related article: <url>http://www.biomedcentral.com/1741-7015/10/15</url></p

Gout. Epidemiology of gout

Gout is the most prevalent form of inflammatory arthropathy. Several studies suggest that its prevalence and incidence have risen in recent decades. Numerous risk factors for the development of gout have been established, including hyperuricaemia, genetic factors, dietary factors, alcohol consumption, metabolic syndrome, hypertension, obesity, diuretic use and chronic renal disease. Osteoarthritis predisposes to local crystal deposition. Gout appears to be an independent risk factor for all-cause mortality and cardiovascular mortality and morbidity, additional to the risk conferred by its association with traditional cardiovascular risk factors