Show me the Semiosis: Grounding Post Structural Theory in Physiological Experience

Most of my art students experience a very down to earth epistemological relationship to the world. There is what there is. Middle America is a land of dualisms: matter and spirit, mind and body, good and evil. In this uncluttered black and white world, post-structural theory seemingly has little to offer but a range of unnecessary and unattractive grays. This presentation describes how I overcome my students’ resistance to intellectualizing perception and art making. I use a physiological perspective that grounds students’ investigation of art and meaning in an investigation of themselves, their bodies, their perceptual responses, emotional reactions and cognitive processes. I meet them where they are and lead them to “discover” polysemia, semiotics, deconstruction, pleasure in genre, the gaze, the over-estimation of consciousness and the myth of authorial intent. This physiological approach provides students with a set of critical frameworks to enrich their understanding of art, however, it also points to where theory often falls flat. Despite all of the decoding, associating and analyzing, it all comes back to a simple, irreducible relationship. There’s me and that thing in front of me. It doesn’t get much more down to earth then that

Multiproxy records of climate variability for Kamchatka for the past 400 years

International audienceTree rings, ice cores and glacial geologic histories for the past several centuries offer an opportunity to characterize climate variability and to identify the key climate parameters forcing glacier expansions. A newly developed larch ring-width chronology is presented for Kamchatka that is sensitive to past summer temperature variability. This record provides the basis to compare with other proxy records of inferred temperature and precipitation change from ice core and glacier records, and to characterize climate for the region over the past 400 years. Individual low growth years in the larch record are associated with several known and proposed volcanic events that have been observed in other proxy records from the Northern Hemisphere. Comparison of the tree-rings with an ice core record of melt feature index for Kamchatka's Ushkovsky volcano confirms a 1?3 year dating accuracy for this ice core series over the late 18th to 20th centuries. Decadal variations of low summer temperatures (tree-ring record) and high annual precipitation (ice core record) are broadly consistent with intervals of positive mass balance measured and estimated at several glaciers, and with moraine building, provides a basis to interpret geologic glacier records

Restorative Justice-Informed Moral Acquaintance: Resolving the Dual Role Problem in Correctional and Forensic Practice

The issue of dual roles within forensic and correctional fields has typically been conceptualized as dissonance—experienced by practitioners— when attempting to adhere to the conflicting ethical requirements associated with client well-being and community protection. In this paper, we argue that the dual role problem should be conceptualized more broadly; to incorporate the relationship between the offender and their victim. We also propose that Restorative Justice (RJ) is able to provide a preliminary ethical framework to deal with this common ethical oversight. Furthermore, we unite the RJ framework with that of Ward’s (2013) moral acquaintance model to provide a more powerful approach—RJ informed moral acquaintance—aimed at addressing the ethical challenges faced by practitioners within forensic and correctional roles

Tumor Suppressor Candidate 2 (TUSC2): Discovery, Functions, and Cancer Therapy

Tumor Suppressor Candidate 2 (TUSC2) was first discovered as a potential tumor suppressor gene residing in the frequently deleted 3p21.3 chromosomal region. Since its discovery, TUSC2 has been found to play vital roles in normal immune function, and TUSC2 loss is associated with the development of autoimmune diseases as well as impaired responses within the innate immune system. TUSC2 also plays a vital role in regulating normal cellular mitochondrial calcium movement and homeostasis. Moreover, TUSC2 serves as an important factor in premature aging. In addition to TUSC2\u27s normal cellular functions, TUSC2 has been studied as a tumor suppressor gene that is frequently deleted or lost in a multitude of cancers, including glioma, sarcoma, and cancers of the lung, breast, ovaries, and thyroid. TUSC2 is frequently lost in cancer due to somatic deletion within the 3p21.3 region, transcriptional inactivation via TUSC2 promoter methylation, post-transcriptional regulation via microRNAs, and post-translational regulation via polyubiquitination and proteasomal degradation. Additionally, restoration of TUSC2 expression promotes tumor suppression, eventuating in decreased cell proliferation, stemness, and tumor growth, as well as increased apoptosis. Consequently, TUSC2 gene therapy has been tested in patients with non-small cell lung cancer. This review will focus on the current understanding of TUSC2 functions in both normal and cancerous tissues, mechanisms of TUSC2 loss, TUSC2 cancer therapeutics, open questions, and future directions

A multi-layer extension of the stochastic heat equation

Motivated by recent developments on solvable directed polymer models, we define a 'multi-layer' extension of the stochastic heat equation involving non-intersecting Brownian motions.Comment: v4: substantially extended and revised versio

Hybridization Capture Using RAD Probes (hyRAD), a New Tool for Performing Genomic Analyses on Collection Specimens.

In the recent years, many protocols aimed at reproducibly sequencing reduced-genome subsets in non-model organisms have been published. Among them, RAD-sequencing is one of the most widely used. It relies on digesting DNA with specific restriction enzymes and performing size selection on the resulting fragments. Despite its acknowledged utility, this method is of limited use with degraded DNA samples, such as those isolated from museum specimens, as these samples are less likely to harbor fragments long enough to comprise two restriction sites making possible ligation of the adapter sequences (in the case of double-digest RAD) or performing size selection of the resulting fragments (in the case of single-digest RAD). Here, we address these limitations by presenting a novel method called hybridization RAD (hyRAD). In this approach, biotinylated RAD fragments, covering a random fraction of the genome, are used as baits for capturing homologous fragments from genomic shotgun sequencing libraries. This simple and cost-effective approach allows sequencing of orthologous loci even from highly degraded DNA samples, opening new avenues of research in the field of museum genomics. Not relying on the restriction site presence, it improves among-sample loci coverage. In a trial study, hyRAD allowed us to obtain a large set of orthologous loci from fresh and museum samples from a non-model butterfly species, with a high proportion of single nucleotide polymorphisms present in all eight analyzed specimens, including 58-year-old museum samples. The utility of the method was further validated using 49 museum and fresh samples of a Palearctic grasshopper species for which the spatial genetic structure was previously assessed using mtDNA amplicons. The application of the method is eventually discussed in a wider context. As it does not rely on the restriction site presence, it is therefore not sensitive to among-sample loci polymorphisms in the restriction sites that usually causes loci dropout. This should enable the application of hyRAD to analyses at broader evolutionary scales

Role of shelfbreak upwelling in the formation of a massive under-ice bloom in the Chukchi Sea

Author Posting. © The Author(s), 2014. This is the author's version of the work. It is posted here by permission of Elsevier for personal use, not for redistribution. The definitive version was published in Deep Sea Research Part II: Topical Studies in Oceanography 105 (2014): 17-29, doi:10.1016/j.dsr2.2014.03.017.In the summer of 2011, an oceanographic survey carried out by the Impacts of Climate on EcoSystems and Chemistry of the Arctic Pacific Environment (ICESCAPE) program revealed the presence of a massive phytoplankton bloom under the ice near the shelfbreak in the central Chukchi Sea. For most of the month preceding the measurements there were relatively strong easterly winds, providing upwelling favorable conditions along the shelfbreak. Analysis of similar hydrographic data from summer 2002, in which there were no persistent easterly winds, found no evidence of upwelling near the shelfbreak. A two-dimensional ocean circulation model is used to show that sufficiently strong winds can result not only in upwelling of high nutrient water from offshore onto the shelf, but it can also transport the water out of the bottom boundary layer into the surface Ekman layer at the shelf edge. The extent of upwelling is determined by the degree of overlap between the surface Ekman layer and the bottom boundary layer on the outer shelf. Once in the Ekman layer, this high nutrient water is further transported to the surface through mechanical mixing driven by the surface stress. Two model tracers, a nutrient tracer and a chlorophyll tracer, reveal distributions very similar to that observed in the data. These results suggest that the biomass maximum near the shelfbreak during the massive bloom in summer 2011 resulted from an enhanced supply of nutrients upwelled from the halocline seaward of the shelf. The decade long trend in summertime surface winds suggest that easterly winds in this region are increasing in strength and that such bloom events will become more common.This study was supported by the National Science Foundation under Grant OCE-0959381 (MAS), and by the Ocean Biology and Biogeochemistry Program and the Cryosphere Science Program of the National Aeronautic and Space Administration under Award NNX10AF42G (RSP;KRA). GWKM was supported by the Natural Sciences and Engineering Research Council of Canada. ETB was supported by the U. S. Navy