High temperature and humidity affect pollen viability and longevity in Olea europaea L.

Olea europaea L. is a crop typical of the Mediterranean area that has an important role in economy, society, and culture of this region. Climate change is expected to have significant impact on this crop, which is typically adapted to certain pedo-climatic characteristics of restricted geographic areas. In this scenario, the aim of this study was to evaluate the time-course response of pollen viability to different combinations of temperature and humidity. The study was performed comparing flowering time and pollen functionality of O. europaea from twelve cultivars growing at the same site belonging to the Campania olive collection in Italy. Pollen was incubated at 12◦C, 22◦C, and 36◦C in combination with 50% RH or 100% RH treatments for 5 days. The results highlighted that a drastic loss of pollen viability occurs when pollen is subjected to a combination of high humidity and high temperature, whereas 50% RH had less impact on pollen thermotolerance, because most cultivars preserved a high pollen viability over time. In the ongoing climate change scenario, it is critical to assess the effect of increasing temperatures on sensitive reproductive traits such as pollen viability to predict possible reduction in crop yield. Moreover, the results highlighted that the effect of temperature increase on pollen thermotolerance should be evaluated in combination with other environmental factors such as humidity conditions. The screening of olive cultivars based on pollen thermotolerance is critical in the ongoing climate change scenario, especially considering that the economic value of this species relies on successful fertilization and embryo development, and also that production cycle of Olea europaea can be longer than a hundred years

COVID-19 and the elderly: insights into pathogenesis and clinical decision-making

The elderly may represent a specific cluster of high-risk patients for developing COVID-19 with rapidly progressive clinical deterioration. Indeed, in older individuals, immunosenescence and comorbid disorders are more likely to promote viral-induced cytokine storm resulting in life-threatening respiratory failure and multisystemic involvement. Early diagnosis and individualized therapeutic management should be developed for elderly subjects based on personal medical history and polypharmacotherapy. Our review examines the pathogenesis and clinical implications of ageing in COVID-19 patients; finally, we discuss the evidence and controversies in the management in the long-stay residential care homes and aspects of end-of-life care for elderly patients with COVID-19

Constraining the vertical distribution of coastal dust aerosol using OCO-2 O₂ A-band measurements

Quantifying the vertical distribution of atmospheric aerosols is crucial for estimating their impact on the Earth's energy budget and climate, improving forecast of air pollution in cities, and reducing biases in the retrieval of greenhouse gases (GHGs) from space. However, to date, passive remote sensing measurements have provided limited information about aerosol extinction profiles. In this study, we propose the use of a spectral sorting approach to constrain the aerosol vertical structure using spectra of reflected sunlight absorption within the molecular oxygen (O₂) A-band collected by the Orbiting Carbon Observatory-2 (OCO-2). The effectiveness of the approach is evaluated using spectra acquired over the western Sahara coast by comparing the aerosol profile retrievals with lidar measurements from the Cloud-Aerosol Lidar and Infrared Pathfinder Satellite Observation (CALIPSO) Cloud-Aerosol Lidar with Orthogonal Polarization (CALIOP). Using a radiative transfer model to simulate OCO-2 measurements, we found that high-resolution O₂ A-band measurements have high sensitivity to aerosol optical depth (AOD) and aerosol layer height (ALH). Retrieved estimates of AOD and ALH based on a look up table technique show good agreement with CALIPSO measurements, with correlation coefficients of 0.65 and 0.53, respectively. The strength of the proposed spectral sorting technique lies in its ability to identify spectral channels with high sensitivity to AOD and ALH and extract the associated information from the observed radiance in a straightforward manner. The proposed approach has the potential to enable future passive remote sensing missions to map the aerosol vertical distribution on a global scale

Constraining the vertical distribution of coastal dust aerosol using OCO-2 O₂ A-band measurements

Quantifying the vertical distribution of atmospheric aerosols is crucial for estimating their impact on the Earth's energy budget and climate, improving forecast of air pollution in cities, and reducing biases in the retrieval of greenhouse gases (GHGs) from space. However, to date, passive remote sensing measurements have provided limited information about aerosol extinction profiles. In this study, we propose the use of a spectral sorting approach to constrain the aerosol vertical structure using spectra of reflected sunlight absorption within the molecular oxygen (O₂) A-band collected by the Orbiting Carbon Observatory-2 (OCO-2). The effectiveness of the approach is evaluated using spectra acquired over the western Sahara coast by comparing the aerosol profile retrievals with lidar measurements from the Cloud-Aerosol Lidar and Infrared Pathfinder Satellite Observation (CALIPSO) Cloud-Aerosol Lidar with Orthogonal Polarization (CALIOP). Using a radiative transfer model to simulate OCO-2 measurements, we found that high-resolution O₂ A-band measurements have high sensitivity to aerosol optical depth (AOD) and aerosol layer height (ALH). Retrieved estimates of AOD and ALH based on a look up table technique show good agreement with CALIPSO measurements, with correlation coefficients of 0.65 and 0.53, respectively. The strength of the proposed spectral sorting technique lies in its ability to identify spectral channels with high sensitivity to AOD and ALH and extract the associated information from the observed radiance in a straightforward manner. The proposed approach has the potential to enable future passive remote sensing missions to map the aerosol vertical distribution on a global scale

Aspiration therapy for the treatment of obesity: 4-year results of a multicenter randomized controlled trial.

BackgroundThe AspireAssist is the first Food and Drug Administration-approved endoluminal device indicated for treatment of class II and III obesity.ObjectivesWe earlier reported 1-year results of the PATHWAY study. Here, we report 4-year outcomes.SettingUnited States-based, 10-center, randomized controlled trial involving 171 participants with the treatment arm receiving Aspiration Therapy (AT) plus Lifestyle Therapy and the control arm receiving Lifestyle Therapy (2:1 randomization).MethodsAT participants were permitted to continue in the study for an additional year up to a maximum of 5 years providing they maintained at least 10% total weight loss (TWL) from baseline at each year end. For AT participants who continued the study, 5 medical monitoring visits were provided at weeks 60, 68, 76, 90, and 104 and thereafter once every 13 weeks up to week 260. Exclusion criteria were a history of eating disorder or evidence of eating disorder on a validated questionnaire. Follow-up weight, quality of life, and co-morbidities were compared with the baseline levels. In addition, rates of serious adverse event, persistent fistula, withdrawal, and A-tube replacement were reported. All analyses were performed using a per-protocol analysis.ResultsOf the 82 AT participants who completed 1 year, 58 continued to this phase of the trial. Mean baseline body mass index of these 58 patients was 41.6 ± 4.5 kg/m2. At the end of first year (at the beginning of the follow-up study), these 58 patients had a body mass index of 34.1 ± 5.4 kg/m2 and had achieved an 18.3 ± 8.0% TWL. On a per protocol basis, patients experienced 14.2%, 15.3%, 16.6%, and 18.7% TWL at 1, 2, 3, and 4 years, respectively (P < .01 for all). Forty of 58 patients (69%) achieved at least 10% TWL at 4 years or at time of study withdrawal. Improvements in quality of life scores and select cardiometabolic parameters were also maintained through 4 years. There were 2 serious adverse events reported in the second through fourth years, both of which resolved with removal or replacement of the A tube. Two persistent fistulas required surgical repair, representing approximately 2% of all tube removals. There were no clinically significant metabolic or electrolytes disorders observed, nor any evidence for development of any eating disorders.ConclusionsThe results of this midterm study have shown that AT is a safe, effective, and durable weight loss alternative for people with class II and III obesity and who are willing to commit to using the therapy and adhere to adjustments in eating behavior

Stay on track: A pilot randomized control trial on the feasibility of a diet and exercise intervention in patients with breast cancer receiving radiotherapy

PURPOSE: Among patients with breast cancer undergoing radiotherapy, posttreatment cardiovascular disease and worsened quality of life (QoL) are leading causes of morbidity and mortality. To overcome these negative radiotherapy effects, this prospective, randomized clinical trial pilots a 12-week Stay on Track exercise and diet intervention for overweight patients with nonmetastatic breast cancer undergoing whole-breast radiotherapy. EXPERIMENTAL DESIGN: The intervention group (n = 22) participated in three personal exercise and dietary counseling sessions, and received three text reminders/week to adhere to recommendations. The control group (n = 22) was administered a diet/exercise information binder. All patients received a Fitbit, and at baseline, 3 months, and 6 months, measurements of biomarkers, dual-energy X-ray absorptiometry scans, QoL and physical activity surveys, and food frequency questionnaires were obtained. A satisfaction survey was administered at 3 months. RESULTS: Stay on Track was well received, with high rates of adherence and satisfaction. The intervention group showed an increase in self-reported physical activity and preserved QoL, a decrease in body mass index and visceral fat, and higher American Cancer Society/American Institute of Cancer Research dietary adherence. The control participants had reduced QoL, anti-inflammatory markers, and increased metabolic syndrome markers. Both groups had decreased overall body mass. These changes were within group effects. When comparing the intervention and control groups over time, there were notable improvements in dietary adherence in the intervention group. CONCLUSIONS: Targeted lifestyle interventions during radiotherapy are feasible and could decrease cardiovascular comorbidities in patients with breast cancer. Larger-scale implementation with longer follow-up can better determine interventions that influence cardiometabolic health and QoL. SIGNIFICANCE: This pilot study examines cardiometabolic benefits of a combined diet and exercise intervention for patients with breast cancer undergoing radiotherapy. The intervention included an activity tracker (FitBit) and text message reminders to promote adherence to lifestyle interventions. Large-scale implementation of such programs may improve cardiometabolic outcomes and overall QoL among patients with breast cancer

Prevalencia de IACS en el HIGA San Roque de Gonnet : Otra medida de la calidad de atención

Las infecciones asociadas a los cuidados de la salud (IACS) son un grave problema de salud pública y uno de los indicadores de la calidad de la asistencia. Todos reconocemos que hoy es de vital importancia su vigilancia y prevención. En el HIGA San Roque de Gonnet se implementan dos herramientas para evaluar los índices de riesgo de IACS. Desde el 2005 el hospital realiza vigilancia continua en áreas críticas (UTIUCIN) y cirugías limpias de Traumatología y Neurocirugía. Desde el 2010 se incorpora al Estudio Nacional de Prevalencia de Infecciones Hospitalarias de Argentina (ENPIHA) que se realiza anualmente en el mes de agosto. Este instrumento de vigilancia permite proporcionar datos homogéneos y comparables para nuestra Institución. Son esperables según la bibliografía tasas entre 3 y 9 % ; los datos obtenidos en nuestra institución son imprescindibles para gestionar las actividades del Comité de Control de Infecciones y son una evidencia de la calidad de atención que se ofrece a nuestros pacientes.Facultad de Ciencias Médica

Sustained Weight Loss Following 12-Month Pramlintide Treatment as an Adjunct to Lifestyle Intervention in Obesity

OBJECTIVE—To assess long-term weight loss efficacy and safety of pramlintide used at different dosing regimens and in conjunction with lifestyle intervention (LSI)