Effect of colchicine injection prior to the initiating phase of two-stage skin carcinogenesis in mice.

Colchicine injected 5, 9 and 24 h respectively before initiation (using s.c. injection of urethane for initiating action and TPA skin applications for promoting action, in female ICR mice) led to a significant increase in skin tumour incidence in the --9-h group, and an increase in percentage malignancy in both the --5- and --9-h groups. These times corresponded to the peak of metaphase arrest by the colchicine. The results are discussed in relation in those of Pound and Withers (1963) and others, who found that mitotic stimulation at the time of urethane initiating action raised the ultimate tumour incidence; and the inference is drawn that initiating action in mouse skin may occur during the M phase, rather than during the G1, S, or G2 phases, as suggested by others

Structural analysis of the baroque parish church of Zsámbék

On the walls and vaults of the Roman Catholic Parish Church of Zsámbék cracks have long been observed. According to the parishioners, the crack widths have widened recently and new cracks have also appeared. This may have happened due to the increased traffic of the road beside the church. In this paper we report on the structural analysis, including the investigation of vibrations induced by the traffic in the structural elements. We found that the weakness of the structural system of that age results from uneven settlement of the foundations due to the soil strata and constructional errors from the previous restorations. As the result of our analysis we recommended possible solutions for restoring the structural integrity of the church building

Ribbed vaults of the Nagyvázsony monastery church - Geometrical factor of safety highlights the secret

Using the geometrical factor of safety, the article compares three ribbed vaults which are different in their structures and complexity. Each vault could have been built for the Nagyvázsony monastery church. The spatial geometry of the three different vaults is based on the rules of control curve construction using the known geometry of the remains of the church ruins. The thrust lines for the ribs are determined for the dead load of the vault in each case. These thrust lines, as statically possible solutions, prove the suitability of the structures, and the geometrical factor of safety of the ribs helps to specify the geometry based on which the vault could be built. The preliminary results of our research indicate that the geometrical factor of safety of the pointed groin vault proved to be the highest. From the three examined vaults, this one is the first that appeared in the history of architecture. Our conclusion is that the later built, more complex vaults raised not only geometrical or execution difficulties, but were also daring solutions from the aspect of the stability of the ribs

A kóros elmeállapot és az ittaság büntetőjogi értékelése a BTK-ban

INST: L_08

Leukaemogenic action of phorbol in intact and thymectomized mice of different strains.

Phorbol, the unesterified parent alcohol of the skin promoter TPA, was administered i.p., twice weekly, throughout the lifetime of mice of 7 inbred strains: males and females of AKR/J, C3Heb and BALB/c, and females of SJL/J, DBA/2, SWR and C57BL. A striking difference in strain response was observed, with a pronounced leukaemogenic effect in SWR, a signficiant shortening of the latent period for spontaneous reticulum cell sarcomas (RCNB) in SJL/J, and no demonstrable effect in the other strains. When mice of 3 of the above-mentioned strains (SWR, SJL/J and AKR/J) were thymectomized prior to the beginning of phorbol treatment, different patterns of response were again observed. Thymectomy did not influence the leukaemia incidence in SWR mice, slightly inhibited RCNB development in SJL/J mice and converted phorbol into a leukaemogenic agent for AKR/J mice