2,220 research outputs found
Homogenization of weakly coupled systems of Hamilton--Jacobi equations with fast switching rates
We consider homogenization for weakly coupled systems of Hamilton--Jacobi
equations with fast switching rates. The fast switching rate terms force the
solutions converge to the same limit, which is a solution of the effective
equation. We discover the appearance of the initial layers, which appear
naturally when we consider the systems with different initial data and analyze
them rigorously. In particular, we obtain matched asymptotic solutions of the
systems and rate of convergence. We also investigate properties of the
effective Hamiltonian of weakly coupled systems and show some examples which do
not appear in the context of single equations.Comment: final version, to appear in Arch. Ration. Mech. Ana
Tests of stellar model atmospheres by optical interferometry III: NPOI and VINCI interferometry of the M0 giant gamma Sge covering 0.5 - 2.2 microns
Aims: We present a comparison of the visual and NIR intensity profile of the
M0 giant gamma Sagittae to plane-parallel ATLAS 9 as well as to plane-parallel
& spherical PHOENIX model atmospheres. Methods: We use previously described
visual interferometric data obtained with the NPOI in July 2000. We apply the
recently developed technique of coherent integration, and thereby obtain
visibility data of more spectral channels and with higher precision than
before. In addition, we employ new measurements of the K-band diameter of gamma
Sagittae obtained with the instrument VINCI at the VLTI in 2002. Results: The
spherical PHOENIX model leads to a precise definition of the Rosseland angular
diameter and a consistent high-precision diameter value for our NPOI and
VLTI/VINCI data sets of Theta_Ross=6.06 pm 0.02 mas, with the Hipparcos
parallax corresponding to R_Ross=55 pm 4 R_sun, and with the bolometric flux
corresponding to an effective temperature T_eff=3805 pm 55 K. Our visual
visibility data close to the first minimum and in the second lobe constrain the
limb-darkening effect and are generally consistent with the model atmosphere
predictions. The visual closure phases exhibit a smooth transition between 0
and pi. Conclusions: The agreement between the NPOI and VINCI diameter values
increases the confidence in the model atmosphere predictions from optical to
NIR wavelengths as well as in the calibration and accuracy of both
interferometric facilities. The consistent night-by-night diameter values of
VINCI give additional confidence in the given uncertainties. The closure phases
suggest a slight deviation from circular symmetry, which may be due to surface
features, an asymmetric extended layer, or a faint unknown companion.Comment: 12 pages, 9 figures, accepted by A&A. Also available from
http://www.aanda.org/articles/aa/pdf/forth/aa5853_06.pd
Projections of the current and future disease burden of hepatitis C virus infection in Malaysia
The prevalence of hepatitis C virus (HCV) infection in Malaysia has been estimated at 2.5% of the adult population. Our objective, satisfying one of the directives of the WHO Framework for Global Action on Viral Hepatitis, was to forecast the HCV disease burden in Malaysia using modelling methods.An age-structured multi-state Markov model was developed to simulate the natural history of HCV infection. We tested three historical incidence scenarios that would give rise to the estimated prevalence in 2009, and calculated the incidence of cirrhosis, end-stage liver disease, and death, and disability-adjusted life-years (DALYs) under each scenario, to the year 2039. In the baseline scenario, current antiviral treatment levels were extended from 2014 to the end of the simulation period. To estimate the disease burden averted under current sustained virological response rates and treatment levels, the baseline scenario was compared to a counterfactual scenario in which no past or future treatment is assumed.In the baseline scenario, the projected disease burden for the year 2039 is 94,900 DALYs/year (95% credible interval (CrI): 77,100 to 124,500), with 2,002 (95% CrI: 1340 to 3040) and 540 (95% CrI: 251 to 1,030) individuals predicted to develop decompensated cirrhosis and hepatocellular carcinoma, respectively, in that year. Although current treatment practice is estimated to avert a cumulative total of 2,200 deaths from DC or HCC, a cumulative total of 63,900 HCV-related deaths is projected by 2039.The HCV-related disease burden is already high and is forecast to rise steeply over the coming decades under current levels of antiviral treatment. Increased governmental resources to improve HCV screening and treatment rates and to reduce transmission are essential to address the high projected HCV disease burden in Malaysia
Autologous graft-versus-host disease induction in advanced breast cancer: role of peripheral blood progenitor cells
The purpose of the present study was to investigate the impact of the use of peripheral blood progenitor cells (PBPCs) on the induction of autologous graft-versus-host disease (GVHD) in patients with advanced breast cancer. 14 women with stage IIIB and 36 women with stage IV breast cancer received cyclosporine (CsA) 2.5 mg kgâ1 i.v. daily, d 0â28, and interferon-gamma (IFNg) 0.025 mg/m2 s.c. qod, d7â28, following PBPC-T ± bone marrow transplantation (BMT). Preceding high-dose chemotherapy consisted of cyclophosphamide 6 g/m2 and thiotepa 800 mg/m2. Histologically proven â„grade II cutaneous GVHD was induced in18/50 (36%) of patients and was independent of the source of haematopoietic support. In vitro studies showed that post-transplant, 76% of patients had developed auto-cytotoxicity against their own pre-transplant PHA-lymphoblasts. A significant correlation between the occurrence of GVHD â„grade II and cytolysis was observed in the NK cell-line K562 and the T47D breast cancer cell-line. With a median follow-up of 2Âœ years, the overall survival (OS) is 58%, the disease-free survival (DFS) 26%, both independent of the development of GVHD and similar to what has been observed in other studies on high-dose chemotherapy in advanced breast cancer. It therefore remains unclear whether the induction of autologous GVHD with the occurrence of auto-cytotoxic lymphocytes can result in an anti-tumour effect in this group of patients. © 2000 Cancer Research Campaign http://www.bjcancer.co
Strange Quark Contributions to Parity-Violating Asymmetries in the Backward Angle G0 Electron Scattering Experiment
We have measured parity-violating asymmetries in elastic electron-proton and
quasi-elastic electron-deuteron scattering at Q^2 = 0.22 and 0.63 GeV^2. They
are sensitive to strange quark contributions to currents in the nucleon, and to
the nucleon axial current. The results indicate strange quark contributions of
< 10% of the charge and magnetic nucleon form factors at these four-momentum
transfers. We also present the first measurement of anapole moment effects in
the axial current at these four-momentum transfers.Comment: 5 pages, 2 figures, changed references, typo, and conten
Transverse Beam Spin Asymmetries in Forward-Angle Elastic Electron-Proton Scattering
We have measured the beam-normal single-spin asymmetry in elastic scattering
of transversely-polarized 3 GeV electrons from unpolarized protons at Q^2 =
0.15, 0.25 (GeV/c)^2. The results are inconsistent with calculations solely
using the elastic nucleon intermediate state, and generally agree with
calculations with significant inelastic hadronic intermediate state
contributions. A_n provides a direct probe of the imaginary component of the
2-gamma exchange amplitude, the complete description of which is important in
the interpretation of data from precision electron-scattering experiments.Comment: 5 pages, 3 figures, submitted to Physical Review Letters; shortened
to meet PRL length limit, clarified some text after referee's comment
Transverse Beam Spin Asymmetries at Backward Angles in Elastic Electron-Proton and Quasi-elastic Electron-Deuteron Scattering
We have measured the beam-normal single-spin asymmetries in elastic
scattering of transversely polarized electrons from the proton, and performed
the first measurement in quasi-elastic scattering on the deuteron, at backward
angles (lab scattering angle of 108 degrees) for Q2 = 0.22 GeV^2/c^2 and 0.63
GeV^2/c^2 at beam energies of 362 MeV and 687 MeV, respectively. The asymmetry
arises due to the imaginary part of the interference of the two-photon exchange
amplitude with that of single photon exchange. Results for the proton are
consistent with a model calculation which includes inelastic intermediate
hadronic (piN) states. An estimate of the beam-normal single-spin asymmetry for
the scattering from the neutron is made using a quasi-static deuterium
approximation, and is also in agreement with theory
Strange Quark Contributions to Parity-Violating Asymmetries in the Forward G0 Electron-Proton Scattering Experiment
We have measured parity-violating asymmetries in elastic electron-proton
scattering over the range of momentum transfers 0.12 < Q^2 < 1.0 GeV^2. These
asymmetries, arising from interference of the electromagnetic and neutral weak
interactions, are sensitive to strange quark contributions to the currents of
the proton. The measurements were made at JLab using a toroidal spectrometer to
detect the recoiling protons from a liquid hydrogen target. The results
indicate non-zero, Q^2 dependent, strange quark contributions and provide new
information beyond that obtained in previous experiments.Comment: 5 pages, 2 figure
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