The Mesoarchean Amikoq Layered Complex of SW Greenland: Part 2. Geochemical evidence for high-Mg noritic plutonism through crustal assimilation

Whole-rock major- A nd trace-element data are presented on a sample collection from the \u3e3 Ga Amikoq Layered Complex (ALC), and hosting amphibolites within the Mesoarchean Akia terrane, SW Greenland. The lithologies range from leuconorite to melanorite/feldspathic orthopyroxenite, orthopyroxenite to harzburgite through to dunite, and tholeiitic basaltic-picritic mafic host rocks. The Amikoq Layered Complex samples are primitive (Mg#: 65-89) with elevated Ni and Cr contents. However, the absence of troctolitic lithologies and the presence of two orthopyroxene compositional trends, suggests that the successions might not be comagmatic. On the basis of trace-element cumulate models, relatively low Ni contents and minor negative Sr-Eu anomalies in some high-Ti ultramafic rocks, it is not possible to exclude a petrogenesis related to a melt similar to that of the mafic host-rocks. Ultramafic samples with U-shaped trace-element distribution patterns are petrogenetically related to the noritic sequences, either through cumulus mineral accumulation or melt-rock reactions. Assimilation-fractional-crystallisation modelling of melanorites nevertheless require the parental melt to have been contaminated/mixed with a component of island-arc-like tholeiite affinity. A boninite-like parental melt might have been derived from the subcontinental lithospheric mantle of the Akia terrane, or alternatively via assimilation of an ultramafic parental melt with island-arc-like tholeiite. Given the complex geological evolution and high-grade metamorphic overprint of the Amikoq Layered Complex, we are unable to differentiate between the two models

Palaeoproterozoic foreland fold-thrust belt structures and lateral faults in the West Troms Basement Complex, northern Norway, and their relation to inverted metasedimentary sequences

Palaeoproterozoic fold-thrust belt structures and steep, lateral shear zones characterize the foreland deformation of Neoarchaean basement tonalites in Vanna, West Troms Basement Complex, northern Norway. Low-grade par-autochthonous and allochthonous cover units (2.4–2.2. Ga) with sandstones and calcareous metapelites exist in separate areas of the foreland. They were formed as intracontinental rift- and/or deltaic shelf deposits, and subsequently intruded by a diorite sill at c. 2.2 Ga. The basement and cover units were folded and inverted along low-angle thrusts and steep reverse faults during two late/post Svecofennian (1.77–1.63 Ga) orthogonal shortening events (D1-D2). The D1 event involved NE-SW shortening, folding, ENE-directed thrusting, and dextral lateral shearing, controlled by pre-existing, N-S striking mafic dykes (c. 2.4 Ga) and basin-bounding normal faults. The D2 event involved SE vergent nappe translation, flat-ramp thrust propagation in a frontal duplex above a basement-seated detachment, and sinistral lateral reactivation in a partitioned orogen-parallel, transpressive setting. Hydrothermal fluid circulation affected all the shear zones. New aeromagnetic data show the basement-involved fold-thrust belt architecture well. The orthogonal Vanna Island fold-thrust belt styles of deformation resemble other inverted rift-basin deposits in northern Fennoscandia, deformed during the Svecofennian Orogeny (1.92–1.79 Ga), Alta-Kautokeino and Karasjok greenstone belts in northern Norway, Central Lapland, Peräpohja, Kittilä and Kuusamo belts of Finland, and in the Norrbotten province of Sweden. Westward younging of the orogenic events explain the younger age span of deformation on Vanna Islan

Large expert-curated database for benchmarking document similarity detection in biomedical literature search

Document recommendation systems for locating relevant literature have mostly relied on methods developed a decade ago. This is largely due to the lack of a large offline gold-standard benchmark of relevant documents that cover a variety of research fields such that newly developed literature search techniques can be compared, improved and translated into practice. To overcome this bottleneck, we have established the RElevant LIterature SearcH consortium consisting of more than 1500 scientists from 84 countries, who have collectively annotated the relevance of over 180 000 PubMed-listed articles with regard to their respective seed (input) article/s. The majority of annotations were contributed by highly experienced, original authors of the seed articles. The collected data cover 76% of all unique PubMed Medical Subject Headings descriptors. No systematic biases were observed across different experience levels, research fields or time spent on annotations. More importantly, annotations of the same document pairs contributed by different scientists were highly concordant. We further show that the three representative baseline methods used to generate recommended articles for evaluation (Okapi Best Matching 25, Term Frequency-Inverse Document Frequency and PubMed Related Articles) had similar overall performances. Additionally, we found that these methods each tend to produce distinct collections of recommended articles, suggesting that a hybrid method may be required to completely capture all relevant articles. The established database server located at https://relishdb.ict.griffith.edu.au is freely available for the downloading of annotation data and the blind testing of new methods. We expect that this benchmark will be useful for stimulating the development of new powerful techniques for title and title/abstract-based search engines for relevant articles in biomedical science. © The Author(s) 2019. Published by Oxford University Press

Safety and efficacy of non-steroidal anti-inflammatory drugs to reduce ileus after colorectal surgery

Background: Ileus is common after elective colorectal surgery, and is associated with increased adverse events and prolonged hospital stay. The aim was to assess the role of non-steroidal anti-inflammatory drugs (NSAIDs) for reducing ileus after surgery. Methods: A prospective multicentre cohort study was delivered by an international, student- and trainee-led collaborative group. Adult patients undergoing elective colorectal resection between January and April 2018 were included. The primary outcome was time to gastrointestinal recovery, measured using a composite measure of bowel function and tolerance to oral intake. The impact of NSAIDs was explored using Cox regression analyses, including the results of a centre-specific survey of compliance to enhanced recovery principles. Secondary safety outcomes included anastomotic leak rate and acute kidney injury. Results: A total of 4164 patients were included, with a median age of 68 (i.q.r. 57\u201375) years (54\ub79 per cent men). Some 1153 (27\ub77 per cent) received NSAIDs on postoperative days 1\u20133, of whom 1061 (92\ub70 per cent) received non-selective cyclo-oxygenase inhibitors. After adjustment for baseline differences, the mean time to gastrointestinal recovery did not differ significantly between patients who received NSAIDs and those who did not (4\ub76 versus 4\ub78 days; hazard ratio 1\ub704, 95 per cent c.i. 0\ub796 to 1\ub712; P = 0\ub7360). There were no significant differences in anastomotic leak rate (5\ub74 versus 4\ub76 per cent; P = 0\ub7349) or acute kidney injury (14\ub73 versus 13\ub78 per cent; P = 0\ub7666) between the groups. Significantly fewer patients receiving NSAIDs required strong opioid analgesia (35\ub73 versus 56\ub77 per cent; P < 0\ub7001). Conclusion: NSAIDs did not reduce the time for gastrointestinal recovery after colorectal surgery, but they were safe and associated with reduced postoperative opioid requirement