The Chesapeake Bay: A Study of Present and Furture Water Quality and Its Ecological Effects Volume I: Analysis and Projection of Water Quality

This study, prepared for the National Commission on Water Quality, is an analysis of the present and future water quality in the Chesapeake Bay from the Susquehanna River at Conowingo, Md. to the Atlantic Ocean. The objectives addressed in this volume of the study are 1.) Description of the present conditions of water quality and water quantity with respect to temperature, salinity, nutrients and dissolved oxygen. and 2.) Projection of future water quality conditions associated with the achievement of require ments and goals of the Federal Water Pollution Control Act Amendments of 1972, P.L. 92-500, 86 Stat. 816. The assessment of present and future biological and ecol ogical conditions is addressed in Volume II

Prepared by

NOTICE This technical report does not necessarily represent final EPA decisions or positions. It is intended to present technical analysis of issues using data which are currently available. The purpose in the release of such reports is to facilitate the exchange of technical information and to inform the public of technical developments which may form the basis for a final EPA decision, position, or regulatory action

Phase II evaluation of dibromodulcitol, ICRF-159, and maytansine for sarcomas

Patients with objectively measurable soft tissue sarcomas, osteosarcomas, chondrosarcomas, and mesotheliomas were treated with dibromodulcitol (DBD) (180 mg/m2 p.o. days 1-10 q4 wks.). ICRF-159 (300 mg/m2 p.o. tid days 1-3 q4 wks), or maytansine (MAYT) (1.5 mg/m2 I.V. q3 wks.). Forty-five evaluable patients received DBD, 47 MAYT, and 37 ICRF-159. Only patients who had had their histopathologic diagnoses confirmed by a pathology reference panel were included in the final analysis. Two patients had objective partial responses: a patient with osteosarcoma who responded to DBD and a patient with fibrosarcoma who had a partial response of brief duration to ICRF-159. Approximately 70% of the patients treated with each drug were of ECOG performance status 0 or 1, and over half had moderate or worse toxicity. It seems unlikely that these drugs have significant therapeutic activity for common mesenchymal malignancies

Economic gains of improving soil fertility and water holding capacity with clay application: the impact of soil remediation research in northeast Thailand

Soil improvement / Impact assessment / Research projects / Soil fertility / Sandy soils / Water holding capacity / Clay soils / Soil water relations / Soil management / Farming systems / Crop yield / Vegetable crops / Rice / Sorghum / Models / Statistical methods / Cost benefit analysis / Economic analysis / Economic aspects / Thailand