Association of Lipidome Remodeling in the Adipocyte Membrane with Acquired Obesity in Humans

The authors describe a new approach to studying cellular lipid profiles and propose a compensatory mechanism that may help maintain the normal membrane function of adipocytes in the context of obesity

Application of The New Shape Crushing Plate in Machine Crushing Processes

The results of studies of the crushing process in a double toggle jaw crusher are presented. This process was carried out on six sets of crushing plates. The first three of them are used in industrial crushers – plates with a flat working surface and a triangular profile (in this work, under consideration were profiles with teeth angle γ = 90°). The fourth and fifth type refer to plates with a variable pitch t and teeth height with a triangular shape of the teeth. In the sixth solution, plates with variable pitch and width of the wedged teeth are proposed

Application of The New Shape Crushing Plate in Machine Crushing Processes

The results of studies of the crushing process in a double toggle jaw crusher are presented. This process was carried out on six sets of crushing plates. The first three of them are used in industrial crushers – plates with a flat working surface and a triangular profile (in this work, under consideration were profiles with teeth angle γ = 90°). The fourth and fifth type refer to plates with a variable pitch t and teeth height with a triangular shape of the teeth. In the sixth solution, plates with variable pitch and width of the wedged teeth are proposed. The results of the basic process parameters are shown, that is, average degree of fineness n, technical performance Wt, crushing energy L and crushing force F, sieve analysis of crushing product. The obtained results are the basis for the assessment of the suitability of various types of plates, especially plates with a new profile, which have an altered shape in comparison with the plates used in crushers so far. The crushing tests were carried out with the same dimension of outlet slot er = 24 mm, close to the pitch size for plates with triangular profile. Tests were performed on the "Mucharz" sandstone. Samples from a series of blocks of different size and geometric shape were prepared. This work also presents feed mass influence on crushing process efficiency. The plates with variable pitch and width of teeth are beneficial because of lower crushing force and energy

History and operation of the Polish Fireball Network

The Polish Fireball Network (PFN) is a project to monitor regularly the sky over Poland in order to detect bright fireballs. In 2016 the 72 PFN cameras recorded 100 389 meteor events. Using these data and the UFOOrbit software 19 087 trajectories and orbits were calculated. In the following years we are planning intensive modernization of the PFN network including installation of dozens of new digital cameras.Polish Fireball Network (PFN) to projekt polegający na regularnym monitorowaniu nieba nad Polską w celu zaobserwowania jasnych meteorów i bolidów. W 2016 roku 72 kamery PFN zarejestrowały 100 389 meteorów. Za pomocą tych danych i oprogramowania UFOOrbit obliczono 19 087 trajektorie i orbity. W kolejnych latach planujemy intensywną modernizację sieci PFN, w tym instalację kilkudziesięciu nowych kamer cyfrowych

Refined OPLS All-Atom Force Field for Saturated Phosphatidylcholine Bilayers at Full Hydration

We report parametrization of dipalmitoyl-phosphatidylcholine (DPPC) in the framework of the Optimized Parameters for Liquid Simulations all-atom (OPLS-AA) force field. We chose DPPC as it is one of the most studied phospholipid species and thus has plenty of experimental data necessary for model validation, and it is also one of the highly important and abundant lipid types, e.g., in lung surfactant. Overall, PCs have not been previously parametrized in the OPLS-AA force field; thus, there is a need to derive its bonding and nonbonding parameters for both the polar and nonpolar parts of the molecule. In the present study, we determined the parameters for torsion angles in the phosphatidylcholine and glycerol moieties and in the acyl chains, as well the partial atomic charges. In these calculations, we used three methods: (1) Hartree–Fock (HF), (2) second order Møller–Plesset perturbation theory (MP2), and (3) density functional theory (DFT). We also tested the effect of the polar environment by using the polarizable continuum model (PCM), and for acyl chains the van der Waals parameters were also adjusted. In effect, six parameter sets were generated and tested on a DPPC bilayer. Out of these six sets, only one was found to be able to satisfactorily reproduce experimental data for the lipid bilayer. The successful DPPC model was obtained from MP2 calculations in an implicit polar environment (PCM)

Refined OPLS All-Atom Force Field for Saturated Phosphatidylcholine Bilayers at Full Hydration

We report parametrization of dipalmitoyl-phosphatidylcholine (DPPC) in the framework of the Optimized Parameters for Liquid Simulations all-atom (OPLS-AA) force field. We chose DPPC as it is one of the most studied phospholipid species and thus has plenty of experimental data necessary for model validation, and it is also one of the highly important and abundant lipid types, e.g., in lung surfactant. Overall, PCs have not been previously parametrized in the OPLS-AA force field; thus, there is a need to derive its bonding and nonbonding parameters for both the polar and nonpolar parts of the molecule. In the present study, we determined the parameters for torsion angles in the phosphatidylcholine and glycerol moieties and in the acyl chains, as well the partial atomic charges. In these calculations, we used three methods: (1) Hartree–Fock (HF), (2) second order Møller–Plesset perturbation theory (MP2), and (3) density functional theory (DFT). We also tested the effect of the polar environment by using the polarizable continuum model (PCM), and for acyl chains the van der Waals parameters were also adjusted. In effect, six parameter sets were generated and tested on a DPPC bilayer. Out of these six sets, only one was found to be able to satisfactorily reproduce experimental data for the lipid bilayer. The successful DPPC model was obtained from MP2 calculations in an implicit polar environment (PCM)

Increased Aluminum Content in Certain Brain Structures is Correlated with Higher Silicon Concentration in Alcoholic Use Disorder

Introduction: Alcohol overuse may be related to increased aluminum (Al) exposure, the brain accumulation of which contributes to dementia. However, some reports indicate that silicon (Si) may have a protective role over Al-induced toxicity. Still, no study has ever explored the brain content of Al and Si in alcoholic use disorder (AUD). Materials and methods: To fill this gap, the present study employed inductively coupled plasma optical emission spectrometry to investigate levels of Al and Si in 10 brain regions and in the liver of AUD patients (n = 31) and control (n = 32) post-mortem. Results: Al content was detected only in AUD patients at mean ± SD total brain content of 1.59 ± 1.19 mg/kg, with the highest levels in the thalamus (4.05 ± 12.7 mg/kg, FTH), inferior longitudinal fasciculus (3.48 ± 9.67 mg/kg, ILF), insula (2.41 ± 4.10 mg/kg) and superior longitudinal fasciculus (1.08 ± 2.30 mg/kg). Si content displayed no difference between AUD and control, except for FTH. Positive inter-region correlations between the content of both elements were identified in the cingulate cortex, hippocampus, and ILF. Conclusions: The findings of this study suggest that AUD patients may potentially be prone to Al-induced neurodegeneration in their brain—although this hypothesis requires further exploration