Propuesta en Supply Chain Management y Logística en la empresa IQA S.A.S

El presente trabajo se enfoca en una propuesta de mejora de la cadena de suministro en la empresa IQA S.A.S, la cual tiene como principal actividad la comercialización y distribución de suministros químicos alimentarios para medianas y pequeñas empresas del departamento de Sucre. La investigación se desarrolló por medio de diferentes fases, permitiendo inicialmente dar una contextualización general de la empresa para luego profundizar haciendo un diagnóstico de todos los subprocesos que integran a la cadena de suministro de IQA S.A.S, señalando las necesidades y oportunidades de mejora que se podrían implementar en la empresa. Es de esta manera como se van ejecutando gradualmente por cada fase diferentes planes de mejora, principalmente en los procesos de aprovisionamiento; donde por medio de una lista de chequeo se da a conocer la mejor forma de realizar los pedidos sin permitir desabastecimiento y realizar un correcto pronóstico de demanda. Por otra parte, se realizó una mejora significativa en los procesos de almacenamiento diseñando un nuevo layout que permitirá mejores rendimientos en el flujo y almacenamiento de los productos. Con esta propuesta se desea finalmente obtener unos resultados satisfactorios en los procesos logísticos de la empresa la cual continuara con sus actividades de una manera más organizada y productiva, apuntando siempre a una mejora continua permanente. Palabras clave: abastecimiento, demanda, empresa, proveedores, clientesThis work focuses on a proposal to improve the supply chain in the company IQA S.A.S, whose main activity is the commercialization and distribution of food chemical supplies for medium and small companies in the department of Sucre The research was developed through different phases, initially allowing to give a general contextualization of the company and then to deepen by making a diagnosis of all the sub-processes that make up the IQA SAS supply chain, pointing out the needs and opportunities for improvement that could be implement in the company. It is in this way that different improvement plans are gradually implemented in each phase, mainly in the supply processes; where by means of a checklist, the best way to place orders is disclosed without allowing shortages and making a correct demand forecast. On the other hand, a significant improvement was made in the storage processes by designing a new layout that will allow better performance in the flow and storage of the products. With this proposal it is finally desired to obtain satisfactory results in the logistical processes of the company which will continue with its activities in a more organized and productive way, always aiming at a permanent continuous improvement. Keywords: supply, demand, company, suppliers, customer

Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)

In 2008, we published the first set of guidelines for standardizing research in autophagy. Since then, this topic has received increasing attention, and many scientists have entered the field. Our knowledge base and relevant new technologies have also been expanding. Thus, it is important to formulate on a regular basis updated guidelines for monitoring autophagy in different organisms. Despite numerous reviews, there continues to be confusion regarding acceptable methods to evaluate autophagy, especially in multicellular eukaryotes. Here, we present a set of guidelines for investigators to select and interpret methods to examine autophagy and related processes, and for reviewers to provide realistic and reasonable critiques of reports that are focused on these processes. These guidelines are not meant to be a dogmatic set of rules, because the appropriateness of any assay largely depends on the question being asked and the system being used. Moreover, no individual assay is perfect for every situation, calling for the use of multiple techniques to properly monitor autophagy in each experimental setting. Finally, several core components of the autophagy machinery have been implicated in distinct autophagic processes (canonical and noncanonical autophagy), implying that genetic approaches to block autophagy should rely on targeting two or more autophagy-related genes that ideally participate in distinct steps of the pathway. Along similar lines, because multiple proteins involved in autophagy also regulate other cellular pathways including apoptosis, not all of them can be used as a specific marker for bona fide autophagic responses. Here, we critically discuss current methods of assessing autophagy and the information they can, or cannot, provide. Our ultimate goal is to encourage intellectual and technical innovation in the field