Karakteristik Plasma Lucutan Berpenghalang Dielektrik Isian Gas Nitrogen

Research on the characteristics of the dielectric barrier discharge filled with Nitrogen gas fields has been done. The plasma reactor that used in this study formed by a spiral-shaped cylindrical electrode component. Spiral electrode is made of copper wire with 72 windings and 25.05 mm of diameter, while the cylindrical electrode from copper sheets are glued on the walls of the outer tube diameter of 0,27 mm with a length of 25 cm. The dielectrics that used is pyrex with a length of 30 cm, a diameter of 3 cm, and a thickness of 2,45 mm. Characterization of dielectric barrier discharge plasma is used to determine the working area of the reactor and knowing the initial voltage to the emergence of the current as a sign of discharge. This characterization was done with Nitrogen gas field, which is a variation of voltage used is from 0,4 to 1.2 kV with a rise of 0.2 kV interval and Nitrogen flow rate of 2-8 L /min with intervals increase of 1 L/min. Result in the discharge flow 7 L/min with the lowest mobility value of 58.300 m2/V.s and the discharge flow 4 L/min with the highest mobility value of 91.600 m2/V.s. Therefore, it can be concluded that the greater the saturation current value, the greater the value of the ion mobility (μ)

Comparison of 192Os(p,n)192Ir and 192Os(d,2n)192Ir Nuclear Reactions for 192Ir Production

Iridium-192 (192Ir ) is a radionuclide currently suggested for brachyteraphy. One of the methods employed to produce high purity 192Ir is by irradiation of Osmium-192  (192Os) target using cyclotron. The success of 192Ir radionuclide production in cyclotrons requires deep understanding of irradiation parameters, including particle energy, target preparation and thickness, particle beam curent and irradiation time. Therefore, theoretical calculations of the 192Ir radioactivity yields should be carried out as a preliminary measure for more efficient 192Ir production. In this study, 192Ir production was simulated using the SRIM 2013 program to determine the optimum target thickness while the nuclearcross-section data were extracted from TENDL 2017. Two nuclear reactions for 192Ir production yield calculations were compared, i.e., 192Os(p,n)192Ir  and 192Os(d,2n)192Ir. The radioactivity yields for 192Os(p,n)192Ir nuclear reaction was found to be lower than  192Os(d,2n)192Ir reaction. For proton and deuteron energy of 30 MeV, the maximum radioactivity yield was 6.79 GBq for 192Os(p,n)192Ir and  26.14 GBq for 192Os(d,2n)192Ir. Several radionuclide impurities such as 191mIr, 190Ir, 191Os and 189Re were predicted to be generated during 192Os(p,n)192Ir reaction for proton incident energy between 1 and 30 MeV; meanwhile, 192Ir, 191mIr, 193Os, 193mIr, 192mOs and 191Os radionuclides were expected to contaminate during 192Os(d,2n)192Ir reaction for deuteron energy between 1 and 30 MeV. Results of this study can be used as a reference for future 192Ir radionuclide production when proton or deuteron beams are considered to be employed

Identifikasi Polisiklik Aromatik Hidrokarbon (PAH) dalam Emisi Kendaraan Bermotor dengan Menggunakan Whatman Filter Paper PM 2.5

Penelitian ini bertujuan untuk mengidentifikasi Polisiklik Aromatik Hidrokarbon (PAH) dalam Particulate Matter 2.5 µm (PM 2.5) yang diemisikan oleh beberapa sepeda motor. Emisi ditangkap dengan menggunakan Whatman Filter Paper PM 2.5. Senyawa PAH diisolasi dengan menggunakan metode ekstraksi soxhlet.. Analisis dilakukan dengan menggunakan instrumen Gas Chromatography Mass Spectrophotometer (GC/MS). Setelah dilakukan analisis dengan instrumen GC/MS terdapat beberapa senyawa PAH yang terdeteksi. Dari beberapa senyawa yang terdeteksi terdapa 4 senyawa PAH yang memiliki konsentrasi yang cukup tinggi, antara lain 1-naphthalen-2yl-ethanone, c-(3-vivyl-naphthalen-2-yl)-methylamine, 3-methyl-1,2,3,4-tetrahydro-anthracen-2-ylamine, dan 9-vinyl-naphthacene-2-carbonitrile

Pharmacogenomic associations of adverse drug reactions in asthma:systematic review and research prioritisation

We would like to thank the NIHR Collaboration for Leadership in Applied Health Research and Care North West Coast (CLAHRC) for funding Amanda McKenna’s internship, and Charlotte Kings MPhil, and the members of the PiCA consortia for their help in completing the survey. U. Potočnik, K. Repnik and V. Berce were supported by SysPharmPedia grant, co-financed by Ministry of Education, Science and Sport of the Republic of Slovenia Author information These authors contributed equally: Charlotte King, Amanda McKenna These authors jointly supervised this work: Ian Sinha, Daniel B. HawcuttPeer reviewedPublisher PD

Technical aspects and clinical limitations of sperm DNA fragmentation testing in male infertility: a global survey, current guidelines, and expert recommendations.

PURPOSE: Sperm DNA fragmentation (SDF) is a functional sperm abnormality that can impact reproductive potential, for which four assays have been described in the recently published sixth edition of the WHO laboratory manual for the examination and processing of human semen. The purpose of this study was to examine the global practices related to the use of SDF assays and investigate the barriers and limitations that clinicians face in incorporating these tests into their practice. MATERIALS AND METHODS: Clinicians managing male infertility were invited to complete an online survey on practices related to SDF diagnostic and treatment approaches. Their responses related to the technical aspects of SDF testing, current professional society guidelines, and the literature were used to generate expert recommendations via the Delphi method. Finally, challenges related to SDF that the clinicians encounter in their daily practice were captured. RESULTS: The survey was completed by 436 reproductive clinicians. Overall, terminal deoxynucleotidyl transferase deoxyuridine triphosphate Nick-End Labeling (TUNEL) is the most commonly used assay chosen by 28.6%, followed by the sperm chromatin structure assay (24.1%), and the sperm chromatin dispersion (19.1%). The choice of the assay was largely influenced by availability (70% of respondents). A threshold of 30% was the most selected cut-off value for elevated SDF by 33.7% of clinicians. Of respondents, 53.6% recommend SDF testing after 3 to 5 days of abstinence. Although 75.3% believe SDF testing can provide an explanation for many unknown causes of infertility, the main limiting factors selected by respondents are a lack of professional society guideline recommendations (62.7%) and an absence of globally accepted references for SDF interpretation (50.3%). CONCLUSIONS: This study represents the largest global survey on the technical aspects of SDF testing as well as the barriers encountered by clinicians. Unified global recommendations regarding clinician implementation and standard laboratory interpretation of SDF testing are crucial

Pharmacogenomic associations of adverse drug reactions in asthma: systematic review and research prioritisation

A systematic review of pharmacogenomic studies capturing adverse drug reactions (ADRs) related to asthma medications was undertaken, and a survey of Pharmacogenomics in Childhood Asthma (PiCA) consortia members was conducted. Studies were eligible if genetic polymorphisms were compared with suspected ADR(s) in a patient with asthma, as either a primary or secondary outcome. Five studies met the inclusion criteria. The ADRs and polymorphisms identified were change in lung function tests (rs1042713), adrenal suppression (rs591118), and decreased bone mineral density (rs6461639) and accretion (rs9896933, rs2074439). Two of these polymorphisms were replicated within the paper, but none had external replication. Priorities from PiCA consortia members (representing 15 institution in eight countries) for future studies were tachycardia (SABA/LABA), adrenal suppression/crisis and growth suppression (corticosteroids), sleep/behaviour disturbances (leukotriene receptor antagonists), and nausea and vomiting (theophylline). Future pharmacogenomic studies in asthma should collect relevant ADR data as well as markers of efficacy