Resource Management in Wireless Networks

A local call admission control (CAC) algorithm for third generation wireless networks was designed and implemented, which allows for the simulation of network throughput for different spreading factors and various mobility scenarios. A global CAC algorithm is also implemented and used as a benchmark since it is inherently optimized; it yields the best possible performance but has an intensive computational complexity. Optimized local CAC algorithm achieves similar performance as global CAC algorithm at a fraction of the computational cost. Design of a dynamic channel assignment algorithm for IEEE 802.11 wireless systems is also presented. Channels are assigned dynamically depending on the minimal interference generated by the neighboring access points on a reference access point. Analysis of dynamic channel assignment algorithm shows an improvement by a factor of 4 over the default settings of having all access points use the same channel, resulting significantly higher network throughput

Simulation of Throughput in UMTS Networks with Different Spreading Factors

In this paper, the authors design and implement a local session admission control (SAC) algorithm for third-generation wireless networks which allows for the simulation of network throughput for different spreading factors and various mobility scenarios

Drying Kinetics and Modelling of Mass Transfer in Thin Layer Convective Drying of Pineapple

The aim of the investigation was to study the drying characteristics of pineapple at different temperatures of 55, 60, 65, 70 and 75°C with 1.5 m/ s constant air velocity. In the present study, the best drying model was selected to describe the drying behaviour, and to develop the moisture profile using COMSOL. Based on the best criteria, Verma et al. was chosen as the best fit to the experimental data. The predicted moisture ratio values obtained from COMSOL simulation and Verma et al. were good agreement with the experimental data

The association of anti-platelet factor 4/heparin antibodies with early and delayed thromboembolism after cardiac surgery

Heparin induced thrombocytopenia (HIT) is a prothrombotic response to heparin therapy with platelet activating, anti-PF4/heparin antibodies leading to thrombocytopenia associated with thromboembolism

Biphasic organic synthesis with continuous electro-flow

Organic electrochemistry has recently witnessed a renaissance in research as a green and cost-efficient method for activating small molecules. Although some of the critical challenges of batch electrosynthesis remain, flow electrosynthesis can overcome several issues arising from batch electroorganic systems, such as mass transfer, ohmic drop, and selectivity. The combination of flow technology with electrochemistry affords practitioners a very precise control over reaction conditions, thereby enhancing the reproducibility of electrochemical processes. The use of gases in chemical reactions for the synthesis of value-added fine chemicals is of great significance. This review summarizes recent advances in flow electrochemistry for biphasic (gas–liquid) organic synthesis. We summarise recent examples of selective hydrocarbon oxidations using oxygen gas in an electrochemical flow reactor

Electrocatalytic continuous flow chlorinations with iodine(I/III) mediators

Electrochemistry offers tunable, cost effective and environmentally friendly alternatives to carry out redox reactions with electrons as traceless reagents. The use of organoiodine compounds as electrocatalysts is largely underdeveloped, despite their widespread application as powerful and versatile reagents. Mechanistic data reveal that the hexafluoroisopropanol assisted iodoarene oxidation is followed by a stepwise chloride ligand exchange for the catalytic generation of the dichloroiodoarene mediator. Here, we report an environmentally benign iodine(I/III) electrocatalytic platform for the in situ generation of dichloroiodoarenes for different reactions such as mono- and dichlorinations as well as chlorocyclisations within a continuous flow setup

Developing Antidote Controlled Antiplatelet Therapies By Targeting The Vwf ‐ Gp Ib‐Ix‐V Interaction

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/106054/1/jth02400.pd

Antidote-Controlled Platelet Inhibition Targeting von Willebrand Factor with Aptamers

Thrombus formation is initiated by platelets and leads to cardiovascular, cerebrovascular, and peripheral vascular disease, the leading causes of morbidity and mortality in the Western world. A number of antiplatelet drugs have improved clinical outcomes for thrombosis patients. However, their expanded use, especially in surgery, is limited by hemorrhage. Here, we describe an antiplatelet agent that can have its activity controlled by a matched antidote. We demonstrate that an RNA aptamer targeting von Willebrand factor (VWF) can potently inhibit VWF-mediated platelet adhesion and aggregation. By targeting this important adhesion step, we show that the aptamer molecule can inhibit platelet aggregation in PFA-100 and ristocetin-induced platelet aggregation assays. Furthermore, we show that a rationally designed antidote molecule can reverse the effects of the aptamer molecule, restoring platelet function quickly and effectively over a clinically relevant period. This aptamer-antidote pair represents a reversible antiplatelet agent inhibiting a platelet specific pathway. Furthermore, it is an important step towards creating safer drugs in clinics through the utilization of an antidote molecule.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/63204/1/oli.2007.0089.pd

Visible light-mediated photocatalytic oxidative cleavage of activated alkynes via hydroamination: a direct approach to oxamates

The direct oxidative cleavage of activated alkynes via hydroamination has been described using organic photocatalyst under visible-light irradiation at room temperature. In this reaction, the single electron oxidation of an in situ formed enamine followed by radical coupling with an oxidant finally delivers the oxamate. The key features of this photocatalytic reaction are the mild reaction conditions, metal-free organic dye as a photocatalyst, and TBHP playing a dual role as "O" source and for the regeneration of the photocatalyst. This journal is © The Royal Society of Chemistry

Evaluation of MR/fluoroscopy-guided portosystemic shunt creation in a swine model

PURPOSE: To evaluate three different percutaneous portosystemic shunts created with magnetic resonance (MR) imaging and fluoroscopy guidance in a swine model. MATERIALS AND METHODS: In stage 1 of the experiment, an active MR intravascular needle system was created for needle tracking and extracaval punctures. Twenty inferior vena cava (IVC)/superior mesenteric vein (SMV)/portal vein (PV) punctures were performed in 10 swine (weight, 40-45 kg) in a 1.5-T short-bore interventional MR imager. With use of a real-time MR imaging sequence, the needle was guided through the IVC and into the SMV or PV (N = 20 punctures). After confirmation, a wire was advanced into the portal venous system under MR imaging guidance (N = 20). In stage 2, animals were transferred to the radiographic fluoroscopy suite for deployment of shunts. Three different shunts were evaluated in this study: (i) a commercial stent-graft, (ii) a prototype bridging stent, and (iii) a prototype nitinol vascular anastomotic device. Postprocedural necropsy was performed in all animals. RESULTS: Successful MR-guided IVC/SMV punctures were performed in all 20 procedures (100%). All three shunts were deployed. Stent-grafts had the poorest mechanism for securing a shunt. The vascular anastomotic device and the bridging stent had more secure anchoring mechanisms but also had higher technical failure rates (50% and 40%, respectively). When deployed successfully, the vascular anastomotic device resulted in no bleeding at the sites of punctures at necropsy. CONCLUSION: Percutaneous shunts and vascular anastomoses between the portal mesenteric venous system and IVC were successfully created with use of a combination of MR imaging and conventional fluoroscopy for guidance. © SIR, 2006