1,923 research outputs found
Human security and the rise of the social
As the concept of human security has become part of the mainstream discourse of international politics it should be no surprise that both realist and critical approaches to international theory have found the agenda wanting. This article seeks to go beyond both the realist and biopolitical critiques by situating all three â political realism, biopolitics and human security â within the history and theory of the modern rise of the social realm from late eighteenth and nineteenth century Europe. Human security is the further expansion of social forms of governance under capitalism, more specifically a form of socialpolitik than realpolitik or biopolitics. Drawing on the work of historical sociologist Robert Castel and political theorist Hannah Arendt, the article develops an alternative framework with which to question the extent to which âlifeâ has become the subject of global intervention through the human security agenda
Genomic Indexing by Somatic Gene Recombination of mRNA/ncRNA â Does It Play a Role in Genomic Mosaicism, Memory Formation, and Alzheimerâs Disease?
Recent evidence indicates that genomic individuality of neurons, characterized by
DNA-content variation, is a common if not universal phenomenon in the human
brain that occurs naturally but can also show aberrancies that have been linked to
the pathomechanism of Alzheimerâs disease and related neurodegenerative disorders.
Etiologically, this genomic mosaic has been suggested to arise from defects of cell
cycle regulation that may occur either during brain development or in the mature
brain after terminal differentiation of neurons. Here, we aim to draw attention towards
another mechanism that can give rise to genomic individuality of neurons, with far reaching consequences. This mechanism has its origin in the transcriptome rather than
in replication defects of the genome, i.e., somatic gene recombination of RNA. We
continue to develop the concept that somatic gene recombination of RNA provides
a physiological process that, through integration of intronless mRNA/ncRNA into the
genome, allows a particular functional state at the level of the individual neuron to be
indexed. By insertion of defined RNAs in a somatic recombination process, the presence
of specific mRNA transcripts within a definite temporal context can be âfrozenâ and can
serve as an index that can be recalled at any later point in time. This allows information
related to a specific neuronal state of differentiation and/or activity relevant to a memory
trace to be fixed. We suggest that this process is used throughout the lifetime of each
neuron and might have both advantageous and deleterious consequences
Dendrimere Bisphosphonatrezeptoren zur molekularen Erkennung von basischen ProteinoberflÀchen
Im Rahmen dieser Arbeit wurde aus der, bereits aus den Arbeiten von Schrader et al. bekannten Bisphosphonatpinzette, die eine selektive Erkennungseinheit fĂŒr die basischen AminosĂ€uren Arginin und Lysin in nicht-wĂ€Ărigen Lösungen darstellt, ein multivalenter Rezeptor auf Dendrimerbasis entwickelt. Dieser wurde mit verschiedenen spektroskopische Methoden wie PFG-NMR, UV/Vis-Titration und Fluoreszenzmessungen auf seine AffinitĂ€t zu ProteinoberflĂ€chen in wĂ€Ăriger, gepufferter Lösung untersucht, die eine groĂe Anzahl basischer AminosĂ€uren prĂ€sentieren (z.B. Cytochrom c, BSA)
Predicting Intentions to Read Suicide Awareness Stories: The Role of Depression and Characteristics of the Suicidal Role Model
Background: Research on factors that influence the intention to read suicide awareness material is lacking. Aims: To identify how social and state similarities between the featured protagonist of a suicide awareness story and the audience impact on the intent to read similar stories. Method: Laboratory experiment with n = 104 students. Participants were randomly assigned to study groups. In the first group, the role model provided his personal story of crisis and was a student. In the second group, the content was identical but the model was socially dissimilar. The third group read about a topic unrelated to suicide. Depression, identification, and exposure intent were measured after the experiment. Conditional process analysis was carried out. Results: In the group featuring a once-suicidal role model with high social similarity, depression in the audience increased the intention to read similar material in the future via identification with the role model; 82% of individuals wanted to read similar material in the future, but only 50% wanted to do so in the group featuring a dissimilar person. Conclusion: Exposure intention increases via identification when role model and audience characteristics align regarding social traits and the experience of depression. These factors are relevant when developing campaigns targeting individuals with stories of recovery
Predicting Intentions to Read Suicide Awareness Stories: The Role of Depression and Characteristics of the Suicidal Role Model
Background: Research on factors that influence the intention to read suicide awareness material is lacking. Aims: To identify how social and state similarities between the featured protagonist of a suicide awareness story and the audience impact on the intent to read similar stories. Method: Laboratory experiment with n = 104 students. Participants were randomly assigned to study groups. In the first group, the role model provided his personal story of crisis and was a student. In the second group, the content was identical but the model was socially dissimilar. The third group read about a topic unrelated to suicide. Depression, identification, and exposure intent were measured after the experiment. Conditional process analysis was carried out. Results: In the group featuring a once-suicidal role model with high social similarity, depression in the audience increased the intention to read similar material in the future via identification with the role model; 82% of individuals wanted to read similar material in the future, but only 50% wanted to do so in the group featuring a dissimilar person. Conclusion: Exposure intention increases via identification when role model and audience characteristics align regarding social traits and the experience of depression. These factors are relevant when developing campaigns targeting individuals with stories of recovery
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