Rancang Bangun Portal Pembelajaran Online Menggunakan Framework Laravel

Saat ini pembelajaran telah berevolusi menggunakan media internet sehingga siswa dapat belajar dimanapun dan kapanpun. Web adalah salah satu teknologi yang memungkinkan pembelajaran online yang berbentuk e-learning menjadi mungkin. Untuk dapat membangun web secara efektif dan efisien maka pengembang menggunakan framework dalam pengembangan aplikasinya. Salah satu framework yang handal adalah Laravel.  Tujuan dari penelitian ini adalah melakukan pembangunan portal pembelajaran online dengan efektif menggunakan framework laravel. Pembangunan web tersebut dilakukan melalui beberapa tahapan antara lain analisis, perancangan, pembangunan, pengujian, dan implementasi. Untuk meningkatkan motivasi siswa dalam pembelajaran jarak jauh maka maka diimplementasikan beberapa elemen gamifikasi. Hasil dari penelitian ini adalah produk web elearning dengan beberapa fitur untuk pembelajaran jarak jauh. Penggunaan framework Laravel dan tahapan pengembangan web yang terstruktur telah berhasil menghasilkan produk web yang bisa dimanfaatkan serta dibangun secara efektif dan efisien. Implementasi aspek gamifikasi seperti leaderboard dan badge terbukti meningkatkan motivasi siswa dalam  mendalami materi yang diajarkan pada portal pembelajaran yang dibangun

Rancang Bangun Portal Pembelajaran Online Menggunakan Framework Laravel

Saat ini pembelajaran telah berevolusi menggunakan media internet sehingga siswa dapat belajar dimanapun dan kapanpun. Web adalah salah satu teknologi yang memungkinkan pembelajaran online yang berbentuk e-learning menjadi mungkin. Untuk dapat membangun web secara efektif dan efisien maka pengembang menggunakan framework dalam pengembangan aplikasinya. Salah satu framework yang handal adalah Laravel.  Tujuan dari penelitian ini adalah melakukan pembangunan portal pembelajaran online dengan efektif menggunakan framework laravel. Pembangunan web tersebut dilakukan melalui beberapa tahapan antara lain analisis, perancangan, pembangunan, pengujian, dan implementasi. Untuk meningkatkan motivasi siswa dalam pembelajaran jarak jauh maka maka diimplementasikan beberapa elemen gamifikasi. Hasil dari penelitian ini adalah produk web elearning dengan beberapa fitur untuk pembelajaran jarak jauh. Penggunaan framework Laravel dan tahapan pengembangan web yang terstruktur telah berhasil menghasilkan produk web yang bisa dimanfaatkan serta dibangun secara efektif dan efisien. Implementasi aspek gamifikasi seperti leaderboard dan badge terbukti meningkatkan motivasi siswa dalam  mendalami materi yang diajarkan pada portal pembelajaran yang dibangun

PENELANTARAN ISTERI OLEH SUAMI DALAM RUMAH TANGGA SEBAGAI ALASAN PERCERAIAN MENURUT UNDANG-UNDANG NOMOR 23 TAHUN 2004 TENTANG PENGHAPUSAN KEKERASAN DALAM RUMAH TANGGA

Penelantaran isteri oleh suami banyak terjadi di dalam lingkungan masyarakat sehingga menyebabkan perceraian antara keduanya maka dari itu diperlukannya perlindungan hukum terhadap korban yang diterlantarkan karena akan menjadi dampak yang buruk seperti trauma, gangguan mental dan lain sebagainya. Metode yang digunakan pada penelitian ini yaitu Metode pendekatan  yuridis normatif dengan spesifikasi penelitian deskriptif analitis dengan menggunakan tahap kepustakaan dan lapangan yang berfungsi untuk mencapai tujuan penelitian yaitu penelantaran isteri oleh suami yang menjadi alasan perceraian

Evaluation of salivary matrix metalloproteinase (MMP-8) in periodontal patients undergoing non-surgical periodontal therapy and mouthwash based on ozonated olive oil: A randomized clinical trial

Background: Extracellular matrix metalloproteinases (MMPs) play a pivotal role in the damage to the periodontal tissue in patients with periodontitis. Scaling and root planning (SRP) attempt to control the plaque amount and consequentially reduce the bacterial load. Non-surgical periodontal treatment could be integrated with drug therapy and physiotherapy procedures such as ozone therapy. The aim of this study was to evaluate in a cohort of patients with a diagnosis of periodontitis: (1) the efficacy of non-surgical periodontal therapy assisted by the use of ozonated olive oil-based mouthwash on salivary metalloproteinase (MMP-8) and (2) the reduction of periodontal indices. Methods: Ninety-six subjects with a diagnosis of periodontitis were enrolled in this study and randomly assigned to the study group (SRP + mouthwash) or control group (SRP). The study duration was 3 months. Data on MMP-8, plaque index (PI), bleeding on probing (BoP) and probing pocket depth (PPD) were recorded at T0, T1 (14 days), T2 (1 month) and T3 (6 months). Group differences were assessed using Student’s t-test for independent samples. Results: A significant improvement in PI, BoP, PPD and salivary MMP-8 levels was observed in both groups. An analysis of differences in relative changes of indices revealed the efficacy of ozonated olive oil in decreasing MMP-8 level. Simultaneously, it slowed the decrease of BoP index. Conclusions: Scaling and root plaining with the aid of ozonated olive oil mouthwash were found to be more effective on salivary MMP-8 reduction than scaling and root plaining alone

Knowledge of emergency management of avulsed teeth among Italian dentists-questionnaire study and next future perspectives

(1) Background: In Italy, about one fourth of all schoolchildren experience a trauma to the permanent dentition. Management of avulsion trauma is challenging and requires adherence to clinical protocols. The aim of this study was to investigate the management knowledge of avulsed teeth among Italian dentists and to promote the guidelines’ dissemination through the use of new social media. (2) Methods: The survey was carried out during the COVID-19 lockdown in Italy (March–May 2020). The questionnaire was sent anonymously to a total of 600 dentists. The questionnaire consisted of two parts. Part A—demographic and professional data and Part B—management of traumatic avulsion. (3) Results: The response rate was 50.6% and the mean fraction of correct responses was 0.524. Issues related to the therapeutic management of avulsed teeth were shown to be not well understood by the respondents. Professionals with qualifications in dentistry and those who declared to know the guidelines responded better, while other demographic and professional factors were insignificant. (4) Conclusions: Italian dentists’ knowledge of the management of avulsion trauma should be improved. Educational programs and campaigns must be undertaken to improve their awareness and adherence to the Italian and international guidelines

Evaluation of salivary matrix metalloproteinase (MMP-8) in periodontal patients undergoing non-surgical periodontal therapy and mouthwash based on ozonated olive oil: a randomized clinical trial

Background: Extracellular matrix metalloproteinases (MMPs) play a pivotal role in the damage to the periodontal tissue in patients with periodontitis. Scaling and root planning (SRP) attempt to control the plaque amount and consequentially reduce the bacterial load. Non-surgical periodontal treatment could be integrated with drug therapy and physiotherapy procedures such as ozone therapy. The aim of this study was to evaluate in a cohort of patients with a diagnosis of periodontitis: (1) the efficacy of non-surgical periodontal therapy assisted by the use of ozonated olive oil-based mouthwash on salivary metalloproteinase (MMP-8) and (2) the reduction of periodontal indices. Methods: Ninety-six subjects with a diagnosis of periodontitis were enrolled in this study and randomly assigned to the study group (SRP + mouthwash) or control group (SRP). The study duration was 3 months. Data on MMP-8, plaque index (PI), bleeding on probing (BoP) and probing pocket depth (PPD) were recorded at T0, T1 (14 days), T2 (1 month) and T3 (6 months). Group differences were assessed using Student’s t-test for independent samples. Results: A significant improvement in PI, BoP, PPD and salivary MMP-8 levels was observed in both groups. An analysis of differences in relative changes of indices revealed the efficacy of ozonated olive oil in decreasing MMP-8 level. Simultaneously, it slowed the decrease of BoP index. Conclusions: Scaling and root plaining with the aid of ozonated olive oil mouthwash were found to be more effective on salivary MMP-8 reduction than scaling and root plaining alone

IMPLEMENTASI UNDANG-UNDANG NOMOR 18 TAHUN 2003 TENTANG ADVOKAT DALAM KASUS PENYERANGAN TERHADAP HAKIM OLEH PENGACARA DI PENGADILAN NEGERI JAKARTA PUSAT

Undang-undang mengatur apa yang harus dilakukan dan atau apa yang bisa dilakukan serta apa yang dilarang. Ada kasus advokat berinisial DC menyerang Ketua Majelis Hakim berinisial HS dan hakim anggota berinisial DB saat persidangan berlangsung di Pengadilan Negeri Jakarta Pusat. Walaupun regulasi di suatu negara telah ditetapkan, namun jika unsur penanggung jawab dan otoritas tidak bekerja secara profesional, maka regulasi tersebut hanya akan menjadi penghias permata negara

Lack of Evidence for the Role of the p.(Ser96Ala) Polymorphism in Histidine-Rich Calcium Binding Protein as a Secondary Hit in Cardiomyopathies

Inherited forms of arrhythmogenic and dilated cardiomyopathy (ACM and DCM) are characterized by variable disease expression and age-related penetrance. Calcium (Ca$^{2+}$) is crucially important for proper cardiac function, and dysregulation of Ca$^{2+}$ homeostasis seems to underly cardiomyopathy etiology. A polymorphism, c.286T>G p.(Ser96Ala), in the gene encoding the histidine-rich Ca$^{2+}$ binding (HRC) protein, relevant for sarcoplasmic reticulum Ca$^{2+}$ cycling, has previously been associated with a marked increased risk of life-threatening arrhythmias among idiopathic DCM patients. Following this finding, we investigated whether p.(Ser96Ala) affects major cardiac disease manifestations in carriers of the phospholamban (PLN) c.40_42delAGA; p.(Arg14del) pathogenic variant (cohort 1); patients diagnosed with, or predisposed to, ACM (cohort 2); and DCM patients (cohort 3). We found that the allele frequency of the p.(Ser96Ala) polymorphism was similar across the general European-American population (control cohort, 40.3-42.2%) and the different cardiomyopathy cohorts (cohorts 1-3, 40.9-43.9%). Furthermore, the p.(Ser96Ala) polymorphism was not associated with life-threatening arrhythmias or heart failure-related events across various patient cohorts. We therefore conclude that there is a lack of evidence supporting the important role of the HRC p.(Ser96Ala) polymorphism as a modifier in cardiomyopathy, refuting previous findings. Further research is required to identify bona fide genomic predictors for the stratification of cardiomyopathy patients and their risk for life-threatening outcomes

A worldwide survey on incidence, management, and prognosis of oesophageal fistula formation following atrial fibrillation catheter ablation: the POTTER-AF study

AIMS Oesophageal fistula represents a rare but dreadful complication of atrial fibrillation catheter ablation. Data on its incidence, management, and outcome are sparse. METHODS AND RESULTS This international multicentre registry investigates the characteristics of oesophageal fistulae after treatment of atrial fibrillation by catheter ablation. A total of 553 729 catheter ablation procedures (radiofrequency: 62.9%, cryoballoon: 36.2%, other modalities: 0.9%) were performed, at 214 centres in 35 countries. In 78 centres 138 patients [0.025%, radiofrequency: 0.038%, cryoballoon: 0.0015% (P < 0.0001)] were diagnosed with an oesophageal fistula. Peri-procedural data were available for 118 patients (85.5%). Following catheter ablation, the median time to symptoms and the median time to diagnosis were 18 (7.75, 25; range: 0-60) days and 21 (15, 29.5; range: 2-63) days, respectively. The median time from symptom onset to oesophageal fistula diagnosis was 3 (1, 9; range: 0-42) days. The most common initial symptom was fever (59.3%). The diagnosis was established by chest computed tomography in 80.2% of patients. Oesophageal surgery was performed in 47.4% and direct endoscopic treatment in 19.8% and conservative treatment in 32.8% of patients. The overall mortality was 65.8%. Mortality following surgical (51.9%) or endoscopic treatment (56.5%) was significantly lower as compared to conservative management (89.5%) [odds ratio 7.463 (2.414, 23.072) P < 0.001]. CONCLUSION Oesophageal fistula after catheter ablation of atrial fibrillation is rare and occurs mostly with the use of radiofrequency energy rather than cryoenergy. Mortality without surgical or endoscopic intervention is exceedingly high

A call for public archives for biological image data

Public data archives are the backbone of modern biological and biomedical research. While archives for biological molecules and structures are well-established, resources for imaging data do not yet cover the full range of spatial and temporal scales or application domains used by the scientific community. In the last few years, the technical barriers to building such resources have been solved and the first examples of scientific outputs from public image data resources, often through linkage to existing molecular resources, have been published. Using the successes of existing biomolecular resources as a guide, we present the rationale and principles for the construction of image data archives and databases that will be the foundation of the next revolution in biological and biomedical informatics and discovery.Comment: 13 pages, 1 figur