La imagen y la narrativa como herramientas para el abordaje psicosocial en escenarios de violencia. Departamento de Norte de Santander, Santander y Cesar

No aplicaPara determinar la violencia en Colombia se debe tener en cuenta el dolor, el sufrimiento y el daño que han tenido una cantidad considerable de personas. De esta manera, son las acciones desde lo psicosocial en los escenarios de violencia un instrumento que permitió desarrollar un trabajo social, desde la determinación la restauración y la paz en los diferentes territorios donde se vive la violencia y que ha dejado una huella marcada. Cada uno de los estudiantes realizo un análisis a partir de un abordaje psicosocial desde los diferentes casos, con base en la narrativa e imágenes donde se permite examinar las situaciones y emergentes psicosociales que la violencia ha causado. Por ende, las herramientas utilizadas permiten generar un importante acompañamiento en las personas que han sido víctimas que han sufrido conflicto armado, desplazamiento forzado, llevar así al fortalecimiento y la resiliencia individual y de su núcleo familiar, que permite y ayuda a mejorar la calidad y bienestar de vida. Entre los temas abordados está el de Shimaia y la masacre en El Salado, donde se pueden analizar los diferentes sucesos de violencia y expectativa desde una historia de vida, y como desde cada evento traumático existe una forma de resarcirse. Para lograr generar fortalecimiento en las diferentes situaciones como lo fue la masacre en El Salado, se desarrollaron estrategias desde la perspectiva de acción psicosocial, que permiten ayudar en las víctimas y sobrevivientes afrontar situaciones difíciles y poder resistir el trauma a nivel psicológico ocasionado por el conflicto.To determine violence in Colombia, the pain, suffering and damage that a considerable number of people have had must be taken into account. In this way, psychosocial actions in scenarios of violence are an instrument that allowed the development of social work, from determination, restoration and peace in the different territories where violence is experienced and that has left a marked mark. Each of the students carried out an analysis based on a psychosocial approach from the different cases, based on the narrative and images where it is possible to examine the psychosocial situations and emergencies that violence has caused. Therefore, the tools used make it possible to generate important support for people who have been victims who have suffered armed conflict, forced displacement, thus leading to the strengthening and resilience of the individual and their family, which allows and helps to improve the quality and well-being of life. Among the topics addressed is that of Shimaia and the massacre in El Salado, where the different events of violence and expectations can be analyzed from a life story, and how from each traumatic event there is a way to compensate. In order to generate strengthening in different situations such as the massacre in El Salado, strategies were developed from the perspective of psychosocial action, which allow victims and survivors to face difficult situations and be able to resist the psychological trauma caused by the conflict

Educación Física y filosofía propuesta pedagógica para la Institución Educativa Distrital Nydia Quintero de Turbay (primer avance de investigación)

El presente proyecto de investigación, pretende explorar nuevas tendencias y propuestas que sean innovadoras, dentro el acto educativo. En consecuencia, el objetivo de la presente investigación es facilitar el aprendizaje de la filosofía y la educación física por medio de la articulación de las mismas, entendiendo estas os áreas como una sola, debido a su relación de conceptos a lo largo de la historia. Es necesario aclarar que la educación física y la filosofía son áreas especificas de el grado décimo de la I.E.D Nydia Quintero de Turbay, y al realizar el estudio mediante la recolección de datos se detectó la falta de interés de los jóvenes estudiantes por el área de filosofía y a la vez su interés por la asignatura de educación física. Desde este planteamiento es necesario aplicar nuevas estrategias que fomenten la motivación y el interés de los estudiantes frente a las áreas ya nombradas, para así mejorar la calidad y la producción de conocimientos, saberes y aportes en pro del mejoramiento de la calidad de vida de los estudiantes y la comunidad educativa de la institución

Molecular Tumor Board Improves Outcomes for Hispanic Patients With Advanced Solid Tumors

PURPOSEMultidisciplinary molecular tumor boards (MTBs) decode complex genomic data into clinical recommendations. Although MTBs are well-established in the oncology practice in developed countries, this strategy needs to be better explored in developing countries. Herein, we describe the possible benefits and limitations of the first MTB established in Colombia.METHODSDemographic, clinical, and genomic information was collected between August 2020 and November 2021. By mid-2020, an MTB strategy was created to discuss clinical cases with one or more genomic alterations identified by next-generation sequencing using an open-access virtual platform. We characterized the patient population as benefiting from the recommended treatment option. We assessed the benefits and access to available targeted therapies that have the potential to change clinical management by making recommendations to treating oncologists on the basis of genomic profiling. However, we did not assess the treatment oncologists' compliance with MTB recommendations because they were not intended to replace clinical judgment/standard of care.RESULTSA total of 146 patients were included in the discussions of the MTB. The median age was 59 years, and 59.6% were women. Genomic results prompting a change in therapeutic decisions were obtained in 53.1% of patients (95% CI, 44.9 to 61.3). The most prevalent malignancy was non–small-cell lung cancer (51%). Other malignancies represented 60%, 50%, and 30% of patients with soft-tissue sarcomas, brain tumors, and breast cancer, respectively.CONCLUSIONUsing an open-access virtual platform, MTBs were feasible in low- and middle-income countries on the basis of the capability to provide the benefits and access to available targeted therapies that are not standard of care. Furthermore, MTB recommendations were made available to the treating oncologist in different locations across Colombia, providing the option to modify clinical management in most of these patients

Genomic Landscape of Primary Resistance to Osimertinib Among Hispanic Patients with EGFR-Mutant Non-Small Cell Lung Cancer (NSCLC): Results of an Observational Longitudinal Cohort Study

Background: Epidermal growth factor receptor (EGFR) mutations (EGFRm) represent one of the most common genomic alterations identified among patients with non-small cell lung cancer (NSCLC). Several targeted agents for patients with EGFRm have been proven safe and effective, including the third-generation tyrosine kinase inhibitor (TKI) osimertinib. Nonetheless, some patients will present with or develop EGFR-TKI resistance mechanisms. Objective: We characterized the genomic landscape of primary resistance to osimertinib among Hispanic patients with EGFR-mutant NSCLC. Methods: An observational longitudinal cohort study was conducted with two groups of patients, those with intrinsic resistance (cohort A) and those with long-term survival (cohort B). All patients were treated and followed between January 2018 and May 2022. All patients were assessed for Programmed Cell Death Ligand 1 (PD-L1) expression and Bcl-2-like protein 11 (BIM)/AXL mRNA expression before starting TKI. After 8 weeks of treatment, a liquid biopsy was performed to determine the presence of circulating free DNA (cfDNA), and next-generation sequencing (NGS) was used to identify mutations at the time of progression. In both cohorts, overall response rate (ORR), progression-free survival (PFS), and overall survival (OS) were evaluated. Results: We found a homogeneous distribution of EGFR-sensitizing mutations in both cohorts. For cohort A, exon 21 mutations were more common than exon 19 deletions (ex19dels) for cohort B (P = 0.0001). The reported ORR for osimertinib was 6.3% and 100% for cohorts A and B, respectively (P = 0.0001). PFS was significantly higher in cohort B (27.4 months vs. 3.1 months; P = 0.0001) and ex19del patients versus L858R (24.5 months, 95% confidence interval [CI] 18.2-NR), vs. 7.6 months, 95% CI 4.8-21.1; P = 0.001). OS was considerably lower for cohort A (20.1 months vs. 36.0 months; P = 0.0001) and was better for patients with ex19del, no brain metastasis, and low tumor mutation burden. At the time of progression, more mutations were found in cohort A, identifying off-target alterations more frequently, including TP53, RAS, and RB1. Conclusion: EGFR-independent alterations are common among patients with primary resistance to osimertinib and significantly impact PFS and OS. Our results suggest that among Hispanic patients, other variables associated with intrinsic resistance include the number of commutations, high levels AXL mRNA, and low levels of BIM mRNA, T790M de novo, EGFR p.L858R presence, and a high tumoral mutational burden