805 research outputs found
Delayed reception of live blowfly (Calliphora vicina and Chrysomya rufifacies) larval samples: implications for minimum postmortem interval estimates.
Forensic entomology evidence collected by police and mortuary staff may be delayed in getting to the entomologist. Live samples may continue developing and alter minimum postmortem interval (PMImin) estimates. This study investigated development of simulated evidential samples of Calliphora vicina Robineau-Desvoidy and Chrysomya rufifacies (Macquart) (Diptera: Calliphoridae) maggots. Maggots of each species were studied in three developmental classes: "small" (late second/early third instar), "mid" (mid third instar) and "large" (late third instar). Seven replicates of 11 maggots in each class were assigned without food to four treatments: (1) 24 h at 20 °C; (2) 24 h at 4 °C; (3) 48 h at 20 °C and (4) 48 h at 4 °C. There was a significant difference in absolute length change across treatments, reflecting size for C. vicina, and interaction between size, time and temperature for Ch. rufifacies. Calliphora vicina maggots showed minimal mortality, and most second instar larvae moulted by the experiment's end. Chrysomya rufifacies showed heavy mortality and minimal moulting from the second to third instar. Only "large" Ch. rufifacies maggots kept at room temperature for 48 h pupariated. Since these results confirm that development can continue in live unfed maggot samples after their collection, it is not advisable to delay their preservation
Ontogenesis versus Morphogenesis towards an Anti-realist Model of the Constitution of Society
This article firstly criticizes Margaret Archerâs Morphogenetic Approach for being indecisive about the realist notion of emergence it proposes as well as for her inadequate account of structural conditioning. It is argued that critical realistsâ conceptualizations of emergence cannot but lead to inconsistencies about the adequate placement of agents as parts of emergent entities. The inconsistencies to which these conceptualizations lead necessitate an anti-realist model of the constitution of societies which takes into account that social structures are existentially dependent upon ideational elaboration. This alternative anti-realist theoretical perspective is provided by Ontogenesis, within the framework of which the realistsâ idea of the ânecessary and internal relationsâ give their place to the ontological pervasiveness of the culturally shared imaginary schemata. Archerâs denial of a collective synchronic impact to social forms is implied in her analysis of morphogenetic cycles, according to which, structural elaboration post-dates social interaction; and this denial is also expressed in this very idea of emergent structures. Instead, for Ontogenesis, social forms are synchronically dependent on the collective impact of the differently socially placed agents, who have different interests and material resources, and whose interaction only becomes meaningful when drawing on these culturally shared imaginary schemata
Reducing Constraints in a Higher Dimensional Extension of the Randall and Sundrum Model
In order to investigate the phenomenological implications of warped spaces in
more than five dimensions, we consider a dimensional extension to
the Randall and Sundrum model in which the space is warped with respect to a
single direction by the presence of an anisotropic bulk cosmological constant.
The Einstein equations are solved, giving rise to a range of possible spaces in
which the additional spaces are warped. Here we consider models in
which the gauge fields are free to propagate into such spaces. After carrying
out the Kaluza Klein (KK) decomposition of such fields it is found that the KK
mass spectrum changes significantly depending on how the additional
dimensions are warped. We proceed to compute the lower bound on the KK mass
scale from electroweak observables for models with a bulk
gauge symmetry and models with a bulk gauge
symmetry. It is found that in both cases the most favourable bounds are
approximately TeV, corresponding to a mass of the first gauge
boson excitation of about 4-6 TeV. Hence additional warped dimensions offer a
new way of reducing the constraints on the KK scale.Comment: 27 pages, 15 figures, v3: Additional comments in sections 1, 2 and 4.
New appendix added. Five additional figures. References adde
The Effective Lagrangian for Bulk Fermions in Models with Extra Dimensions
We compute the dimension 6 effective Lagrangian arising from the tree level
integration of an arbitrary number of bulk fermions in models with warped extra
dimensions. The coefficients of the effective operators are written in terms of
simple integrals of the metric and are valid for arbitrary warp factors, with
or without an infrared brane, and for a general Higgs profile. All relevant
tree level fermion effects in electroweak and flavor observables can be
computed using this effective Lagrangian.Comment: 22 pages. V2: typos corrected, matches published versio
Clinical and echocardiographic features of aorto-atrial fistulas
Aorto-atrial fistulas (AAF) are rare but important pathophysiologic conditions of the aorta and have varied presentations such as acute pulmonary edema, chronic heart failure and incidental detection of the fistula. A variety of mechanisms such as aortic dissection, endocarditis with pseudoaneurysm formation, post surgical scenarios or trauma may precipitate the fistula formation. With increasing survival of patients, particularly following complex aortic reconstructive surgeries and redo valve surgeries, recognition of this complication, its clinical features and echocardiographic diagnosis is important. Since physical exam in this condition may be misleading, echocardiography serves as the cornerstone for diagnosis. The case below illustrates aorto-left atrial fistula formation following redo aortic valve surgery with slowly progressive symptoms of heart failure. A brief review of the existing literature of this entity is presented including emphasis on echocardiographic diagnosis and treatment
Recommended from our members
ââŠthe point is to change itâ: Critical realism and human geography
This paper picks up themes discussed in Coxâs (2013) âNotes on a brief encounter: critical realism, historical materialism and human geographyâ. I argue that perhaps the encounter was more complex than Cox allows. At core Cox underplays, or marginalises, the discussion of causality and dismisses the significance of ontology stressing instead epistemology. The paper makes a case for another reading of the debate, one that has continuing significance
Electroweak Constraints on Warped Geometry in Five Dimensions and Beyond
Here we consider the tree level corrections to electroweak (EW) observables
from standard model (SM) particles propagating in generic warped extra
dimensions. The scale of these corrections is found to be dominated by three
parameters, the Kaluza-Klein (KK) mass scale, the relative coupling of the KK
gauge fields to the Higgs and the relative coupling of the KK gauge fields to
fermion zero modes. It is found that 5D spaces that resolve the hierarchy
problem through warping typically have large gauge-Higgs coupling. It is also
found in where the additional dimensions are warped the relative
gauge-Higgs coupling scales as a function of the warp factor. If the warp
factor of the additional spaces is contracting towards the IR brane, both the
relative gauge-Higgs coupling and resulting EW corrections will be large.
Conversely EW constraints could be reduced by finding a space where the
additional dimension's warp factor is increasing towards the IR brane. We
demonstrate that the Klebanov Strassler solution belongs to the former of these
possibilities.Comment: 18 pages, 3 figures (references added) version to appear in JHE
Research productivity and academicsâ conceptions of research
This paper asks the question: do people with different levels of research productivity
and identification as a researcher think of research differently? It discusses a
study that differentiated levels of research productivity among English and Australian
academics working in research-intensive environments in three broad discipline areas:
science, engineering and technology; social science and humanities; and medicine and
health sciences. The paper explores the different conceptions of research held by these
academics in terms of their levels of research productivity, their levels of research training,
whether they considered themselves an active researcher and a member of a research team,
and their disciplinary differences
Enhancer of Zeste Homolog 2 Induces Pulmonary Artery Smooth Muscle Cell Proliferation
Pulmonary Arterial Hypertension (PAH) is a progressively devastating disease characterized by excessive proliferation of the Pulmonary Arterial Smooth Muscle Cells (PASMCs). Studies suggest that PAH and cancers share an apoptosis-resistant state featuring excessive cell proliferation. The proliferation of cancer cells is mediated by increased expression of Enhancer of Zeste Homolog 2 (EZH2), a mammalian histone methyltransferase that contributes to the epigenetic silencing of target genes. However, the role of EZH2 in PAH has not been studied. In this study, it is hypothesized that EZH2 could play a role in the proliferation of PASMCs.In the present study, the expression patterns of EZH2 were investigated in normal and hypertensive mouse PASMCs. The effects of EZH2 overexpression on the proliferation of human PASMCs were tested. PASMCs were transfected with EZH2 or GFP using nucleofector system. After transfection, the cells were incubated for 48 hours at 37°C. Proliferation and cell cycle analysis were performed using flow cytometry. Apoptosis of PASMCs was determined using annexin V staining and cell migration was tested by wound healing assay.EZH2 protein expression in mouse PASMCs were correlated with an increase in right ventricular systolic pressure and Right Ventricular Hypertrophy (RVH). The overexpression of EZH2 in human PASMCs enhances proliferation, migration, and decrease in the rate of apoptosis when compared to GFP-transfected cells. In the G2/M phase of the EZH2 transfected cells, there was a 3.5 fold increase in proliferation, while there was a significant decrease in the rate of apoptosis of PASMCs, when compared to control.These findings suggest that EZH2 plays a role in the migration and proliferation of PASMCs, which is a major hallmark in PAH. It also suggests that EZH2 could play a role in the development of PAH and can serve as a potential target for new therapies for PAH
Suppressing Electroweak Precision Observables in 5D Warped Models
We elaborate on a recently proposed mechanism to suppress large contributions
to the electroweak precision observables in five dimensional (5D) warped
models, without the need for an extended 5D gauge sector. The main ingredient
is a modification of the AdS metric in the vicinity of the infrared (IR) brane
corresponding to a strong deviation from conformality in the IR of the 4D
holographic dual. We compute the general low energy effective theory of the 5D
warped Standard Model, emphasizing additional IR contributions to the wave
function renormalization of the light Higgs mode. We also derive expressions
for the S and T parameters as a function of a generic 5D metric and zero-mode
wave functions. We give an approximate formula for the mass of the radion that
works even for strong deviation from the AdS background. We proceed to work out
the details of an explicit model and derive bounds for the first KK masses of
the various bulk fields. The radion is the lightest new particle although its
mass is already at about 1/3 of the mass of the lightest resonances, the KK
states of the gauge bosons. We examine carefully various issues that can arise
for extreme choices of parameters such as the possible reintroduction of the
hierarchy problem, the onset of nonperturbative physics due to strong IR
curvature or the creation of new hierarchies near the Planck scale. We conclude
that a KK scale of 1 TeV is compatible with all these constraints.Comment: 44 pages, 11 figures, references adde
- âŠ