Tradução e validação da escala Parent-adolescent Communication Scale: tecnologia para prevenção de DST/HIV

OBJECTIVES: accomplishment of the transcultural adaptation of the Parent-adolescent Communication Scale, which evaluates the frequency of communication between parents and children concerning the subjects related to sex, condom, DST, HIV and pregnancy. METHOD: Methodological research of quantitative approach, accomplished with 313 adolescent pupils of the feminine sex in the 14 to 18 year age group in Fortaleza-CE. The content validity was carried through by means of the initial translation, back translation, pre-final version and final version, being analyzed by a committee of specialists; the reliability was verified by the Cronbach's Alpha and ascertained by testing the hypotheses and test-retest within five weeks. The scale was applied via computer in the online modality in the period November/2010 to January/2011. RESULTS: The version of the instrument in Portuguese presented an Alpha of 0.86 regarding the validity of the structure, was partially verified since the testing of the hypotheses of the contracted group was not confirmed. CONCLUSION: The version of the instrument adapted for Portuguese is considered valid and reliable in the study sample.OBJETIVOS: realizar la adaptación transcultural de la escala Parent-adolescent Communication Scale, la cual evalúa la frecuencia de comunicación entre padres e hijas acerca de temas relacionados a sexo, preservativo, EST, HIV y embarazo. MÉTODO: investigación metodológica, de abordaje cuantitativo, realizada con 313 adolescentes escolares del sexo femenino, en el intervalo de edad de 14 a 18 años en la ciudad de Fortaleza, estado de Ceará. La validad de contenido fue realizada por medio de la traducción inicial, backtranslation, versión pre-final y versión final, siendo analizada por un comité de especialistas; la confiabilidad fue verificada por el alfa de Cronbach y averiguada por la prueba de hipótesis y reprueba en cinco semanas. La escala fue aplicada vía computador en la modalidad online, en el período de noviembre/2010 la enero/2011. RESULTADOS: la versión del instrumento en portugués presentó un alfa de 0,86; la validad de constructo, fue parcialmente verificada, ya que la prueba de la hipótesis por grupo contratados no fue confirmada. CONCLUSIÓN: la versión del instrumento adaptada para el portugués es considerada válida y confiable en la muestra de este estudio.OBJETIVO: realizar a adaptação transcultural da escala Parent-adolescent Communication Scale, a qual avalia a frequência de comunicação entre pais e filhas acerca de temas relacionados a sexo, preservativo, doenças sexualmente transmissíveis, vírus da imonodeficiência humana e gravidez. MÉTODO: pesquisa metodológica, de abordagem quantitativa, realizada com 313 adolescentes escolares do sexo feminino, na faixa etária dos 14 aos 18 anos, em Fortaleza, CE. A validade de conteúdo foi realizada por meio da tradução inicial, backtranslation, versão pré-final e versão final, sendo analisada por comitê de especialistas, a confiabilidade foi verificada pelo alfa de Cronbach e averiguada pela testagem de hipóteses e teste-reteste em cinco semanas. A escala foi aplicada via computador na modalidade online, no período de novembro/2010 a janeiro/2011. RESULTADOS: a versão do instrumento em português apresentou alfa de 0,86; quanto à validade de constructo, foi parcialmente verificada, visto que a testagem de hipóteses por grupo contrastado não foi confirmada. CONCLUSÃO: a versão do instrumento adaptada para o português é considerada válida e confiável na amostra de estudo

Convalescent plasma for COVID-19 in hospitalised patients : an open-label, randomised clinical trial

Background: The effects of convalescent plasma (CP) therapy in hospitalised patients with coronavirus disease 2019 (COVID-19) remain uncertain. This study investigates the effect of CP on clinical improvement in these patients. Methods: This is an investigator-initiated, randomised, parallel arm, open-label, superiority clinical trial. Patients were randomly (1:1) assigned to two infusions of CP plus standard of care (SOC) or SOC alone. The primary outcome was the proportion of patients with clinical improvement 28 days after enrolment. Results: A total of 160 (80 in each arm) patients (66.3% critically ill, 33.7% severely ill) completed the trial. The median (interquartile range (IQR)) age was 60.5 (48–68) years; 58.1% were male and the median (IQR) time from symptom onset to randomisation was 10 (8–12) days. Neutralising antibody titres >1:80 were present in 133 (83.1%) patients at baseline. The proportion of patients with clinical improvement on day 28 was 61.3% in the CP+SOC group and 65.0% in the SOC group (difference −3.7%, 95% CI −18.8–11.3%). The results were similar in the severe and critically ill subgroups. There was no significant difference between CP+SOC and SOC groups in pre-specified secondary outcomes, including 28-day mortality, days alive and free of respiratory support and duration of invasive ventilatory support. Inflammatory and other laboratory marker values on days 3, 7 and 14 were similar between groups. Conclusions: CP+SOC did not result in a higher proportion of clinical improvement on day 28 in hospitalised patients with COVID-19 compared to SOC alone