CONSEQUÊNCIAS BUCAIS DOS TRANSTORNOS ALIMENTARES

Transtornos alimentares (TA) são considerados síndromes psiquiátricas que podem vir acompanhados de comprometimentos do estado nutricional, bucal e práticas inadequadas para controlar o peso. A Bulimia e Anorexia Nervosa são exemplos desses transtornos e ambas são caracterizadas pela preocupação com o corpo e o medo excessivo de ganhar peso, tais características são levadas de maneira descontrolada e doentia. Na boca, há consequências como erosão dentária, xerostomia, halitose e aumento de volume das glândulas salivares. O objetivo do trabalho é fornecer maiores informações sobre o que ocorre na cavidade bucal em pessoas que possuem transtorno alimentar e a importância do cirurgião dentista, que pode ser o diagnosticador. Trata-se de uma revisão de literatura a partir de pesquisas de trabalhos científicos por meio do Google Acadêmico, onde foi pesquisado sobre transtornos alimentares e sua relação com a saúde bucal. Os transtornos mais comuns são Bulimia e Anorexia Nervosa, que trazem consequências físicas, como as orais, e mentais. Nas consequências orais, vai haver o desgaste dos dentes (erosão dental), xerostomia (boca seca) e halitose (mal hálito) em decorrência do vômito induzido. Com isso, é o dentista a ver os primeiros sinais e muitas vezes levar ao diagnóstico. Ele atua no tratamento oral, mas deve trabalhar em conjunto com nutricionista; psicólogo; psiquiatra. A partir disso é possível perceber a relação de transtornos alimentares com a saúde bucal e a importância do cirurgião dentista durante todo o processo

In Vitro and In Silico Evaluation of Cholinesterase Inhibition by Alkaloids Obtained from Branches of Abuta panurensis Eichler

Alkaloids are natural products known as ethnobotanicals that have attracted increasing attention due to a wide range of their pharmacological properties. In this study, cholinesterase inhibitors were obtained from branches of Abuta panurensis Eichler (Menispermaceae), an endemic species from the Amazonian rainforest. Five alkaloids were isolated, and their structure was elucidated by a combination of 1D and 2D H-1 and C-13 NMR spectroscopy, HPLC-MS, and high-resolution MS: Lindoldhamine isomer m/z 569.2674 (1), stepharine m/z 298.1461 (2), palmatine m/z 352.1616 (3), 5-N-methylmaytenine m/z 420.2669 (4) and the N-trans-feruloyltyramine m/z 314.1404 (5). The compounds 1, 3, and 5 were isolated from A. panurensis for the first time. Interaction of the above-mentioned alkaloids with acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) enzymes was investigated in silico by molecular docking and molecular dynamics. The molecules under investigation were able to bind effectively with the active sites of the AChE and BChE enzymes. The compounds 1-4 demonstrated in vitro an inhibitory effect on acetylcholinesterase with IC50 values in the range of 19.55 mu M to 61.24 mu M. The data obtained in silico corroborate the results of AChE enzyme inhibition.Peer reviewe

Brazilian Flora 2020: Leveraging the power of a collaborative scientific network

International audienceThe shortage of reliable primary taxonomic data limits the description of biological taxa and the understanding of biodiversity patterns and processes, complicating biogeographical, ecological, and evolutionary studies. This deficit creates a significant taxonomic impediment to biodiversity research and conservation planning. The taxonomic impediment and the biodiversity crisis are widely recognized, highlighting the urgent need for reliable taxonomic data. Over the past decade, numerous countries worldwide have devoted considerable effort to Target 1 of the Global Strategy for Plant Conservation (GSPC), which called for the preparation of a working list of all known plant species by 2010 and an online world Flora by 2020. Brazil is a megadiverse country, home to more of the world's known plant species than any other country. Despite that, Flora Brasiliensis, concluded in 1906, was the last comprehensive treatment of the Brazilian flora. The lack of accurate estimates of the number of species of algae, fungi, and plants occurring in Brazil contributes to the prevailing taxonomic impediment and delays progress towards the GSPC targets. Over the past 12 years, a legion of taxonomists motivated to meet Target 1 of the GSPC, worked together to gather and integrate knowledge on the algal, plant, and fungal diversity of Brazil. Overall, a team of about 980 taxonomists joined efforts in a highly collaborative project that used cybertaxonomy to prepare an updated Flora of Brazil, showing the power of scientific collaboration to reach ambitious goals. This paper presents an overview of the Brazilian Flora 2020 and provides taxonomic and spatial updates on the algae, fungi, and plants found in one of the world's most biodiverse countries. We further identify collection gaps and summarize future goals that extend beyond 2020. Our results show that Brazil is home to 46,975 native species of algae, fungi, and plants, of which 19,669 are endemic to the country. The data compiled to date suggests that the Atlantic Rainforest might be the most diverse Brazilian domain for all plant groups except gymnosperms, which are most diverse in the Amazon. However, scientific knowledge of Brazilian diversity is still unequally distributed, with the Atlantic Rainforest and the Cerrado being the most intensively sampled and studied biomes in the country. In times of “scientific reductionism”, with botanical and mycological sciences suffering pervasive depreciation in recent decades, the first online Flora of Brazil 2020 significantly enhanced the quality and quantity of taxonomic data available for algae, fungi, and plants from Brazil. This project also made all the information freely available online, providing a firm foundation for future research and for the management, conservation, and sustainable use of the Brazilian funga and flora