Vitamin K as a diet supplement with impact in human health: current evidence in age-related idseases

Vitamin K health benefits have been recently widely shown to extend beyond blood homeostasis and implicated in chronic low-grade inflammatory diseases such as cardiovascular disease, osteoarthritis, dementia, cognitive impairment, mobility disability, and frailty. Novel and more efficient nutritional and therapeutic options are urgently needed to lower the burden and the associated health care costs of these age-related diseases. Naturally occurring vitamin K comprise the phylloquinone (vitamin K1), and a series of menaquinones broadly designated as vitamin K2 that differ in source, absorption rates, tissue distribution, bioavailability, and target activity. Although vitamin K1 and K2 sources are mainly dietary, consumer preference for diet supplements is growing, especially when derived from marine resources. The aim of this review is to update the reader regarding the specific contribution and effect of each K1 and K2 vitamers in human health, identify potential methods for its sustainable and cost-efficient production, and novel natural sources of vitamin K and formulations to improve absorption and bioavailability. This new information will contribute to foster the use of vitamin K as a health-promoting supplement, which meets the increasing consumer demand. Simultaneously, relevant information on the clinical context and direct health consequences of vitamin K deficiency focusing in aging and age-related diseases will be discussed.info:eu-repo/semantics/publishedVersio

Critical issues in ionospheric data quality and implications for scientific studies

Ionospheric data are valuable records of the behavior of the ionosphere, solar activity, and the entire Sun-Earth system. The data are critical for both societally important services and scientific investigations of upper atmospheric variability. This work investigates some of the difficulties and pitfalls in maintaining long-term records of geophysical measurements. This investigation focuses on the ionospheric parameters contained in the historical data sets within the National Oceanic and Atmospheric Administration National Geophysical Data Center and Space Physics Interactive Data Resource databases. These archives include data from approximately 100 ionosonde stations worldwide, beginning in the early 1940s. Our study focuses on the quality and consistency of ionosonde data accessible via the primary Space Physics Interactive Data Resource node located within the National Oceanic and Atmospheric Administration National Geophysical Data Center and the World Data Center for Solar-Terrestrial Physics located in Boulder, Colorado. We find that, although the Space Physics Interactive Data Resource archives contained an impressive amount of high-quality data, specific problems existed involving missing and noncontiguous data sets, long-term variations or changes in methodologies and analysis procedures used, and incomplete documentation. The important lessons learned from this investigation are that the data incorporated into an archive must have clear traceability back to the primary source, including scientific validation by the contributors, and that the historical records must have associated metadata that describe relevant nuances in the observations. Although this report only focuses on historical ionosonde data in National Oceanic and Atmospheric Administration databases, we feel that these findings have general applicability to environmental scientists interested in using long-term geophysical data sets for climate and global change research.Peer ReviewedPostprint (published version

Low-field microwave absorption and magnetoresistance in iron nanostructures grown by electrodeposition on n-type lightly-doped silicon substrates

In this study we investigate magnetic properties, surface morphology and crystal structure in iron nanoclusters electrodeposited on lightly-doped (100) n-type silicon substrates. Our goal is to investigate the spin injection and detection in the Fe/Si lateral structures. The samples obtained under electric percolation were characterized by magnetoresistive and magnetic resonance measurements with cycling the sweeping applied field in order to understand the spin dynamics in the as-produced samples. The observed hysteresis in the magnetic resonance spectra, plus the presence of a broad peak in the non-saturated regime confirming the low field microwave absorption (LFMA), were correlated to the peaks and slopes found in the magnetoresistance curves. The results suggest long range spin injection and detection in low resistive silicon and the magnetic resonance technique is herein introduced as a promising tool for analysis of electric contactless magnetoresistive samples.Comment: 12 pages, 5 figure

Evolution of Bilateral Capital Flows to Developing Countries at Intensive and Extensive Margins

The capital flows network has changed substantially, bringing new investors and target economies into play. Related, a recent intensification of capital flows to low income countries (LICs) has posed a number of questions. Most importantly, the very nature of those flows and important factors affecting foreign investors decision which can ultimately affect growth prospects of low income countries (together with an issue of sustainability) remain open for an academic probe. Due to an existence of a share of costs which is fixed in nature, there is a need to analyze capital flows and their evolution at two margins: intensive and extensive. This paper presents a parsimonious theoretical account that is consequently mapped into an econometric framework where we allow for two-tier decisions and cross-sectional dependence. Results indicate that market entry costs affect investment decisions pertinent to the LICs, consistently with the static theory. However, persistence in extensive margin eliminates this effect once dynamics is allowed for.Heterogeneous Panel

Cosmological constant constraints from observation-derived energy condition bounds and their application to bimetric massive gravity

Among the various possibilities to probe the theory behind the recent accelerated expansion of the universe, the energy conditions (ECs) are of particular interest, since it is possible to confront and constrain the many models, including different theories of gravity, with observational data. In this context, we use the ECs to probe any alternative theory whose extra term acts as a cosmological constant. For this purpose, we apply a model-independent approach to reconstruct the recent expansion of the universe. Using Type Ia supernova, baryon acoustic oscillations and cosmic-chronometer data, we perform a Markov Chain Monte Carlo analysis to put constraints on the effective cosmological constant $\Omega^0_{\rm eff}$. By imposing that the cosmological constant is the only component that possibly violates the ECs, we derive lower and upper bounds for its value. For instance, we obtain that $0.59 < \Omega^0_{\rm eff} < 0.91$ and $0.40 < \Omega^0_{\rm eff} < 0.93$ within, respectively, $1\sigma$ and $3\sigma$ confidence levels. In addition, about 30\% of the posterior distribution is incompatible with a cosmological constant, showing that this method can potentially rule it out as a mechanism for the accelerated expansion. We also study the consequence of these constraints for two particular formulations of the bimetric massive gravity. Namely, we consider the Visser's theory and the Hassan and Roses's massive gravity by choosing a background metric such that both theories mimic General Relativity with a cosmological constant. Using the $\Omega^0_{\rm eff}$ observational bounds along with the upper bounds on the graviton mass we obtain constraints on the parameter spaces of both theories.Comment: 11 pages, 4 figures, 1 tabl

Avaliação dos impactos ambientais do sistema de produção integrada de uva de mesa na região do Submédio São Francisco.

O objetivo deste estudo foi analisar os impactos ambientais do sistema de produção integrada de uva na região do Submédio São Francisco, que é o principal pólo de exportação desta fruta no país

Análise dos custos de produção e da rentabilidade do sistema típico de produção de banana orgânica, na região do Vale do Submédio São Francisco.

Edição dos Resumos do 7 Congresso Brasileiro de Agroecologia, Fortaleza, dez. 2011