Manuscritos atípicos, papeles de actor y compañías del siglo XVI

(parte a firma Vaccari: pp. 34-52 e 56-62)(Part of the company Vaccari: pp. 34-52 e 56-62

Report from the Expert Panel on the evaluation of the VRZs during the 2018/19 fishing season

In July 2018 ARK (the Association of Responsible Krill harvesting companies) launched a set of voluntary measures, known as ARK’s Commitment, which were proposed to improve the long-term sustainability of the krill fishery. The Commitment was initiated with support from Greenpeace, WWF and The Pew Charitable Trusts as a precautionary action whilst CCAMLR developed spatial management of the krill fishery in Area 48. The Commitment, which took the form of Voluntary Restriction Zones (VRZs), was implemented for the 2018-19 fishing season. The krill fishing fleet associated with ARK agreed to avoid fishing in an area of up to 40 km from penguin colonies in Subarea 48.1 during the penguin breeding season

Treatment of giant congenital melanocytic nevi with cultured epithelial autografts: Clinical and histopathological analysis

[Introduction] Curettage and dermabrasion are effective in the treatment of giant congenital melanocytic nevi (GCMN); however, local infection and hypertrophic scar formation are major issues. Thus, we applied cultured epithelial autografts (CEA) on skin defects after curettage or abrasion of GCMN and assessed the postoperative outcomes. [Methods] Seven nevi lesions of five patients (aged 3 months to 24 years) were treated with CEA after curettage or abrasion with a dermatome or a surgical bar, respectively. We assessed the postoperative outcomes, including CEA take ratio, erosion and/or ulcer formation in the acute phase, hospitalization days, Vancouver scar scale, and color improvement one year after the operation. In addition, a histological evaluation of a skin biopsy was performed over one year after the operation. [Results] The CEAs took well on the wound, and the wound surface was mostly epithelized by postoperative day 7 in all cases. While hypertrophic scar formation and slight pigmentation were observed in some lesions, the color was improved in all of the treated lesions. Histopathological examination revealed that the regenerated epidermis had stratified keratinocytes with rete ridges, and the dermal layer without nevus cells regenerated above the remaining dermis layer. [Conclusions] In this study, we found that early epithelialization and regeneration of the dermal layer was achieved after the application of CEA, suggesting that CEA could be an effective option after curettage or abrasion of GCMN

Phenotypic heterogeneity and genetic modification of P102L inherited prion disease in an international series

The largest kindred with inherited prion disease P102L, historically Gerstmann-Sträussler-Scheinker syndrome, originates from central England, with émigrés now resident in various parts of the English-speaking world. We have collected data from 84 patients in the large UK kindred and numerous small unrelated pedigrees to investigate phenotypic heterogeneity and modifying factors. This collection represents by far the largest series of P102L patients so far reported. Microsatellite and genealogical analyses of eight separate European kindreds support multiple distinct mutational events at a cytosine-phosphate diester-guanidine dinucleotide mutation hot spot. All of the smaller P102L kindreds were linked to polymorphic human prion protein gene codon 129M and were not connected by genealogy or microsatellite haplotype background to the large kindred or each other. While many present with classical Gerstmann-Sträussler-Scheinker syndrome, a slowly progressive cerebellar ataxia with later onset cognitive impairment, there is remarkable heterogeneity. A subset of patients present with prominent cognitive and psychiatric features and some have met diagnostic criteria for sporadic Creutzfeldt-Jakob disease. We show that polymorphic human prion protein gene codon 129 modifies age at onset: the earliest eight clinical onsets were all MM homozygotes and overall age at onset was 7 years earlier for MM compared with MV heterozygotes (P = 0.02). Unexpectedly, apolipoprotein E4 carriers have a delayed age of onset by 10 years (P = 0.02). We found a preponderance of female patients compared with males (54 females versus 30 males, P = 0.01), which probably relates to ascertainment bias. However, these modifiers had no impact on a semi-quantitative pathological phenotype in 10 autopsied patients. These data allow an appreciation of the range of clinical phenotype, modern imaging and molecular investigation and should inform genetic counselling of at-risk individuals, with the identification of two genetic modifiers

Dynamical Gauge Symmetry Breaking in SU(3)L⊗U(1)XSU(3)_L\otimes U(1)_X Extension of the Standard Model

We study the $SU(3)_L\otimes U(1)_X$ extension of the Standard model with a strong U(1) coupling. We argue that current experiments limit this coupling to be relatively large. The model is dynamically broken to the Standard $SU(2)_L \otimes U(1)$ model at the scale of a few TeV with all the extra gauge bosons and the exotic quarks acquiring masses much larger than the scale of electroweak symmetry breaking. Furthermore we find that the model leads to large dynamical mass of the top quark and hence also breaks the electroweak gauge symmetry. It therefore leads to large dynamical effects within the Standard model and can partially replace the Higgs interactions.Comment: 4 pages, revtex, no figures; revised version predicting realistic mass spectru