52 research outputs found
Efecto de los polifenoles sobre la microbiota intestinal en el siÌndrome metaboÌlico
Durante los uÌltimos anÌos, el estudio de la microbiota intestinal ha surgido como un campo de investigacioÌn emergente, ya que se ha demostrado que se ve involucrada en una infinidad de procesos metaboÌlicos que repercuten en la salud del hueÌsped. En concreto, se ha visto que las personas que padecen alguna de las patologiÌas asociadas al siÌndrome metaboÌlico poseen una microbiota intestinal alterada que provoca un estado patoloÌgico denominado âdisbiosis intestinalâ. Este estado, provocado en parte por el consumo actual de dietas altas en grasa y azuÌcares y pobres en fibra, se caracteriza por una disminucioÌn de la diversidad microbiana y una alteracioÌn en su composicioÌn, y parece estar fuertemente relacionado con la aparicioÌn y desarrollo de las patologiÌas del siÌndrome metaboÌlico.
Entre las distintas estrategias descritas para modificar la microbiota intestinal alterada, se ha observado que la suplementacioÌn de la dieta con ciertos tipos de polifenoles, como el resveratrol o las antocianinas, pueden revertir la disbiosis intestinal, ayudando a la proliferacioÌn de bacterias beneficiosas para nuestro organismo, como Akkermansia muciniphila, a la vez que disminuyen la cantidad de bacterias nocivas, como las pertenecientes al filo Firmicutes y estimulando asiÌ una mayor produccioÌn de aÌcidos grasos de cadena corta, como el butirato. En este trabajo se ha llevado a cabo una revisioÌn de la bibliografiÌa disponible sobre la capacidad de diversos polifenoles (no flavonoides, flavonoles y flavanoles) de contrarrestar el efecto de una dieta occidental sobre la microbiota intestinal, revirtiendo los efectos del siÌndrome metaboÌlico, asiÌ como un estudio de los principales mecanismos implicados en este proceso.In recent years, the study of the intestinal microbiota has emerged as a field of research. Since it has been shown that it is involved in an infinite number of metabolic processes that affect the health of the host. Specifically, people suffering from any of the pathologies associated with the metabolic syndrome have an altered intestinal microbiota that causes a medical state called "intestinal dysbiosis". This state is caused partially due to current consumption of diets high in fat and sugars, and poor in fiber. Consequently, decreasing microbial diversity and altering its composition. Strongly correlating with the appearance and development of metabolic syndrome pathologies.
Among the different strategies described to modify the altered intestinal microbiota, it has been observed that dietary supplementation with certain types of polyphenols, such as resveratrol or anthocyanins can reverse intestinal dysbiosis. Therefore, promoting the proliferation of beneficial bacteria for our body, like Akkermansia muciniphila, while reducing the number of harmful bacteria such as those belonging to the Firmicutes phylum. As a result, stimulating a greater production of short chain fatty acids as butyrate. This paper reviews the available literature on various polyphenols (non-flavonoids, flavonols and flavanols) and their ability to counteract the effect of a western diet on the intestinal microbiota. Focusing on reversing the effects of the metabolic syndrome, as well as analyzing the main mechanism involved in this process
Bioactive extracts from persimmon waste: influence of extraction conditions and ripeness.
In this work, a bioactive persimmon extract was produced from discarded fruits. A central composite design was used to evaluate the effect of different extraction parameters and ripeness stages of persimmon fruits on the total phenolic content and antioxidant activity of the resulting extracts. Significantly greater phenolic contents were obtained from immature persimmon (IP) fruits. The optimum IP extract with the conditions set by the experimental design was industrially up-scaled and its composition and functional properties were evaluated and compared with those obtained under lab-scale conditions. Both extracts contained significant protein (>20%) and phenolic contents (âŒ11-27 mg GA/g dry extract) and displayed significant antiviral activity against murine norovirus and hepatitis A virus. Moreover, the extract showed no toxicity and significantly reduced the fat content and the cellular ageing of Caenorhabditis elegans (C. elegans) without affecting the worm development. These effects were mediated by down-regulation of fat-7, suggesting an anti-lipogenic activity of this extract
AnĂĄlisis de los genes C-CBL, CBL-B y CBL-C em neoplasias mieloproliferativas crĂłnicas BCR-ABL1 y V617FJAK2 negativas
FISH screening of Receptor- and Cytoplasmatic Tyrosine Kinase genes in BCR-ABL1 negative and JAK2V617F negative chronic myeloproliferative neoplasms (CMPNs)
AnĂĄlisis de la expresiĂłn diferencial de distintos transcritos de PDGFRA en neoplasias hematolĂłgicas con eosinofilia
AnĂĄlisis mediante dHPLC de la familia III de las RTKs en neoplasias mieloproliferativas crĂłnicas BCR-ABL1 negativas
Screening mediante FISH de genes codificantes de TKs en neoplasias mieloproliferativas crĂłnicas BCR-ABL1 y V617FJAK2 negativas
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