815 research outputs found
Studying and Modeling the Connection between People's Preferences and Content Sharing
People regularly share items using online social media. However, people's
decisions around sharing---who shares what to whom and why---are not well
understood. We present a user study involving 87 pairs of Facebook users to
understand how people make their sharing decisions. We find that even when
sharing to a specific individual, people's own preference for an item
(individuation) dominates over the recipient's preferences (altruism). People's
open-ended responses about how they share, however, indicate that they do try
to personalize shares based on the recipient. To explain these contrasting
results, we propose a novel process model of sharing that takes into account
people's preferences and the salience of an item. We also present encouraging
results for a sharing prediction model that incorporates both the senders' and
the recipients' preferences. These results suggest improvements to both
algorithms that support sharing in social media and to information diffusion
models.Comment: CSCW 201
Superluminous supernovae: No threat from Eta Carinae
Recently Supernova 2006gy was noted as the most luminous ever recorded, with
a total radiated energy of ~10^44 Joules. It was proposed that the progenitor
may have been a massive evolved star similar to eta Carinae, which resides in
our own galaxy at a distance of about 2.3 kpc. eta Carinae appears ready to
detonate. Although it is too distant to pose a serious threat as a normal
supernova, and given its rotation axis is unlikely to produce a Gamma-Ray Burst
oriented toward the Earth, eta Carinae is about 30,000 times nearer than
2006gy, and we re-evaluate it as a potential superluminous supernova. We find
that given the large ratio of emission in the optical to the X-ray, atmospheric
effects are negligible. Ionization of the atmosphere and concomitant ozone
depletion are unlikely to be important. Any cosmic ray effects should be spread
out over ~10^4 y, and similarly unlikely to produce any serious perturbation to
the biosphere. We also discuss a new possible effect of supernovae, endocrine
disruption induced by blue light near the peak of the optical spectrum. This is
a possibility for nearby supernovae at distances too large to be considered
"dangerous" for other reasons. However, due to reddening and extinction by the
interstellar medium, eta Carinae is unlikely to trigger such effects to any
significant degree.Comment: 19 pages, 2 figures; Revised version as accepted for publication in
Astrobiolog
A Research of nasal methicillin resistant/sensitive Staphylococcus aureus and pharyngeal beta-haemolytic Streptococcus carriage in midwifery students in Kahramanmaras, Eastern Mediterranean Region of Turkey
Background: In the hospitals where hygienic conditions are not provided, nasal methicillin resistant/sensitive Staphylococcus aureus (MRSA/MSSA) colonization is seen in the hospital personnel and patients. Both the individuals’ themselves being MRSA/MSSA carriers and also other people around them are under risk and this bacterium leads to nasal colonization and then can propagate through contaminated hands and hospital materials.Objective: In this study, it was aimed to research MRSA/MSSA and beta-haemolytic streptococcus (BHS) carriage in the nose and throat flora of students of, School of Health.Methods: In the study, total of 160 midwifery students taking midwifery education was included in the research but 135 (84.4 %) out of 160 students were able to be reached. The nose and throat swab samples taken from students were examined through microbiological methods.Results: 14.1 % of students were nasal MSSA carrier. While there wasn't the nasal MRSA carrier among students attending the study in the 1st and 2nd class, 3.3 % (1 person) of the 3rd class students and 10.0 % (3 people) of the 4th class students were the nasal MRSA carrier. In addition, BHS carriage was determined in 1.5 % of students and there wasn't any difference between classes.Conclusions: These results indicate that midwifery students might have been contaminated with MSSA/MRSA during clinical practice. That MSSA/MRSA being an important pathogen is seen in midwifery students taking education in the birth units threatens the mother-child health. [Ethiop. J. Health Dev. 2010;24(1):57-60
Efficacy of Vancomycin, Teicoplanin and Fusidic Acid as Prophylactic Agents in Prevention of Vascular Graft Infection: An Experimental Study in Rat
AbstractObjectivesTo compare the efficacy of a single prophylactic dose of intra-peritoneal vancomycin and teicoplanin with anti-biotic treated Dacron grafts (vancomycin, teicoplanin, 10 or 40% fusidic acid-soaked grafts) in preventing vascular graft infections in a rat model.DesignProspective, randomized, controlled animal study.Materials and methodsThe graft infections were established in the subcutaneous tissues of 80 female Sprague–Dawley rats by the implantation of Dacron prostheses followed by the topical inoculation with methicillin-resistant Staphylococcus aureus. The study groups were as follows: (1) uncontaminated control group, (2) untreated contaminated group, (3) contaminated group with intra-peritoneal vancomycin, (4) contaminated group with intra-peritoneal teicoplanin, (5) contaminated group received vancomycin-soaked Dacron graft, (6) contaminated group received teicoplanin-soaked Dacron graft, (7) contaminated group received 40% fusidic acid-soaked Dacron graft, and (8) contaminated group received 10% fusidic acid-soaked Dacron graft prophylaxis. The grafts were removed after 7 days and evaluated by a quantitative culture analysis.ResultsNo infection was detected in controls. The untreated contaminated group had a high bacteria count (6.0×104CFU/cm2 Dacron graft). Groups that received intra-peritoneal vancomycin or teicoplanin had less bacterial growth (4.8×103 and 3.9×103CFU/cm2 Dacron graft, respectively). Similarly, the group that received 10% fusidic acid-soaked graft showed less bacterial growth (3.6×103CFU/cm2 Dacron graft). The groups with vancomycin-, teicoplanin- and 40% fusidic acid-soaked grafts showed no evidence of infection. Statistical analyses demonstrated that intra-peritoneal prophylactic antibiotic treatment was less effective in inhibiting bacterial growth than high concentration antimicrobial-soaking of grafts.ConclusionThe use of vancomycin-, teicoplanin- and 40% fusidic acid-soaked grafts was effective in preventing primary prosthetic vascular graft infection
Cost-effectiveness of sorafenib for treatment of radioactive iodine (rai)-refractory locally advanced/metastatic differentiated thyroid cancer (dtc) in Turkey
WOS: 000354498503198OBJECTIVES: Sorafenib is the first product approved for treatment of RAI refractory locally advanced/metastatic DTC patients. This study was conducted in order to analyze cost-effectiveness of sorafenib for treatment of patients with RAI refractory locally advanced/metastatic DTC in Turkey. METHODS: A cohort partition model assigning patients to one of three health states according to the proportion of patients who are progression-free, progressed, or dead in each 28-days cycle was adapted to Turkish setting. The incremental cost-effectiveness ratios (ICER) were calculated per quality-adjusted life years (QALYs) and life-years (LYs) gained. Turkish payer’s perspective was taken and time-horizon was set as patient’s lifetime (maximum 30 years). Sorafenib was compared to the best supportive care (BSC) within the model since there are no agents for treatment of patients on this stage of the disease. Essential clinical inputs were derived from DECISION trial and local resource-utilization data were based on expert opinions through an expert panel. Sensitivity of the results was evaluated in terms of key inputs by deterministic oneway and probabilistic sensitivity analyses. All costs were calculated in Turkish Liras (TL) and converted to USD using TL/USD currency rate as 2.2 (mid-2014). RESULTS: Total cost of sorafenib-treated patients is 24,384 USD higher compared to BSC. Besides, sorafenib is associated with increments of 1.29 LYs and 0.80 QALYs compared to BSC. The ICER of sorafenib per LYs and QALYs gained compared to BSC were determined as 18,851 USD and 30,485 USD respectively. One-way sensitivity analysis demonstrated that results are not sensitive to the changes in model inputs and pharmacoeconomic analysis results were validated by probabilistic sensitivity analysis. CONCLUSIONS: Sorafenib is cost-effective for treatment of patients with RAI refractory locally advanced/metastatic DTC compared to BSC with an ICER value below the willingness-to-pay threshold (3-times GDP per capita ─ 32,346 USD) for Turkey
Individualization as driving force of clustering phenomena in humans
One of the most intriguing dynamics in biological systems is the emergence of
clustering, the self-organization into separated agglomerations of individuals.
Several theories have been developed to explain clustering in, for instance,
multi-cellular organisms, ant colonies, bee hives, flocks of birds, schools of
fish, and animal herds. A persistent puzzle, however, is clustering of opinions
in human populations. The puzzle is particularly pressing if opinions vary
continuously, such as the degree to which citizens are in favor of or against a
vaccination program. Existing opinion formation models suggest that
"monoculture" is unavoidable in the long run, unless subsets of the population
are perfectly separated from each other. Yet, social diversity is a robust
empirical phenomenon, although perfect separation is hardly possible in an
increasingly connected world. Considering randomness did not overcome the
theoretical shortcomings so far. Small perturbations of individual opinions
trigger social influence cascades that inevitably lead to monoculture, while
larger noise disrupts opinion clusters and results in rampant individualism
without any social structure. Our solution of the puzzle builds on recent
empirical research, combining the integrative tendencies of social influence
with the disintegrative effects of individualization. A key element of the new
computational model is an adaptive kind of noise. We conduct simulation
experiments to demonstrate that with this kind of noise, a third phase besides
individualism and monoculture becomes possible, characterized by the formation
of metastable clusters with diversity between and consensus within clusters.
When clusters are small, individualization tendencies are too weak to prohibit
a fusion of clusters. When clusters grow too large, however, individualization
increases in strength, which promotes their splitting.Comment: 12 pages, 4 figure
Investigation of intermediary margins in the marketing of beef and lamb meat in ankara province, turkey
Cognitive testing of an instrument to evaluate acceptability and use of pre-exposure prophylaxis products among women
Given the range of pre-exposure prophylaxis (PrEP) products currently being tested to prevent HIV in women, a standardized Acceptability and Use of PrEP Products Among Women Tool may facilitate comparisons of product acceptability and use across different geographies, trials, and users. We conducted three rounds of cognitive interviewing over 2 months in 2016, with 28 South African women who had experience participating in a range of PrEP product trials. The final instrument contained 41 items, including five new items that improved construct validity and 22 items modified for clarity. Changes were made due to unclear wording, difficulty answering, participant embarrassment, low response variability, and administrative formatting. Cognitive interviewing provided a means to address issues that would have inhibited this tool's ability to accurately collect data otherwise. This rapid, low-cost study provided valuable insight into participants' understanding of questions and demonstrated the utility of cognitive interviewing in international clinical trials
Dynamics in online social networks
An increasing number of today's social interactions occurs using online
social media as communication channels. Some online social networks have become
extremely popular in the last decade. They differ among themselves in the
character of the service they provide to online users. For instance, Facebook
can be seen mainly as a platform for keeping in touch with close friends and
relatives, Twitter is used to propagate and receive news, LinkedIn facilitates
the maintenance of professional contacts, Flickr gathers amateurs and
professionals of photography, etc. Albeit different, all these online platforms
share an ingredient that pervades all their applications. There exists an
underlying social network that allows their users to keep in touch with each
other and helps to engage them in common activities or interactions leading to
a better fulfillment of the service's purposes. This is the reason why these
platforms share a good number of functionalities, e.g., personal communication
channels, broadcasted status updates, easy one-step information sharing, news
feeds exposing broadcasted content, etc. As a result, online social networks
are an interesting field to study an online social behavior that seems to be
generic among the different online services. Since at the bottom of these
services lays a network of declared relations and the basic interactions in
these platforms tend to be pairwise, a natural methodology for studying these
systems is provided by network science. In this chapter we describe some of the
results of research studies on the structure, dynamics and social activity in
online social networks. We present them in the interdisciplinary context of
network science, sociological studies and computer science.Comment: 17 pages, 4 figures, book chapte
- …