5 research outputs found

    Rossini round trip. Un petit train de plaisir by Azio Corghi

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    The ballet Un petit train de plaisir for two pianos and percussion by Azio Corghi is based on pieces for piano contained in Gioachino Rossini’s Pechés de vieillesse, and was performed for the first time at the Rossini Opera Festival in 1992. The comparison with the Rossini texts, that Corghi puts into effect in his compositional work, seems to configure an eccentric position both with respect to the keywords of musical aesthetics that were for a long hegemonic in the second half of the twentieth century, and with respect to the ‘post-modern’ opening that also affected music from the early seventies. Processes of sound amplification and timbre differentiation articulate a sympathetic relationship with the author of the paratexts. A relationship that takes the form of an irony understood as doubling, in which what is said tends to mean something other than what appears.The ballet Un petit train de plaisir for two pianos and percussion by Azio Corghi is based on pieces for piano contained in Gioachino Rossini’s Pechés de vieillesse, and was performed for the first time at the Rossini Opera Festival in 1992. The comparison with the Rossini texts, that Corghi puts into effect in his compositional work, seems to configure an eccentric position both with respect to the keywords of musical aesthetics that were for a long hegemonic in the second half of the twentieth century, and with respect to the ‘post-modern’ opening that also affected music from the early seventies. Processes of sound amplification and timbre differentiation articulate a sympathetic relationship with the author of the paratexts. A relationship that takes the form of an irony understood as doubling, in which what is said tends to mean something other than what appears

    One week of levofloxacin plus dexamethasone eye drops for cataract surgery: an innovative and rational therapeutic strategy

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    Background: Cataract surgery is the most common operation performed worldwide. A fixed topical corticosteroid-antibiotic combination is usually prescribed in clinical practice for 2 or more weeks to treat post surgical inflammation and prevent infection. However, this protracted schedule may increase the incidence of corticosteroid-related adverse events and notably promote antibiotic resistance. Methods: This International, multicentre, randomized, blinded-assessor, parallel-group clinical study evaluated the non-inferiority of 1-week levofloxacin/dexamethasone eye drops, followed by 1-week dexamethasone alone, vs. 2-week gold-standard tobramycin/dexamethasone (one drop QID for all schedules) to prevent and treat ocular inflammation and prevent infection after uncomplicated cataract surgery. Non-inferiority was defined as the lower limit of the 95% confidence interval (CI) around a treatment difference >-10%. The study randomized 808 patients enrolled in 53 centres (Italy, Germany, Spain and Russia). The primary endpoint was the proportion of patients without anterior chamber inflammation on day 15 defined as the end of treatment. Endophthalmitis was the key secondary endpoint. This study is registered with EudraCT code: 2018-000286-36. Results: After the end of treatment, 95.2% of the patients in the test arm vs. 94.9% of the control arm had no signs of inflammation in the anterior chamber (difference between proportions of patients = 0.028; 95% CI: -0.0275/0.0331). No case of endophthalmitis was reported. No statistically significant difference was evident in any of the other secondary endpoints. Both treatments were well tolerated. Conclusions: Non-inferiority of the new short pharmacological strategy was proven. One week of levofloxacin/dexamethasone prevents infection, ensures complete control of inflammation in almost all patients and may contain antibiotic resistance
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