SERIMI: Class-Based Matching for Instance Matching Across Heterogeneous Datasets

State-of-the-art instance matching approaches do not perform well when used for matching instances across heterogeneous datasets. This shortcoming derives from their core operation depending on direct matching, which involves a direct comparison of instances in the source with instances in the target dataset. Direct matching is not suitable when the overlap between the datasets is small. Aiming at resolving this problem, we propose a new paradigm called class-based matching. Given a class of instances from the source dataset, called the class of interest, and a set of candidate matches retrieved from the target, class-based matching refines the candidates by filtering out those that do not belong to the class of interest. For this refinement, only data in the target is used, i.e., no direct comparison between source and target is involved. Based on extensive experiments using public benchmarks, we show our approach greatly improves the quality of state-of-the-art systems; especially on difficult matching tasks

CWI at TREC 2012, KBA track and Session Track

We participated in two tracks: Knowledge Base Acceleration (KBA) Track and Session Track. In the KBA track, we focused on experi- menting with different approaches as it is the first time the track is launched. We experimented with supervised and unsupervised re- trieval models. Our supervised approach models include language models and a string-learning system. Our unsupervised approaches include using: 1)DBpedia labels and 2) Google-Cross-Lingual Dic- tionary (GCLD). While the approach that uses GCLD targets the central and relvant bins, all the rest target the central bin. The GCLD and the string-learning system have outperformed the oth- ers in their respective targeted bins. The goal of the Session track submission is to evaluate whether and how a logic framework for representing user interactions with an IR system can be used for improving the approximation of the relevant term distribution that another system that is supposed to have access to the session infor- mation will then calculate. the documents in the stream corpora. Three out of the seven runs used a Hadoop cluster provide by Sara.nl to process the stream cor- pora. The other 4 runs used a federated access to the same corpora distributed among 7 workstations

New In Vitro studies on the bioprofile of Genista tenera antihyperglycemic extract

The inhibition of a-glucosidase and glucose-6-phosphatase, two enzymes involved in the carbohydrate metabolism, is an important target to control glycaemia on individuals with type 2 diabetes. In this work we report for the first time the inhibition of both enzymes by the antihyperglycemic n-butanol extract from Genista tenera (Fabaceae). This extract decreased a-glucosidase and glucose-6-phosphatase activities to 0.97 and 80.25 %, respectively, being more effective than acarbose, and phlorizin, the positive controls, which reduced enzymes activities only to 17.39 and 96.06 %. Once inflammation and oxidative stress are related to diabetic impairments, the anti-inflammatory activity of the extract was also evaluated, through its inhibitory activity over COX-1 enzyme (47.5 % inhibition). Moreover, after induction of oxidative stress by UV radiation, the viability of irradiated rat liver hepatoma cells exposed to the extract was significantly higher (67.82 %) than that promoted by ascorbic acid, the positive control (45.05 %). In addition, the stability of the extract under gastrointestinal conditions was evaluated by HPLC–DAD-ESI–MS/MS. Flavonoid diglycosides were identified as the main constituents of the extract, and no alterations in the chemical composition nor in the antioxidant activity were observed after in vitro digestion with artificial gastric and pancreatic juices.Fundação para a Ciência e a Tecnologia e Comissão Europeiainfo:eu-repo/semantics/publishedVersio

Facile synthesis of oxo-/thioxopyrimidines and tetrazoles C–C linked to sugars as novel non-toxic antioxidant acetylcholinesterase inhibitors

Microwave-assisted synthesis of oxo-/thioxopyrimidines and tetrazoles linked to furanoses with D-xylo and D-ribo configuration, and to a D-galacto pyranose is reported and compared to conventional methods. Reaction of dialdofuranoses and dialdopyranoses with a b-keto ester and urea or thiourea under micro wave irradiation at 300 W gave in 10 min the target molecules containing the 2-oxo- or 2-thioxo-pyrimidine ring in high yield. The tetrazole-derived compounds were obtained in two steps by reaction of the formyl group with hydroxylamine hydrochloride, copper sulfate, triethylamine and dicyclohexylcarbodiimide to give an intermediate nitrile, which was then treated with sodium azide. The use of microwave irradiation in the latter step also resulted in a considerably shorter reaction time (10 min) compared to hours under conventional heating to obtain a complete starting materials conversion. Acetylcholinesterase inhibition ranged from 20% to 80% for compounds concentration of 100 lg/mL, demonstrating the potential of this family of compounds for the control of Alzheimer’s disease symptoms. Most of the compounds showed antioxidant activity in the b-carotene/linoleic acid assay, some of them exhibiting IC50 values in the same order of magnitude as those of gallic acid. The bioactive compounds did not show cytotoxic effects to human lymphocytes using the MTT method adapted for non-adherent cells, nor geno toxicity determined by the short-term in vitro chromosomal aberration assay.info:eu-repo/semantics/publishedVersio

What a difference a methyl group makes-probing choline-urea molecular interactions through urea structure modification

There is a lack of fundamental knowledge on deep eutectic solvents, even for the most extensively studied mixtures, such as the mixture of cholinium chloride and urea, which prevents a judicious choice of components to prepare new solvents. The objective of this work is to study and understand the fundamental interactions between cholinium chloride and urea that lead to the experimentally observed melting temperature depression. To do so, the structure of urea was strategically and progressively modified, in order to block certain interaction centres, and the solid–liquid equilibrium data of each new binary system was experimentally measured. Using this approach, it was concluded that the most important interaction between cholinium chloride and urea occurs through hydrogen bonding between the chloride anion and the amine groups. Any blockage of these groups severely hampers the melting point depression effect. Raman spectroscopy and DFT calculations were utilized to study in more detail this hydrogen bonding and its nuances.This work was developed in the scope of the project CICECO – Aveiro Institute of Materials, POCI-01-0145-FEDER-007679 (Ref. FCT UID/CTM/50011/2019) and Associate Laboratory LSRELCM, POCI-01-0145-FEDER-006984 (Ref. FCT UID/EQU/50020/2019), and project MultiBiorefinery (POCI-01-0145-FEDER-016403), all financed by national funds through the FCT/ MCTES (PIDDAC) and when appropriate co-financed by FEDER under the PT2020 Partnership Agreement. M. A. R. M. acknowledges financial support from NORTE-01-0145-FEDER-000006 – funded by NORTE2020 through PT2020 and ERDF. L. P. S. acknowledges FCT for her PhD grant (SFRH/BD/135976/2018). C. F. A. acknowledges FCT for her PhD grant (SFRH/BD/129040/2017). M. M. N. and M. M. F. acknowledge FCT for their researcher contracts (IF/01468/2015 and IF/00894/2015 respectively) under the program IF 2015.info:eu-repo/semantics/publishedVersio

Response of an Afro-Palearctic bird migrant to glaciation cycles

We combine tracks of a long-distance migratory bird with high–temporal resolution climate data to reconstruct habitat availability month by month for the past 120,000 y. The seasonal changes of suitable habitat in the past imply that continued seasonal migration was necessary during the glacial maxima. Genomic-based estimates of effective population size indicate that more generally migratory lifestyles can be beneficially adapted to various climatic conditions. Our results provide a major step forward in understanding how migratory species will fare in the future and have important implications for how we understand the role of migration in the distribution of species and potentially speciation