11 research outputs found
A test for comparing conditional ROC curves with multidimensional covariates
Full text linkThe comparison of Receiver Operating Characteristic (ROC) curves is
frequently used in the literature to compare the discriminatory capability of
different classification procedures based on diagnostic variables. The
performance of these variables can be sometimes influenced by the presence of
other covariates, and thus they should be taken into account when making the
comparison. A new non-parametric test is proposed here for testing the equality
of two or more dependent ROC curves conditioned to the value of a
multidimensional covariate. Projections are used for transforming the problem
into a one-dimensional approach easier to handle. Simulations are carried out
to study the practical performance of the new methodology. A real data set of
patients with Pleural Effusion is analysed to illustrate this procedure
Aggregation as bacterial inclusion bodies does not imply inactivation of enzymes and fluorescent proteins
Get PDFBACKGROUND: Many enzymes of industrial interest are not in the market since they are bio-produced as bacterial inclusion bodies, believed to be biologically inert aggregates of insoluble protein. RESULTS: By using two structurally and functionally different model enzymes and two fluorescent proteins we show that physiological aggregation in bacteria might only result in a moderate loss of biological activity and that inclusion bodies can be used in reaction mixtures for efficient catalysis. CONCLUSION: This observation offers promising possibilities for the exploration of inclusion bodies as catalysts for industrial purposes, without any previous protein-refolding step
Las emociones en el profesorado: el afecto y el enfado como recursos para el disciplinamiento
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Pericarditis aguda recidivante asociada a enfermedad de Still del adulto tratada con pericardiectomía
No full textAggregation as bacterial inclusion bodies does not imply inactivation of enzymes and fluorescent proteins
No full textBackground: Many enzymes of industrial interest are not in the market since they are bio-produced as bacterial inclusion bodies, believed to be biologically inert aggregates of insoluble protein. Results: By using two structurally and functionally different model enzymes and two fluorescent proteins we show that physiological aggregation in bacteria might only result in a moderate loss of biological activity and that inclusion bodies can be used in reaction mixtures for efficient catalysis. Conclusion: This observation offers promising possibilities for the exploration of inclusion bodies as catalysts for industrial purposes, without any previous protein-refolding step
El Burnout y las variables sociodemográficas en los profesionales de la educación que trabajan con personas con discapacidad en Córdoba (España)
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