Walking along roads, building the path

“Equidad y Orientación: el desafío del seguimiento de los jóvenes egresados” constituye una estrategia de acompañamiento pos egreso del nivel secundario para jóvenes que participaron en el año anterior del Programa “Equidad y Orientación el Desafío de una propuesta”. Ambos programas se implementan a través del Convenio de Cooperación Interinstitucional entre la UNLP/Facultad de Psicología y la Fundación Florencio Pérez desde el año 2010. Asimismo, constituyen acciones de transferencia de Proyectos de Investigación de la Cátedra de Orientación Vocacional realizados en años anteriores y actualmente aportan al proyecto de investigación en curso, denominado “Evaluación de Estrategias de Inclusión para disminuir el abandono universitario y la reorientación en otros ámbitos educativos-formativos” (2014-2017) acreditado y subsidiado por la SeCyT. El objetivo general de este programa es lograr que los alumnos que participaron en las escuelas del ciclo lectivo 2014, Escuela Media 13 y Escuela Secundaria 15 de La Plata, puedan concretar los proyectos educativos, laborales, personales y/o sociales elaborados en la propuesta Equidad y Orientación: el desafío de una propuesta.The purpose of this paper is to outline the work performed in the project "Equity and Guidance: the challenge of monitoring newly graduated pupils". This project is part of a larger programme called "Equity and Guidance: A Proposal Challenge" which was carried out in 2014 with students attending their last year, in two different public secondary schools in La Plata: Escuela Media n° 13 and Escuela Media n° 15. The purpose of this programme is to help students accomplish their educational, emotional, personal, social and work life goals.Trabajos libres: Orientación vocacional y ocupacionalFacultad de Psicologí

Alumbrándonos: hacia estrategias orientadoras

El presente trabajo, expone la tarea desarrollada en el programa “Equidad y Orientación: el desafío del seguimiento de los jóvenes egresados”. El mismo es una prolongación del Programa “Equidad y Orientación el Desafío de una propuesta” desarrollado en el año 2014 con alumnos del último año de dos escuelas secundarias públicas de la ciudad de La Plata: Escuela Media N° 13 y Escuela Media N°15. El objetivo es que los alumnos puedan concretar los proyectos educativos, laborales, personales y/o sociales que se han decidido llevar adelante. El seguimiento es un trabajo llevado acabo por un grupo de profesionales de Psicología, que nos ofrecemos a acompañarlos, ayudarlos y orientarlos en los diferentes recorridos que han empezado a transitar en su primer año fuera de la institución escolar. La metodología que se utiliza para mantener, continuar y reforzar la comunicación con los jóvenes es de orden cualitativo, mediante diversas vías de comunicación. Los resultados reflejados en dicho trabajo son los obtenidos durante el desarrollo del 2015.Facultad de Psicologí

Solid Organ Transplantation During COVID-19 Pandemic: An International Web-based Survey on Resources’ Allocation

Background. Solid organ transplants (SOTs) are life-saving interventions, recently challenged by coronavirus disease 2019 (COVID-19). SOTs require a multistep process, which can be affected by COVID-19 at several phases. Methods. SOT-specialists, COVID-19-specialists, and medical ethicists designed an international survey according to CHERRIES guidelines. Personal opinions about continuing SOTs, safe managing of donors and recipients, as well as equity of resources' allocation were investigated. The survey was sent by e-mail. Multiple approaches were used (corresponding authors from Scopus, websites of scientific societies, COVID-19 webinars). After the descriptive analysis, univariate and multivariate ordinal regression analysis was performed. Results. There were 1819 complete answers from 71 countries. The response rate was 49%. Data were stratified according to region, macrospecialty, and organ of interest. Answers were analyzed using univariate- multivariate ordinal regression analysis and thematic analysis. Overall, 20% of the responders thought SOTs should not stop (continue transplant without restriction); over 70% suggested SOTs should selectively stop, and almost 10% indicated they should completely stop. Furthermore, 82% agreed to shift resources from transplant to COVID-19 temporarily. Briefly, main reason for not stopping was that if the transplant will not proceed, the organ will be wasted. Focusing on SOT from living donors, 61% stated that activity should be restricted only to "urgent"cases. At the multivariate analysis, factors identified in favor of continuing transplant were Italy, ethicist, partially disagreeing on the equity question, a high number of COVID-19- related deaths on the day of the answer, a high IHDI country. Factors predicting to stop SOTs were Europe except-Italy, public university hospital, and strongly agreeing on the equity question. Conclusions. In conclusion, the majority of responders suggested that transplant activity should be continued through the implementation of isolation measures and the adoption of the COVID-19-free pathways. Differences between professional categories are less strong than supposed

Walking along roads, building the path

“Equidad y Orientación: el desafío del seguimiento de los jóvenes egresados” constituye una estrategia de acompañamiento pos egreso del nivel secundario para jóvenes que participaron en el año anterior del Programa “Equidad y Orientación el Desafío de una propuesta”. Ambos programas se implementan a través del Convenio de Cooperación Interinstitucional entre la UNLP/Facultad de Psicología y la Fundación Florencio Pérez desde el año 2010. Asimismo, constituyen acciones de transferencia de Proyectos de Investigación de la Cátedra de Orientación Vocacional realizados en años anteriores y actualmente aportan al proyecto de investigación en curso, denominado “Evaluación de Estrategias de Inclusión para disminuir el abandono universitario y la reorientación en otros ámbitos educativos-formativos” (2014-2017) acreditado y subsidiado por la SeCyT. El objetivo general de este programa es lograr que los alumnos que participaron en las escuelas del ciclo lectivo 2014, Escuela Media 13 y Escuela Secundaria 15 de La Plata, puedan concretar los proyectos educativos, laborales, personales y/o sociales elaborados en la propuesta Equidad y Orientación: el desafío de una propuesta.The purpose of this paper is to outline the work performed in the project "Equity and Guidance: the challenge of monitoring newly graduated pupils". This project is part of a larger programme called "Equity and Guidance: A Proposal Challenge" which was carried out in 2014 with students attending their last year, in two different public secondary schools in La Plata: Escuela Media n° 13 and Escuela Media n° 15. The purpose of this programme is to help students accomplish their educational, emotional, personal, social and work life goals.Trabajos libres: Orientación vocacional y ocupacionalFacultad de Psicologí

Differential Response of Dopamine Mediated by β-Adrenergic Receptors in Human Keratinocytes and Macrophages: Potential Implication in Wound Healing

Objective: Dopamine is an immunomodulatory neurotransmitter. In the skin, keratinocytes and macrophages produce proinflammatory cytokines and metalloproteinases (MMPs) which participate in wound healing. These cells have a catecholaminergic system that modulates skin pathophysiologic processes. We have demonstrated that dopamine modulates cytokine production in keratinocytes via dopaminergic and adrenergic receptors (ARs). The aim of this study was to evaluate the effect of dopamine and its interaction with β-ARs in human HaCaT keratinocytes and THP-1 macrophages. We evaluated the production of inflammatory mediators implicated in wound healing. Methods: Cells were stimulated with dopamine in the absence or presence of the β-adrenergic antagonist propranolol. Wound closure, MMP activity, and the production of IL-8, IL-1β, and IκB/NFκB pathway activation were determined in stimulated cells. Results: Dopamine did not affect the wound closure in human keratinocytes, but diminished the propranolol stimulatory effect, thus delaying cell migration. Similarly, dopamine significantly decreased MMP-9 activity and the propranolol-induced MMP activity. Dopamine significantly increased the p65-NFκB subunit levels in the nuclear extracts, which were reduced in the presence of propranolol in keratinocytes. On the other hand, dopamine significantly increased MMP-9 activity in THP-1 macrophages, but did not modify the propranolol-increased enzymatic activity. Dopamine significantly increased IL-8 production in human macrophages, an effect that was partially reduced by propranolol. Dopamine did not modify the p65-NFκB levels in the nuclear extracts in THP-1 macrophages. Conclusion: We suggest that the effect of dopamine via β-ARs depends on the physiological condition and the cell type involved, thus contributing to either improve or interfere with the healing process.Fil: Parrado, Andrea Cecilia. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Estudios de la Inmunidad Humoral Prof. Ricardo A. Margni. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Estudios de la Inmunidad Humoral Prof. Ricardo A. Margni; ArgentinaFil: Salaverry, Luciana Soledad. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Estudios de la Inmunidad Humoral Prof. Ricardo A. Margni. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Estudios de la Inmunidad Humoral Prof. Ricardo A. Margni; ArgentinaFil: Mangone, Franco Mauricio. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Estudios de la Inmunidad Humoral Prof. Ricardo A. Margni. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Estudios de la Inmunidad Humoral Prof. Ricardo A. Margni; ArgentinaFil: Apicella, Carolina Eugenia. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica; ArgentinaFil: Gentile, Maria Teresa. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica; ArgentinaFil: Canellada, Andrea Mercedes. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Estudios de la Inmunidad Humoral Prof. Ricardo A. Margni. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Estudios de la Inmunidad Humoral Prof. Ricardo A. Margni; ArgentinaFil: Rey, Estela Beatriz. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Estudios de la Inmunidad Humoral Prof. Ricardo A. Margni. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Estudios de la Inmunidad Humoral Prof. Ricardo A. Margni; Argentin

Combined modality therapy for thoracic and head and neck cancers: a review of updated literature based on a consensus meeting

Combined modality therapy is a mainstay option for thoracic malignancies and head and neck cancers. The integration of different strategies is based on the multidisciplinary approach of modern clinical oncology. Radiation oncologists have to be educated, trained, and updated to provide state-of-the-art care to cancer patients and thus educational meetings are crucial

Philadelphia-like acute lymphoblastic leukemia is associated with minimal residual disease persistence and poor outcome. First report of the minimal residual disease-oriented GIMEMA LAL1913

Early recognition of Philadelphia-like (Ph-like) acute lymphoblastic leukemia (ALL) cases could impact on the management and outcome of this subset of B-lineage ALL. In order to assess the prognostic value of the Ph-like status in a pediatric-inspired, minimal residual disease (MRD)-driven trial, we screened 88 B-lineage ALL cases negative for major fusion genes (BCR-ABL1, ETV6-RUNX1, TCF3-PBX1 and KTM2Ar) enrolled in the GIMEMA LAL1913 front-line protocol for adult BCR/ABL1-negative ALL. The screening - performed using the "BCR/ABL1-like predictor" - identified 28 Ph-like cases (31.8%), characterized by CRLF2 overexpression (35.7%), JAK/STAT pathway mutations (33.3%), IKZF1 (63.6%), BTG1 (50%) and EBF1 (27.3%) deletions, and rearrangements targeting tyrosine kinases or CRLF2 (40%). The correlation with outcome highlighted that: i) the complete remission rate was significantly lower in Ph-like compared to non-Phlike cases (74.1% vs. 91.5%, P=0.044); ii) at time point 2, decisional for transplant allocation, 52.9% of Ph-like cases versus 20% of non-Ph-like were MRD-positive (P=0.025); iii) the Ph-like profile was the only parameter associated with a higher risk of being MRD-positive at time point 2 (P=0.014); iv) at 24 months, Ph-like patients had a significantly inferior event-free and disease-free survival compared to non-Ph-like patients (33.5% vs. 66.2%, P=0.005 and 45.5% vs. 72.3%, P=0.062, respectively). This study documents that Ph-like patients have a lower complete remission rate, event-free survival and disease-free survival, as well as a greater MRD persistence also in a pediatric-oriented and MRD-driven adult ALL protocol, thus reinforcing that the early recognition of Ph-like ALL patients at diagnosis is crucial to refine risk-stratification and to optimize therapeutic strategies. Clinicaltrials gov. Identifier: 02067143