136 research outputs found

    Situational analysis of socio-cultural interaction of states under conditions of globalization

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    The present article considers the possibilities of the paradigm of socio-cultural interaction when analyzing international relations. Traditional activity approaches in explaining this interaction are critically assessed, and the main situations of interstate interactions that have a socio-cultural importance are analyzed. The offered problematisation when studying global strategies of interstate relations in terms of socio-cultural interaction makes it possible to consider desirable strategies and scenarios for improving intercultural communication and international cooperation. Possible prospects on changing the basic benchmarks of the globalization processes based on socio-cultural interaction for its further humanization are outlined. The revealed mechanisms of the dynamics of socio-cultural interactions when moving from one situation of interaction to another, as well as the role of the cultural reality formed for this purpose and overcoming the one-sidedness of economism in international relations can provoke the researchers’ interest. The offered analysis of the situations of socio-cultural interaction enables the authors of the article to clarify some positive opportunities of the globalization in the overall civilization development and intercultural dialogue of all countries of the world community. The results given in the article in relation to studying the main reasons of the discrimination in interstate relations and offers on overcoming it by using the spiritual and moral potential of the world culture are also of great importance.peer-reviewe

    NMR screening of potential inhibitors of methionine Ξ³-lyase from Citrobacter freundii

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    Β© 2014, Pleiades Publishing, Inc. Methionine Ξ³-lyase [EC 4.4.1.11] participates in methionine catabolism in a number of bacteria and protozoa eukaryotes, including pathogenic microorganisms. The lack of this enzyme in mammals allows us consider it to be a promising target for rational antibacterial drug design. Currently, in medical practice, there are no preparations based on the inhibition of methionine Ξ³-lyase. We present the results of a search for potential inhibitors of this enzyme using NMR screening techniques based on the identification of compounds, which are able to bind specifically to their biological target. The study included a stage of in silico virtual screening of the library of commercially available compounds and subsequent experimental selection of the leading compounds capable to interact with the enzyme. The identification of binding was carried out using saturation transfer difference (STD) spectroscopy and the WaterLOGSY technique. During the final stage, an experimental assessment of the inhibition activity of the selected compounds in the reaction of the Ξ³ elimination of L-methionine catalyzed by methionine Ξ³-lyase was performed. Binding constants of two leading compounds were determined using the WaterLOGSY method. This study expands the structural group of potential inhibitors of methionine Ξ³-lyase and allows us to approach the design of its inhibitors with higher efficacy

    INTRODUCTION OF INTERACTIVE HEALTH-SAVING TECHNOLOGIES FOR STUDENTS OF COLLEGES

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    The article presents the testing of personalized interactive preventive technologies for adolescents, college students in Yekaterinburg.Π’ ΡΡ‚Π°Ρ‚ΡŒΠ΅ прСдставлСна апробация пСрсонализированных ΠΈΠ½Ρ‚Π΅Ρ€Π°ΠΊΡ‚ΠΈΠ²Π½Ρ‹Ρ… профилактичСских Ρ‚Π΅Ρ…Π½ΠΎΠ»ΠΎΠ³ΠΈΠΉ для подростков, учащихся ΠΊΠΎΠ»Π»Π΅Π΄ΠΆΠ΅ΠΉ Π³. Π•ΠΊΠ°Ρ‚Π΅Ρ€ΠΈΠ½Π±ΡƒΡ€Π³

    Monitoring behavioral risk factors and formation of health saving behavior in adolescents

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    The article shows the results of a comparative assessment of the health-saving behavior in adolescents studying in schools and colleges of the Sverdlovsk region according to monitoring data of 2009-2018Π’ ΡΡ‚Π°Ρ‚ΡŒΠ΅ ΠΏΡ€ΠΈΠ²Π΅Π΄Π΅Π½Ρ‹ Ρ€Π΅Π·ΡƒΠ»ΡŒΡ‚Π°Ρ‚Ρ‹ ΡΡ€Π°Π²Π½ΠΈΡ‚Π΅Π»ΡŒΠ½ΠΎΠΉ ΠΎΡ†Π΅Π½ΠΊΠΈ Π·Π΄ΠΎΡ€ΠΎΠ²ΡŒΠ΅ ΡΠ±Π΅Ρ€Π΅Π³Π°ΡŽΡ‰Π΅Π³ΠΎ повСдСния подростков, ΠΎΠ±ΡƒΡ‡Π°ΡŽΡ‰ΠΈΡ…ΡΡ Π² ΡˆΠΊΠΎΠ»Π°Ρ… ΠΈ ΠΊΠΎΠ»Π»Π΅Π΄ΠΆΠ°Ρ… БвСрдловской области ΠΏΠΎ Π΄Π°Π½Π½Ρ‹ΠΌ ΠΌΠΎΠ½ΠΈΡ‚ΠΎΡ€ΠΈΠ½Π³Π° 2009-2018 Π³Π³

    Testing Social Impact Projects in the Healthcare Sector to Improve Public Health and Quality of Life for Children

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    Considering the reduction in the child population, children’s health status is an urgent medical and social problem. According to experts from the World Health Organisation, the growing burden of obesity and other non-communicable diseases has become a new threat to children’s health. In most cases, obesity in children is due to manageable risk factors and is a preventable disease. Currently, there are no comprehensive long-term programmes aimed at preventing childhood obesity in Russia. In view of the absence of tariffs for the provision of preventive medical services in the framework of compulsory medical insurance, this medical care is not provided to children β€œfree of charge” under the Program of State Guarantees of Free Medical Care to Citizens. In conditions of a shortage of financial resources, the state cannot fully fulfil the function of protecting the health of the child population. In such circumstances, the involvement of business in solving social issues is practiced in many countries. Social impact bonds are one of the financial instruments. Testing of programmes for the prevention of obesity in children in Sverdlovsk oblast can be implemented as part of a social impact project.Π’ условиях сокращСния числСнности дСтского насСлСния состояниС Π·Π΄ΠΎΡ€ΠΎΠ²ΡŒΡ Π΄Π΅Ρ‚Π΅ΠΉ прСдставляСт собой Π°ΠΊΡ‚ΡƒΠ°Π»ΡŒΠ½ΡƒΡŽ ΠΌΠ΅Π΄ΠΈΠΊΠΎ-ΡΠΎΡ†ΠΈΠ°Π»ΡŒΠ½ΡƒΡŽ ΠΏΡ€ΠΎΠ±Π»Π΅ΠΌΡƒ. По мнСнию экспСртов ВсСмирной ΠΎΡ€Π³Π°Π½ΠΈΠ·Π°Ρ†ΠΈΠΈ здравоохранСния, Π½ΠΎΠ²ΠΎΠΉ ΡƒΠ³Ρ€ΠΎΠ·ΠΎΠΉ Π·Π΄ΠΎΡ€ΠΎΠ²ΡŒΡŽ Π΄Π΅Ρ‚Π΅ΠΉ стало растущСС брСмя оТирСния ΠΈ Π΄Ρ€ΡƒΠ³ΠΈΡ… Π½Π΅ΠΈΠ½Ρ„Π΅ΠΊΡ†ΠΈΠΎΠ½Π½Ρ‹Ρ… Π·Π°Π±ΠΎΠ»Π΅Π²Π°Π½ΠΈΠΉ. Π’ Π±ΠΎΠ»ΡŒΡˆΠΈΠ½ΡΡ‚Π²Π΅ случаСв ΠΎΠΆΠΈΡ€Π΅Π½ΠΈΠ΅ Ρƒ Π΄Π΅Ρ‚Π΅ΠΉ обусловлСно управляСмыми Ρ„Π°ΠΊΡ‚ΠΎΡ€Π°ΠΌΠΈ риска ΠΈ относится ΠΊ числу ΠΏΡ€Π΅Π΄ΠΎΡ‚Π²Ρ€Π°Ρ‚ΠΈΠΌΡ‹Ρ… Π·Π°Π±ΠΎΠ»Π΅Π²Π°Π½ΠΈΠΉ. Π’ настоящСС врСмя Π² России ΠΎΡ‚ΡΡƒΡ‚ΡΡ‚Π²ΡƒΡŽΡ‚ комплСксныС долгосрочныС ΠΏΡ€ΠΎΠ³Ρ€Π°ΠΌΠΌΡ‹, Π½Π°ΠΏΡ€Π°Π²Π»Π΅Π½Π½Ρ‹Π΅ Π½Π° ΠΏΡ€ΠΎΡ„ΠΈΠ»Π°ΠΊΡ‚ΠΈΠΊΡƒ дСтского оТирСния. Π’Π²ΠΈΠ΄Ρƒ отсутствия Ρ‚Π°Ρ€ΠΈΡ„ΠΎΠ² Π½Π° ΠΎΠΊΠ°Π·Π°Π½ΠΈΠ΅ профилактичСских мСдицинских услуг Π² Ρ€Π°ΠΌΠΊΠ°Ρ… ΠΎΠ±ΡΠ·Π°Ρ‚Π΅Π»ΡŒΠ½ΠΎΠ³ΠΎ мСдицинского страхования данная мСдицинская ΠΏΠΎΠΌΠΎΡ‰ΡŒ Π½Π΅ оказываСтся дСтям «бСсплатно» Π² Ρ€Π°ΠΌΠΊΠ°Ρ… ΠŸΡ€ΠΎΠ³Ρ€Π°ΠΌΠΌΡ‹ государствСнных Π³Π°Ρ€Π°Π½Ρ‚ΠΈΠΉ бСсплатного оказания Π³Ρ€Π°ΠΆΠ΄Π°Π½Π°ΠΌ мСдицинской ΠΏΠΎΠΌΠΎΡ‰ΠΈ. БкладываСтся ситуация, ΠΊΠΎΠ³Π΄Π° Π² условиях Π΄Π΅Ρ„ΠΈΡ†ΠΈΡ‚Π° финансовых срСдств государство Π½Π΅ ΠΌΠΎΠΆΠ΅Ρ‚ ΠΏΠΎΠ»Π½ΠΎΡ†Π΅Π½Π½ΠΎ Π²Ρ‹ΠΏΠΎΠ»Π½ΡΡ‚ΡŒ Ρ„ΡƒΠ½ΠΊΡ†ΠΈΡŽ ΠΎΡ…Ρ€Π°Π½Ρ‹ Π·Π΄ΠΎΡ€ΠΎΠ²ΡŒΡ дСтского насСлСния. Π’ Ρ‚Π°ΠΊΠΈΡ… условиях ΠΏΡ€ΠΈΠ²Π»Π΅Ρ‡Π΅Π½ΠΈΠ΅ бизнСса ΠΊ Ρ€Π΅ΡˆΠ΅Π½ΠΈΡŽ ΡΠΎΡ†ΠΈΠ°Π»ΡŒΠ½Ρ‹Ρ… вопросов практикуСтся Π²ΠΎ ΠΌΠ½ΠΎΠ³ΠΈΡ… странах. Одним ΠΈΠ· финансовых инструмСнтов ΡΠ²Π»ΡΡŽΡ‚ΡΡ ΠΎΠ±Π»ΠΈΠ³Π°Ρ†ΠΈΠΈ ΡΠΎΡ†ΠΈΠ°Π»ΡŒΠ½ΠΎΠ³ΠΎ воздСйствия. Апробация ΠΏΡ€ΠΎΠ³Ρ€Π°ΠΌΠΌ ΠΏΡ€ΠΎΡ„ΠΈΠ»Π°ΠΊΡ‚ΠΈΠΊΠΈ оТирСния Ρƒ Π΄Π΅Ρ‚Π΅ΠΉ Π² БвСрдловской области ΠΌΠΎΠΆΠ΅Ρ‚ Π±Ρ‹Ρ‚ΡŒ Ρ€Π΅Π°Π»ΠΈΠ·ΠΎΠ²Π°Π½Π° Π² Ρ€Π°ΠΌΠΊΠ°Ρ… ΠΏΡ€ΠΎΠ΅ΠΊΡ‚Π° ΡΠΎΡ†ΠΈΠ°Π»ΡŒΠ½ΠΎΠ³ΠΎ воздСйствия

    Green Universities in the Context of Safety

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    Π’ ΡΡ‚Π°Ρ‚ΡŒΠ΅ рассмотрСна Ρ€ΠΎΠ»ΡŒ Β«Π—Π΅Π»Π΅Π½ΠΎΠ³ΠΎ унивСрситСта» Π² ΠΏΡ€ΠΎΠ΄Π²ΠΈΠΆΠ΅Π½ΠΈΠΈ устойчивого развития, ΠΎΡ…Ρ€Π°Π½Ρ‹ ΠΎΠΊΡ€ΡƒΠΆΠ°ΡŽΡ‰Π΅ΠΉ срСды ΠΈ Π·Π΅Π»Π΅Π½ΠΎΠΉ экономики Π½Π° локальном ΠΈ Ρ€Π΅Π³ΠΈΠΎΠ½Π°Π»ΡŒΠ½ΠΎΠΌ ΡƒΡ€ΠΎΠ²Π½Π΅. Π Π°Π·Π²ΠΈΡ‚ΠΈΠ΅ соврСмСнной ΠΎΠ±Ρ€Π°Π·ΠΎΠ²Π°Ρ‚Π΅Π»ΡŒΠ½ΠΎΠΉ срСды, Ρ„ΠΎΡ€ΠΌΠΈΡ€ΡƒΡŽΡ‰Π΅ΠΉ цСнности экологичСской ΠΊΡƒΠ»ΡŒΡ‚ΡƒΡ€Ρ‹ ΠΈ Π·Π΄ΠΎΡ€ΠΎΠ²ΠΎΠ³ΠΎ ΠΎΠ±Ρ€Π°Π·Π° ΠΆΠΈΠ·Π½ΠΈ позволяСт ΠΏΠΎΠ²Ρ‹ΡΠΈΡ‚ΡŒ ΡƒΡ€ΠΎΠ²Π΅Π½ΡŒ бСзопасности ΠΆΠΈΠ·Π½Π΅Π΄Π΅ΡΡ‚Π΅Π»ΡŒΠ½ΠΎΡΡ‚ΠΈ Π² унивСрситСтС.The article deals with the role of "Green University" in promoting sustainable development, environmental protection and green economy Wednesday at local and regional level. Development of modern education Wednesday, forming the value of ecological culture and healthy lifestyle allows you to increase the level of safety of human life at the University

    Cultural Heritage: Ideas of Russian Cosmists

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    The article considers the evolutionary ideas of Russian cosmologists who make up the cultural and scientific heritage of Russia: the relationship of man and the Cosmos; man is part of the energy structure of the Cosmos; the influence of phenomena occurring in Space on all processes on Earth; the energy of thought; the continuity of life as a cosmic phenomenon.Π’ ΡΡ‚Π°Ρ‚ΡŒΠ΅ рассмотрСны ΡΠ²ΠΎΠ»ΡŽΡ†ΠΈΠΎΠ½Π½Ρ‹Π΅ ΠΈΠ΄Π΅ΠΈ русских ΡƒΡ‡Π΅Π½Ρ‹Ρ…-космистов, ΡΠΎΡΡ‚Π°Π²Π»ΡΡŽΡ‰ΠΈΠ΅ ΠΊΡƒΠ»ΡŒΡ‚ΡƒΡ€Π½ΠΎΠ΅ ΠΈ Π½Π°ΡƒΡ‡Π½ΠΎΠ΅ наслСдиС России: взаимосвязь Ρ‡Π΅Π»ΠΎΠ²Π΅ΠΊΠ° ΠΈ Космоса; Ρ‡Π΅Π»ΠΎΠ²Π΅ΠΊ – Ρ‡Π°ΡΡ‚ΡŒ энСргСтичСской структуры Космоса; влияниС происходящих Π² КосмосС явлСний Π½Π° всС процСссы Π½Π° Π—Π΅ΠΌΠ»Π΅; энСргия мысли; Π½Π΅ΠΏΡ€Π΅Ρ€Ρ‹Π²Π½ΠΎΡΡ‚ΡŒ ΠΆΠΈΠ·Π½ΠΈ ΠΊΠ°ΠΊ космичСскоС явлСниС

    Cultural Imperatives of the Modern Economy

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    Π’ ΡΡ‚Π°Ρ‚ΡŒΠ΅ рассмотрСна тСсная взаимосвязь ΠΊΡƒΠ»ΡŒΡ‚ΡƒΡ€Ρ‹ ΠΈ экономики, которая ΠΏΡ€Π΅Ρ‚Π΅Ρ€ΠΏΠ΅Π²Π°Π»Π° сущСствСнныС измСнСния Π½Π° протяТСнии Π΄ΠΎΠ»Π³ΠΎΠ³ΠΎ Π²Ρ€Π΅ΠΌΠ΅Π½ΠΈ. Показано, Ρ‡Ρ‚ΠΎ Π² соврСмСнном ΠΌΠΈΡ€Π΅ ΠΎΡ‚Π½ΠΎΡˆΠ΅Π½ΠΈΡ ΠΌΠ΅ΠΆΠ΄Ρƒ ΠΊΡƒΠ»ΡŒΡ‚ΡƒΡ€ΠΎΠΉ ΠΈ экономикой вновь ΡΠ±Π»ΠΈΠΆΠ°ΡŽΡ‚ΡΡ. МногиС ΡƒΡ‡Π΅Π½Ρ‹Π΅ ΠΈ экономисты ΡΡ‡ΠΈΡ‚Π°ΡŽΡ‚, Ρ‡Ρ‚ΠΎ ΠΎΡ‚ успСха этого сблиТСния Π²ΠΎ ΠΌΠ½ΠΎΠ³ΠΎΠΌ зависит Π²Ρ‹ΠΆΠΈΠ²Π°Π½ΠΈΠ΅ чСловСчСства Π½Π° ΠΏΠ»Π°Π½Π΅Ρ‚Π΅.The article examines the close relationship between culture and the economy, which has undergone significant changes over time. It is shown that in the modern world, the relationship between culture and the economy is again approaching. Many scientists and economists believe that the success of this convergence largely depends on the survival of humanity on the planet

    Questions of delivery of health care to patients of young and middle age with violation of lipid exchange

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    This study is devoted to the analysis of the main stages of providing medical care to young patients with lipid spectrum disorders in the Russian FederationНастоящСС исслСдованиС посвящСно ΠΈΠ·ΡƒΡ‡Π΅Π½ΠΈΡŽ Ρ€Π°ΡΠΏΡ€ΠΎΡΡ‚Ρ€Π°Π½Π΅Π½Π½ΠΎΡΡ‚ΡŒ дислипидСмии срСди Π»ΠΈΡ† ΠΌΠΎΠ»ΠΎΠ΄ΠΎΠ³ΠΎ ΠΈ срСднСго возраста, ΠΏΠΎΠ΄Ρ…ΠΎΠ΄ΠΎΠ² ΠΊ Ρ„ΠΎΡ€ΠΌΠΈΡ€ΠΎΠ²Π°Π½ΠΈΡŽ Π³Ρ€ΡƒΠΏΠΏ риска ΠΈ ΡΠΎΠ²Π΅Ρ€ΡˆΠ΅Π½ΡΡ‚Π²ΠΎΠ²Π°Π½ΠΈΡ оказания мСдицинской ΠΏΠΎΠΌΠΎΡ‰

    Cytological features of buccal epithelium in children with obesity

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    The article discusses the features of the buccal cytology in children with obesity.The buccal cytology was evaluated according to the following criteria: normal cells (superficial, intermediate), cells with karyological abnormalities (micronuclei, protrusions, nucleus vacuolization, binuclear cells, karyopyknosis,chromatin condensation, cells with signs of karyorexis, karyolysis, apoptotic bodies). An analysis of the data revealed that the number of intermediate cells in healthy and obese children is different. In the group of obese children, there is a tendency to increase the amount of karyological abnormalities.Π’ ΡΡ‚Π°Ρ‚ΡŒΠ΅ Ρ€Π°ΡΡΠΌΠ°Ρ‚Ρ€ΠΈΠ²Π°ΡŽΡ‚ΡΡ особСнности Π±ΡƒΠΊΠΊΠ°Π»ΡŒΠ½ΠΎΠΉ Ρ†ΠΈΡ‚ΠΎΠ³Ρ€Π°ΠΌΠΌΡ‹ Π΄Π΅Ρ‚Π΅ΠΉ с ΠΎΠΆΠΈΡ€Π΅Π½ΠΈΠ΅ΠΌ. ΠžΡ†Π΅Π½ΠΊΠ° цитологичСских особСнностСй ΠΏΡ€ΠΎΠ²ΠΎΠ΄ΠΈΠ»Π°ΡΡŒ ΠΏΠΎ ΡΠ»Π΅Π΄ΡƒΡŽΡ‰ΠΈΠΌ ΠΏΡ€ΠΈΠ·Π½Π°ΠΊΠ°ΠΌ: Π½ΠΎΡ€ΠΌΠ°Π»ΡŒΠ½Ρ‹Π΅ ΠΊΠ»Π΅Ρ‚ΠΊΠΈ (повСрхностныС,ΠΏΡ€ΠΎΠΌΠ΅ΠΆΡƒΡ‚ΠΎΡ‡Π½Ρ‹Π΅), ΠΊΠ»Π΅Ρ‚ΠΊΠΈ с кариологичСскими аномалиями (микроядра, ΠΏΡ€ΠΎΡ‚Ρ€ΡƒΠ·ΠΈΠΈ, вакуолизация ядра, двуядСрныС ΠΊΠ»Π΅Ρ‚ΠΊΠΈ, ΠΊΠ°Ρ€ΠΈΠΎΠΏΠΈΠΊΠ½ΠΎΠ·, кондСнсацияхроматина, ΠΊΠ»Π΅Ρ‚ΠΊΠΈ с ΠΏΡ€ΠΈΠ·Π½Π°ΠΊΠ°ΠΌΠΈ кариорСксиса, кариолизиса, Π°ΠΏΠΎΠΏΡ‚ΠΎΠ·Π½Ρ‹Π΅Ρ‚Π΅Π»ΡŒΡ†Π°). ΠŸΡ€ΠΈ Π°Π½Π°Π»ΠΈΠ·Π΅ Π΄Π°Π½Π½Ρ‹Ρ… Π±Ρ‹Π»ΠΎ выявлСно, Ρ‡Ρ‚ΠΎ количСство ΠΏΡ€ΠΎΠΌΠ΅ΠΆΡƒΡ‚ΠΎΡ‡Π½Ρ‹Ρ…ΠΊΠ»Π΅Ρ‚ΠΎΠΊ Ρƒ Π·Π΄ΠΎΡ€ΠΎΠ²Ρ‹Ρ… Π΄Π΅Ρ‚Π΅ΠΉ ΠΈ Π΄Π΅Ρ‚Π΅ΠΉ с ΠΎΠΆΠΈΡ€Π΅Π½ΠΈΠ΅ΠΌ ΠΎΡ‚Π»ΠΈΡ‡Π°ΡŽΡ‚ΡΡ. Π’ Π³Ρ€ΡƒΠΏΠΏΠ΅ Π΄Π΅Ρ‚Π΅ΠΉ с ΠΎΠΆΠΈΡ€Π΅Π½ΠΈΠ΅ΠΌ Π΅ΡΡ‚ΡŒ тСндСнция ΠΊ ΡƒΠ²Π΅Π»ΠΈΡ‡Π΅Π½ΠΈΡŽ суммы кариологичСских Π°Π½ΠΎΠΌΠ°Π»ΠΈΠΉ
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