Introduction to nonlinearities, business cycles, and forecasting

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Introduction to nonlinearities, business cycles, and forecasting.

Forecasting; Business cycles;

Study protocol on social return on investment (SROI) project of the surgical waiting list management system

In Andalusia, the right to maximum waiting times for healthcare clashes with the available supply, leading to an increase in demand in the form of waiting lists. To address this situation, the activity of private centers has been created for certain diagnostic tests. The Social Return on Investment (SROI) model evaluates an intervention from an economic and stakeholder perspective. However, there are no studies on the suitability of waiting lists using SROI, which is why it is intended to be studied as a decision-making tool for the clinical and healthcare management of waiting lists. This research protocol is designed to determine the quality of life gained, with the EuroQol-5D-5L questionnaire, and its social assessment, with the specific survey of the SROI method, and, thus, analyze the social return on investment and determine the suitability of the intervention (diagnostic endoscopy activity arranged in a contracted center). After the study, we will know the economic (cost in public health centers and the incremental cost of extraordinary health resources), social (quality of life with health), and environmental scenarios of the concerted activity intervention in order to adjust waiting list timesPartial funding for open access charge: Universidad de Málag

VNUML vs GNS3 en el desarrollo de laboratorios de redes virtuales

El aprendizaje práctico de redes de computadores es reconocido como un proceso crítico que permite a los estudiantes consolidar los conceptos introducidos en las lecciones teóricas. En este sentido, las tecnologías de virtualización están adquiriendo gran relevancia debido a que permiten desarrollar laboratorios de redes de computadores con un reducido coste de despliegue y gestión. Este artículo presenta un análisis comparativo entre GNS3 y VNUML, que son herramientas de virtualización open-source que han sido empleadas para el desarrollo de laboratorios de red virtuales para llevar a cabo el proceso de enseñanza-aprendizaje en las asignaturas Arquitectura de Redes y Arquitectura de Redes Avanzadas del Grado en Ingeniería Informática impartido en la Universidad de Murcia. El estudio presenta las principales ventajas y/o deficiencias de cada herramienta tanto para profesores como alumnos y se identifican los escenarios en los que parece más adecuada su utilización.SUMMARY -- The practical learning of computer networks is known to be a critical process in order to allow students to consolidate the concepts introduced in theoretical lessons. In this sense, virtualization technologies are becoming popular since they allow to set up a computer network laboratory with a reduced deployment and management cost. This paper presents a comparative analysis performed between GNS3 and VNUML, which are open-source tools for virtualization that have been used for developing virtual network laboratories that support the teaching-learning process in the Networks Architecture and Advanced Networks Architecture subjects of the Computer Engineering degree at the University of Murcia. The study presents the main advantages and/or deficiencies of each tool not only for professors but also for students and identifies the scenarios where the use of each tool seems to be more appropriate.Peer Reviewe

Benefit-risk assessment of sonidegib and vismodegib in the treatment of locally advanced basal cell carcinoma

Sonidegib and vismodegib are Hedgehog pathway inhibitors (HhIs) that play a relevant role in the management of locally advanced basal cell carcinoma (laBCC). This study compared the efficacy and safety of both HhIs based on their available data using effect size measures such as number needed to treat (NNT), number needed to harm (NNH), and likelihood to be helped or harmed (LHH)

Relativistic Runge-Lenz vector: from N=4{\cal N}=4 SYM to SO(4) scalar field theory

Starting from ${\cal N}=4$ SYM and using an appropriate Higgs mechanism we reconsider the construction of a scalar field theory non-minimally coupled to a Coulomb potential with a relativistic SO(4) symmetry and check for scalar field consistency conditions. This scalar field theory can also be obtained from a relativistic particle Lagrangian with a proper implementation of the non-minimal coupling. We provide the generalization of the non-relativistic construction of the Runge-Lenz vector to the relativistic case and show explicitly that this new vector generates the SO(4) algebra. Using the power of the SO(4) symmetry, we calculate the relativistic hydrogen atom spectrum. We provide a generalization of the Kustaanheimo-Stiefel transformation to the relativistic case and relate our results with the corresponding relativistic oscillator. Finally, in the light of these results, we reconsider the calculation of the hydrogen atom spectrum from the cusp anomalous dimension given in [2].Comment: 17 pages. Enhaced version matching the published JHEP version. Typos corrected. The argument of concistence at the end of section 2 was correcte

Information in feedback ratchets

Feedback control uses the state information of the system to actuate on it. The information used implies an effective entropy reduction of the controlled system, potentially increasing its performance. How to compute this entropy reduction has been formally shown for a general system, and has been explicitly computed for spatially discrete systems. Here, we address a relevant example of how to compute the entropy reduction by information in a spatially continuous feedback-controlled system. Specifically, we consider a feedback flashing ratchet, which constitutes a paradigmatic example for the role of information and feedback in the dynamics and thermodynamics of transport induced by the rectification of Brownian motion. A Brownian particle moves in a periodic potential that is switched on and off by a controller, with the latter performing the switching depending on the system state. We show how the entropy reduction can be computed from the entropy of a sequence of control actions, and also discuss the required sampling effort for its accurate computation. Moreover, the output power developed by the particle against an external force is investigated, which -- for some values of the system parameters -- is shown to become larger than the input power due to the switching of the potential: the apparent efficiency of the ratchet thus becomes higher than one, if the entropy reduction contribution is not considered. This result highlights the relevance of including the entropy reduction by information in the thermodynamic balance of feedback controlled devices, specifically when writing the second principle: the inclusion of the entropy reduction by information leads to a well-behaved efficiency over all the range of parameters investigated.Comment: 17 pages, 13 figure

Abordaje de pacientes con diabetes y obesidad en atención primaria

Aims: The aim of this study is to analyse the effect of pharmacological and non-pharmacological treatment on weight control in patients with diabetes and obesity. Design: Epidemiological, descriptive, cross-sectional study. Site: Primary care. In 11 health centres in Málaga and Cádiz during April and October 2022. Participants: 281 patients over 18 years old with type 2 diabetes and obesity are included. Main measurements: Socio-demographics, clinical, treatment and lifestyle habits variables were obtained from medical records and personal interview. Descriptive statistics were obtained for continuous variables. Statistical tests were performed based on the nature of the variables. Results: Variables like marital status, level of education and occupation, and smoking habit, shows differences regarding the sex ( p < 0.05). 82.3% of those who received education lost weight, compared to 67.5% of lost weight who received no health education ( p = 0.004). GLP1 and SGLT2 were more commonly prescribed for women ( p = 0.048), and SGLT2 more commonly prescribed for men ( p = 0.047). Patients taking GLP1, SGLT2 or both, regardless of sex, weight loss during the study period was − 3.1 kg (SE: 0.60), while the loss of those who took other medications was − 1.33 kg (SE: 0.62). The mean difference was 1.75 kg ( p = 0.046). Conclusions: In terms of weight loss, obese diabetics who took GLP1, SGLT2 or both were 2.5 times more likely to lose weight than those who did not. Healthy lifestyle choices are key to weight loss in obese diabetic patientsPartial funding for open Access charge: Universidad de Málaga / CBU

Observational Δν\Delta\nu-ρˉ\bar\rho relation for δ\delta Sct stars using eclipsing binaries and space photometry

Delta Scuti ($\delta$ Sct) stars are intermediate-mass pulsators, whose intrinsic oscillations have been studied for decades. However, modelling their pulsations remains a real theoretical challenge, thereby even hampering the precise determination of global stellar parameters. In this work, we used space photometry observations of eclipsing binaries with a $\delta$ Sct component to obtain reliable physical parameters and oscillation frequencies. Using that information, we derived an observational scaling relation between the stellar mean density and a frequency pattern in the oscillation spectrum. This pattern is analogous to the solar-like large separation but in the low order regime. We also show that this relation is independent of the rotation rate. These findings open the possibility of accurately characterizing this type of pulsator and validate the frequency pattern as a new observable for $\delta$ Sct stars.Comment: 11 pages, including 2 pages of appendix, 2 figures, 2 tables, accepted for publication in ApJ