Políticas públicas sectoriales: análisis comparativo en perspectiva histórica para el sector informático en Argentina

Se analizan las políticas públicas aplicadas al sector industrial informático en dos periodos diferentes por medio de sus características, aciertos y déficits, para finalmente poder comparar estos procesos diacrónicos y reflexionar al respecto.Sociedad Argentina de Informática e Investigación Operativ

Non Ionizing Radiation: development of fixed stations that allow their monitoring through the Internet Network Monitors

The present work aims to describe the development of a fixed station to monitor NIR. Using Internet access, this monitoring detection service enables public display of the location of the station, the radiation level, and its evolution throughout the day. The design takes into account availability, accessibility, and feasibility of the technological and human resources in our country.Presentado en el V Workshop Arquitectura, Redes y Sistemas Operativos (WARSO)Red de Universidades con Carreras en Informática (RedUNCI

Políticas públicas sectoriales: análisis comparativo en perspectiva histórica para el sector informático en Argentina

Se analizan las políticas públicas aplicadas al sector industrial informático en dos periodos diferentes por medio de sus características, aciertos y déficits, para finalmente poder comparar estos procesos diacrónicos y reflexionar al respecto.Sociedad Argentina de Informática e Investigación Operativ

The single salt approximation for the major components of seawater: association and acid–base properties

In this note we propose the use of the single salt approximation for the composition of seawater. This approximation has been applied to a synthetic seawater. Association and acid-base properties h..

New Target Genes for the Peroxisome Proliferator-Activated Receptor-γ (PPARγ) Antitumour Activity: Perspectives from the Insulin Receptor

The insulin receptor (IR) plays a crucial role in mediating the metabolic and proliferative functions triggered by the peptide hormone insulin. There is considerable evidence that abnormalities in both IR expression and function may account for malignant transformation and tumour progression in some human neoplasias, including breast cancer. PPARγ is a ligand-activated, nuclear hormone receptor implicated in many pleiotropic biological functions related to cell survival and proliferation. In the last decade, PPARγ agonists—besides their known action and clinical use as insulin sensitizers—have proved to display a wide range of antineoplastic effects in cells and tissues expressing PPARγ, leading to intensive preclinical research in oncology. PPARγ and activators affect tumours by different mechanisms, involving cell proliferation and differentiation, apoptosis, antiinflammatory, and antiangiogenic effects. We recently provided evidence that PPARγ and agonists inhibit IR by non canonical, DNA-independent mechanisms affecting IR gene transcription. We conclude that IR may be considered a new PPARγ “target” gene, supporting a potential use of PPARγ agonists as antiproliferative agents in selected neoplastic tissues that overexpress the IR

Communication access to small and remote communities: the Corral de Lorca project

Throughout Argentina, like in many developing countries, several ru-ral areas with low population density are present. This distribution becomes an obstacle when seeking solutions to provide broadband services with an efficient internet connection. Alternative solutions are explored which differ from those regularly implemented in developed countries. The solutions examined are re-lated to the use of long range wireless technologies, such as microwaves, 802.11, WiMax, CDMA450 and others with similar features. The reasons be-hind the implementation of these networks are associated to the speed and lack of difficulty of their set up, as well as the capability to use frequencies without requiring previous authorization. In addition, they avoid reliance on local com-munication operators. The present work discusses the implementation of 802.11 technology in these areas. Its behavior is analyzed for large coverage areas which differ from the well known solutions employed in large urban settings, where its application for short distances is consistent to its design. In particular, the case of the Corral de Lorca village, in the Argentine province of Mendoza, is presented.IV Workshop Arquitectura, Redes y Sistemas Operativos (WARSO)Red de Universidades con Carreras en Informática (RedUNCI

Design of a Trans-Horizon radio link for ultra high and super high frequencies

Cost considerations and availability of frequencies condition the feasibility of links at distances in which there is no line of sight between antennas. These trans-horizon links require precise design procedures to determine whether the intensity of the signal and its noise ratio allow reception with reasonable quality. The present work describes a procedure for radio electric link calculation to transmit voice and data signals through bandwidth at ultra high and super high frequencies.Presentado en el V Workshop Arquitectura, Redes y Sistemas Operativos (WARSO)Red de Universidades con Carreras en Informática (RedUNCI

Non Ionizing Radiation: development of fixed stations that allow their monitoring through the Internet Network Monitors

The present work aims to describe the development of a fixed station to monitor NIR. Using Internet access, this monitoring detection service enables public display of the location of the station, the radiation level, and its evolution throughout the day. The design takes into account availability, accessibility, and feasibility of the technological and human resources in our country.Presentado en el V Workshop Arquitectura, Redes y Sistemas Operativos (WARSO)Red de Universidades con Carreras en Informática (RedUNCI

Clinical Effectiveness and Safety of Once-Weekly GLP-1 Receptor Agonist Dulaglutide as Add-On to Metformin or Metformin Plus Insulin Secretagogues in Obesity and Type 2 Diabetes

Aims and methods: The aim of this monocentric retrospective observational study was to evaluate the 18-month safety and effectiveness of GLP-1 receptor agonist (GLP-1 RA) dulaglutide (DU) 1.5 mg/once weekly as an add-on to metformin (MET) or MET plus conventional insulin secretagogues in a study cohort with excess body weight and type 2 diabetes (T2D). Comparative efficacy versus liraglutide (LIRA) 1.2–1.8 mg/once daily in a study sample naïve to GLP-1 RAs, frequency matching for age, gender, T2D duration, degree of glycemic impairment, cardiovascular comorbidities, and medications, was addressed as a secondary aim. Clinical and biochemical data for efficacy outcomes and information on drug discontinuation due to adverse events (AEs) were collected from digital records. Results: Initial analysis included 126 overweight and obese T2D patients (48.4% females). Out of these, 13 discontinued DU due to moderate–severe gastrointestinal AEs after a mean follow-up of 6 (4 standard deviations (SD)) months, while 65 completed 18 months of continuous therapy. At 6 months, there was a significant mean HbA1c reduction of −0.85% (1.17 SD) with respect to baseline values (p < 0.001), which remained stable during 18 months follow-up. These results were accompanied by a moderate weight loss sustained over time, with a mean reduction of −2.0% (4.3 SD) at 6 months and −1.3% (4.8 SD) at 18 months (p = 0.091). At univariate analysis, a negative correlation between baseline body mass index (BMI) and risk of drug discontinuation due to gastrointestinal AEs was observed. The protective effect of obesity against drug discontinuation was confirmed by logistic regression analysis. Neither gender, nor age, nor T2D duration, nor concomitant conventional insulin secretagogue use, nor switching to DU from other GLP-1 RAs influenced its long-term effectiveness. However, higher baseline HbA1c values emerged as predictors of clinically relevant efficacy outcomes, either in terms of HbA1c reduction ≥ 0.5% or body weight loss ≥ 5%. The efficacy outcomes were corroborated by head-to-head comparison with LIRA, a GLP-1 RA with durable beneficial effects on glycemic control and body weight in real-world experiences. With the advantage of once-weekly administration, at 18-month follow-up, a significantly larger fraction of patients on DU therapy reached glycemic targets (HbA1c ≤ 7.0%) when compared to those on LIRA: from 14.8% at baseline (both groups) to 64.8% with DU and 42.6% with LIRA (p = 0.033). Conclusions: Although limited by a retrospective design and lack of constant up-titration for LIRA to the highest dose, these findings indicate that the beneficial responses to DU on a background of MET or MET plus insulin secretagogues are durable, especially in the presence of obesity and greater HbA1c impairment