Mixing-induced Spontaneous Supersymmetry Breaking

It is conjectured that flavor mixing furnishes a universal mechanism for the spontaneous breaking of supersymmetry. The conjecture is proved explicitly for the mixing of two Wess--Zumino $\mathcal{N}=1$ supermultiplets and arguments for its general validity are given. The mechanism relies on the fact that, despite mixing treats fermions and bosons symmetrically, both the fermionic and the bosonic zero point energies are shifted by a positive amount and this kind of shift does not respect supersymmetry.Comment: 5 pages, 1 figure, Eq(12) of V1 corrected to Eq(22), explicit off-shell formulation included, one reference adde

Fine-root morphological and growth traits in a Turkey-oak stand in relation to seasonal changes in soil moisture in the Southern Apennines, Italy

We investigated the effects of seasonal changes in soil moisture on the morphological and growth traits of fine roots (<2 mm in diameter) in a mature Turkeyoak stand (Quercus cerris L.) in the Southern Apennines of Italy. Root samples (diameter: <0.5, 0.5\u20131.0, 1.0\u20131.5, and 1.5\u20132.0 mm) were collected with the Auger method. Mean annual fine-root mass and length on site was 443 g m!2 (oak fine roots 321 g m!2; other species 122 g m!2) and 3.18 km m!2 (oak fine roots 1.14 km m!2; other species 2.04 km m!2), respectively. Mean specific root length was 8.3 m g!1. All fine-root traits displayed a complex pattern that was significantly related to season. In the four diameter classes, both fineroot biomass and length peaked in summer when soil water content was the lowest and air temperature the highest of the season. Moreover, both fine-root biomass and length were inversely related with soil moisture (p < 0.001). The finest roots (<0.5 mm in diameter) constituted an important fraction of total fine-root length (79 %), but only 21 % of biomass. Only in this root class, consequent to change in mean diameter, specific root length peaked when soil water content was lowest showing an inverse relationship (p < 0.001). Furthermore, fine-root production and turnover decreased with increasing root diameter. These results suggest that changes in root length per unit mass, and pulses in root growth to exploit transient periods of low soil water content may enable trees to increase nutrient and water uptake under seasonal drought conditions

Kidney Disease in HIV Infection

Antiretroviral therapy (ART) has significantly improved life expectancy of infected subjects, generating a new epidemiological setting of people aging withHuman Immunodeficiency Virus (HIV). People living with HIV (PLWH), having longer life expectancy, now face several age-related conditions as well as side effects of long-term exposure of ART. Chronic kidney disease (CKD) is a common comorbidity in this population. CKD is a relentlessly progressive disease that may evolve toward end-stage renal disease (ESRD) and significantly affect quality of life and risk of death. Herein, we review current understanding of renal involvement in PLWH, mechanisms and risk factors for CKD as well as strategies for early recognition of renal dysfunction and best care of CKD

Memoria escrita de las lenguas en Misiones: Un análisis discursivo. 16H297

Reuniones mensuales de discusión de lecturas y procesos conceptuales. Agenda de las reuniones: a) Puesta en balance de las tramas conjeturales en torno del objeto Memoria–Lenguas–Escritura; b) Intensificación del trabajo con la instancia enunciativa (Autoría), las modalidades genéricas y estrategias del gesto memorioso; c) Ponderación de la configuración del archivo en base al acervo documental encontrado hasta el momento; d) Vinculación del proyecto con el proceso de cursado de la Maestría en Semiótica Discursiva del Lic. Di Iorio

A novel integrated industrial approach with cobots in the age of industry 4.0 through conversational interaction and computer vision

From robots that replace workers to robots that serve as helpful colleagues, the field of robotic automation is experiencing a new trend that represents a huge challenge for component manufacturers. The contribution starts from an innovative vision that sees an ever closer collaboration between Cobot, able to do a specific physical job with precision, the AI world, able to analyze information and support the decision-making process, and the man able to have a strategic vision of the future

Predictive Value ofMeasures of Vascular Calcification Burden and Progression for Risk of Death in Incident to Dialysis Patients

Abstract: Background: Vascular calcification (VC) is a marker of cardiovascular (CV) disease and various methods allow for presence and extension assessment in different arterial districts. Nevertheless, it is currently unclear which one of these methods for VC evaluation best predict outcome and if this piece of information adds to the predictive value of traditional CV risk factors in patients receiving hemodialysis (HD). Methods: data of 184 of the 466 patients followed in the Independent study (NCT00710788) were post hoc examined to assess the association three concurrent measures of vascular calcification and all-cause survival. Specifically, coronary artery calcification (CAC) was determined by the Agatston and the volume score while abdominal aorta calcification was determined by plain X-ray of the lumbar spine (Kauppila score (KS)). Survival and regression models as well as metrics of risk recalculation were used to test the association of VC and outcome beyond the Framingham risk score. Results: Middle-age (62.6(15.8) years) men (51%) and women (49%) starting HD were analyzed. Over 36 (median 36; interquartile range: 8–36) months of follow-up 69 patients expired. Each measure of VC (CAC or KS) predicted all-cause mortality independently factors commonly associated with all-cause survival (p &lt; 0.001). Far more importantly, each measurement of VC significantly improved risk prediction and patient reclassification (p &lt; 0.001) beyond traditional cardiovascular risk factors. Conclusions: Overall, presence and extension of VC, irrespective of the arterial site, predict risk of all-cause of death in patients starting hemodialysis. Of note, both CAC and KS increase risk stratification beyond traditional CV risk factors. However, future efforts are needed to assess whether a risk-based approach encompassing VC screening to guide HD patient management improves survival

Digenic mutational inheritance of the integrin alpha 7 and the myosin heavy chain 7B genes causes congenital myopathy with left ventricular non-compact cardiomyopathy

BACKGROUND: We report an Italian family in which the proband showed a severe phenotype characterized by the association of congenital fiber type disproportion (CFTD) with a left ventricular non-compaction cardiomyopathy (LVNC). This study was focused on the identification of the responsible gene/s. METHODS AND RESULTS: Using the whole-exome sequencing approach, we identified the proband homozygous missense mutations in two genes, the myosin heavy chain 7B (MYH7B) and the integrin alpha 7 (ITGA7). Both genes are expressed in heart and muscle tissues, and both mutations were predicted to be deleterious and were not found in the healthy population. The R890C mutation in the MYH7B gene segregated with the LVNC phenotype in the examined family. It was also found in one unrelated patient affected by LVNC, confirming a causative role in cardiomyopathy. The E882K mutation in the ITGA7 gene, a key component of the basal lamina of muscle fibers, was found only in the proband, suggesting a role in CFTD. CONCLUSIONS: This study identifies two novel disease genes. Mutation in MYH7B causes a classical LVNC phenotype, whereas mutation in ITGA7 causes CFTD. Both phenotypes represent alterations of skeletal and cardiac muscle maturation and are usually not severe. The severe phenotype of the proband is most likely due to a synergic effect of these two mutations. This study provides new insights into the genetics underlying Mendelian traits and demonstrates a role for digenic inheritance in complex phenotypes