Enhancing the navigability in a social network of smart objects: a Shapley-value based approach

The Internet of Things (IoT) holds the promise to interconnect any possible object capable of providing useful information about the physical world for the benefit of humans' quality of life. The increasing number of heterogeneous objects that the IoT has to manage introduces crucial scalability issues that still need appropriate solutions. In this respect, one promising proposal is the Social IoT (SIoT) paradigm, whose main principle is to enable objects to autonomously establish social links with each other (adhering to rules set by their owners). "Friend" objects exchange data in a distributed manner and this avoids centralized solutions to implement major functions, such as: node discovery, information search, and trustworthiness management. However, the number and types of established friendships affect network navigability. This issue is the focus of this paper, which proposes an efficient, distributed and dynamic solution for the objects to select the right friends for the benefit of the overall network connectivity. The proposed friendship selection mechanism relies on a game theoretic model and a Shapley-value based algorithm. Two different utility functions are defined and evaluated based on either a group degree centrality and an average local clustering parameter. The comparison in terms of global navigability is measured in terms of average path length for the interconnection of any couple of nodes in the network. Results show that the group degree centrality brings to an enhanced degree of navigability thanks to the ability to create a suitable core of hubs

Short communication: In vitro rumen gas production and starch degradation of starch-based feeds depend on mean particle size

Our objective was to model the effect of mean particle size (mPS) on in vitro rumen starch degradation (IVSD) and the kinetics of gas production for different starch-based feeds. For each feed, 2 batches of the same grains were separately processed through 2 different mills (cutter or rotor speed mills), with or without different screens to achieve a wide range of mPS (0.32 to 3.31 mm for corn meals; 0.19 to 2.81 mm for barley meals; 0.16 to 2.13 mm for wheat meals; 0.28 to 2.32 mm for oat meals; 0.21 to 2.36 mm for rye meals; 0.40 to 1.79 for sorghum meals; 0.26 to 4.71 mm for pea meals; and 0.25 to 4.53 mm for faba meals). The IVSD data and gas production kinetics, obtained by fitting to a single-pool exponential model, were analyzed using a completely randomized design, in which the main tested effect was mPS (n = 6 for all tested meals, except n = 7 for corn meals and n = 5 for sorghum meals). Rumen inocula were collected from 2 fistulated Holstein dairy cows that were fed a total mixed ration consisting of 16.2% crude protein, 28.5% starch, and 35.0% neutral detergent fiber on a dry matter basis. The IVSD, evaluated after 7 h of rumen incubation, decreased linearly with increasing mPS for corn, barley, wheat, rye, pea, and faba meals, and decreased quadratically with increasing mPS for the other meals. The y-axis intercept for 7-h IVSD was below 90% starch for corn, barley, and rye feeds and greater than 90% for the other tested feeds. The mPS adjustment factors for the rate of rumen starch degradation varied widely among the different tested feeds. We found a linear decrease in starch degradation with increasing mPS for barley, wheat, rye, and pea meals, whereas we noted a quadratic decrease in starch degradation for the other tested meals. Further, we observed a linear decrease in the rate of gas production with increasing mPS in each tested feed, except for pea meal, which had a quadratic relationship. For each 1 mm increase in mPS, the gas production was adjusted by -0.009 h-1 for corn, -0.011 h-1 for barley, -0.008 h-1 for wheat, and -0.006 h-1 for faba, whereas numerically greater adjustments were needed for oat (-0.022 h-1), rye (-0.017 h-1), and sorghum (-0.014 h-1). These mPS adjustment factors could be used to modify the starch-based feed energy values as a function of mean particle size, although in vivo validation is required

A metabolomic approach to animal vitreous humor topographical composition: A pilot study

The purpose of this study was to evaluate the feasibility of a 1H-NMR-based metabolomic approach to explore the metabolomic signature of different topographical areas of vitreous humor (VH) in an animal model. Five ocular globes were enucleated from five goats and immediately frozen at 280uC. Once frozen, three of them were sectioned, and four samples corresponding to four different VH areas were collected: the cortical, core, and basal, which was further divided into a superior and an inferior fraction. An additional two samples were collected that were representative of the whole vitreous body. 1H-NMR spectra were acquired for twenty-three goat vitreous samples with the aim of characterizing the metabolomic signature of this biofluid and identifying whether any site-specific patterns were present. Multivariate statistical analysis (MVA) of the spectral data were carried out, including Principal Component Analysis (PCA), Hierarchical Cluster Analysis (HCA), and Partial Least Squares Discriminant Analysis (PLS-DA). A unique metabolomic signature belonging to each area was observed. The cortical area was characterized by lactate, glutamine, choline, and its derivatives, N-acetyl groups, creatine, and glycerol; the core area was characterized by glucose, acetate, and scyllo-inositol; and the basal area was characterized by branched-chain amino acids (BCAA), betaine, alanine, ascorbate, lysine, and myo-inositol. We propose a speculative approach on the topographic role of these molecules that are mainly responsible for metabolic differences among the as-identified areas. 1H-NMR-based metabolomic analysis has shown to be an important tool for investigating the VH. In particular, this approach was able to assess in the samples here analyzed the presence of different functional areas on the basis of a different metabolite distribution.The purpose of this study was to evaluate the feasibility of a 1H-NMR-based metabolomic approach to explore the metabolomic signature of different topographical areas of vitreous humor (VH) in an animal model. Five ocular globes were enucleated from five goats and immediately frozen at -80°C. Once frozen, three of them were sectioned, and four samples corresponding to four different VH areas were collected: the cortical, core, and basal, which was further divided into a superior and an inferior fraction. An additional two samples were collected that were representative of the whole vitreous body. 1H-NMR spectra were acquired for twenty-three goat vitreous samples with the aim of characterizing the metabolomic signature of this biofluid and identifying whether any site-specific patterns were present. Multivariate statistical analysis (MVA) of the spectral data were carried out, including Principal Component Analysis (PCA), Hierarchical Cluster Analysis (HCA), and Partial Least Squares Discriminant Analysis (PLS-DA). A unique metabolomic signature belonging to each area was observed. The cortical area was characterized by lactate, glutamine, choline, and its derivatives, N-acetyl groups, creatine, and glycerol; the core area was characterized by glucose, acetate, and scyllo-inositol; and the basal area was characterized by branched-chain amino acids (BCAA), betaine, alanine, ascorbate, lysine, and myo-inositol. We propose a speculative approach on the topographic role of these molecules that are mainly responsible for metabolic differences among the as-identified areas. 1H-NMR-based metabolomic analysis has shown to be an important tool for investigating the VH. In particular, this approach was able to assess in the samples here analyzed the presence of different functional areas on the basis of a different metabolite distribution. © 2014 Locci et al

A subjective model for trustworthiness evaluation in the social Internet of Things

The integration of social networking concepts into the Internet of Things (IoT) has led to the so called Social Internet of Things (SIoT) paradigm, according to which the objects are capable of establishing social relationships in an autonomous way with respect to their owners. The benefits are those of improving scalability in information/service discovery when the SIoT is made of huge numbers of heterogeneous nodes, similarly to what happens with social networks among humans. In this paper we focus on the problem of understanding how the information provided by the other members of the SIoT has to be processed so as to build a reliable system on the basis of the behavior of the objects. We define a subjective model for the management of trustworthiness which builds upon the solutions proposed for P2P networks. Each node computes the trustworthiness of its friends on the basis of its own experience and on the opinion of the common friends with the potential service providers. We employ a feedback system and we combine the credibility and centrality of the nodes to evaluate the trust level. Preliminary simulations show the benefits of the proposed model towards the isolation of almost any malicious node in the network

MIFaaS: A Mobile-IoT-Federation-as-a-Service Model for dynamic cooperation of IoT Cloud Providers

In the Internet of Things (IoT) arena, a constant evolution is observed towards the deployment of integrated environments, wherein heterogeneous devices pool their capacities to match wide-ranging user requirements. Solutions for efficient and synergistic cooperation among objects are, therefore, required. This paper suggests a novel paradigm to support dynamic cooperation among private/public local clouds of IoT devices. Differently from . device-oriented approaches typical of Mobile Cloud Computing, the proposed paradigm envisages an . IoT Cloud Provider (ICP)-oriented cooperation, which allows all devices belonging to the same private/public owner to participate in the federation process. Expected result from dynamic federations among ICPs is a remarkable increase in the amount of service requests being satisfied. Different from the Fog Computing vision, the network edge provides only management support and supervision to the proposed Mobile-IoT-Federation-as-a-Service (MIFaaS), thus reducing the deployment cost of peripheral micro data centers. The paper proposes a coalition formation game to account for the interest of rational cooperative ICPs in their own payoff. A proof-of-concept performance evaluation confirms that obtained coalition structures not only guarantee the satisfaction of the players' requirements according to their utility function, but also these introduce significant benefits for the cooperating ICPs in terms of number of tasks being successfully assigned

Osservazioni sul regime alimentare di <i>Diplodus annularis</i> (Linnaeus, 1758) nello stagno di Calich (Sardegna nord occidentale) = Observations on the feeding behaviour of <i>Diplodus annularis</i> (Linnaeus, 1758) in the Calich Lagoon (North Western Sardinia)

Feeding behaviour of the annular sea bream Diplodus annularis was investigated in the Calich lagoon (NW Sardinia, Italy). The stomach contents of 130 adult specimens (TL=15.2±1.4 cm) collected in spring and summer 1998 were examined. Benthic fauna such as Mollusca, Amphipoda and Polychaeta were the main food items (23.4%, 18% and 5.7% respectively), but a large amount of detritus was also found (44%). Furthermore, significant differences in the diet of smaller and larger size classes were observed

Metabolomics in Otorhinolaryngology

Otorhinolaryngology (Ear, Nose and Throat-ENT) focuses on inflammatory, immunological, infectious, and neoplastic disorders of the head and neck and on their medical and surgical therapy. The fields of interest of this discipline are the ear, the nose and its paranasal sinuses, the oral cavity, the pharynx, the larynx, and the neck. Besides surgery, there are many other diagnostic aspects of ENT such as audiology and Vestibology, laryngology, phoniatrics, and rhinology. A new advanced technology, named metabolomics, is significantly impacting the field of ENT. All the “omics” sciences, such as genomics, transcriptomics, and proteomics, converge at the level of metabolomics, which is considered the integration of all “omics.” Its application will change the way several of ENT disorders are diagnosed and treated. This review highlights the power of metabolomics, including its pitfalls and promise, and several of its most relevant applications in ENT to provide a basic understanding of the metabolites associated with these districts. In particular, the attention has been focused on different heterogeneous diseases, from head and neck cancer to allergic rhinitis, hearing loss, obstructive sleep apnea, noise trauma, sinusitis, and Meniere’s disease. In conclusion, metabolomics study indicates a “fil rouge” that links these pathologies to improve three aspects of patient care: diagnostics, prognostics, and therapeutics, which in one word is defined as precision medicine

ProYoungStock: un progetto per promuovere il legame naturale tra vacca e vitello

This web article informs ruminant farmers and ruminant enthusiasts about the ProYoungStock project, with a brief insight into the main objectives and activities

Urografia-TC multidetettore: ruolo diagnostico nella valutazione del paziente con ematuria non traumatica

L’ematuria può originare da qualsiasi tratto dell’apparato urinario e può essere anche unico segno di patologia neoplastica (cancro del rene o della vescica). La letteratura raccomanda pertanto di sottoporre ad attenta valutazione clinico-strumentale tutti i casi di ematuria, macroscopica e microscopica. Lo scopo del presente contributo è quello di definire il ruolo diagnostico dell’urografia-TC multidetettore (uTC-MD) nella valutazione di questo sintomo e analizzarne l’impatto nel management del paziente attraverso lo studio di 181 pazienti consecutivi valutati per macro- e microematuria nel periodo compreso tra gennaio 2003 e marzo 2006

Metabolic profile of patients with severe endometriosis: a prospective experimental study

Endometriosis is a common disease affecting women in reproductive age. There are several hypotheses on the pathogenesis of this disease. Often, its lesions and symptoms overlap with those of many other medical and surgical conditions, causing a delay in diagnosis. Metabolomics represents a useful diagnostic tool for the study of metabolic changes during a different physiological or pathological status. We used 1H-NMR to explore metabolic alteration in a cohort of patients with endometriosis in order to contribute to a better understanding of the pathophysiology of the disease and to suggest new useful biomarkers. Thirty-seven patients were recruited for the metabolomic analysis: 22 patients affected by symptomatic endometriosis and 15 not affected by it. Their serum samples were collected and analyzed with 1H-NMR. Multivariate statistical analysis was conducted, followed by univariate and pathway analyses. Partial Least Square Discriminant Analysis (PLS-DA) was performed to determine the presence of any differences between the non-endometriosis and endometriosis samples (R2X = 0.596, R2Y = 0.713, Q2 = 0.635, and p &lt; 0.0001). β-hydroxybutyric acid and glutamine were significantly increased, whereas tryptophan was significantly decreased in the endometriosis patients. ROC curves were built to test the diagnostic power of the metabolites (β-hydroxybutyric acid: AUC = 0.85 CI = 0.71–0.99; glutamine: AUC = 0.83 CI = 0.68–0.98; tryptophan: AUC = 0.75 CI = 0.54–0.95; β-hydroxybutyric acid + glutamine + tryptophan AUC = 0.92 CI = 0.81–1). The metabolomic approach enabled the identification of several metabolic alterations occurring in women with endometriosis. These findings may provide new bases for a better understanding of the pathophysiological mechanisms of the disease and for the discovery of new biomarkers. Trial registration number NCT0233781