Cobalt(II) complexes with aromatic carboxylates and N-functionalized cyclam bearing 2-pyridylmethyl pendant arms

Novel binuclear Co(II) complexeswithN-functionalized cyclam, N,N’,N”,N’’’-tetrakis(2-pyridylmethyl)tetraazacyclotetradecane (tpmc) and one of the aromatic monoor dicarboxylato ligands (benzoate, phthalate or isophthalate ions) were prepared. They were analyzed and studied by elemental analyses (C, H, N), electrical conductivities, VIS and IR spectroscopy andmagnetic as well as cyclic voltammetric measurements. In [Co2(C6H5COO)2tpmc](ClO4)2.3H2O, the benzoate ligands are most probably coordinated as chelates in the trans-position to each Co(II) and the macrocycle adopts a chair conformation. In the complexes [Co2(Y)tpmc](ClO4)2·zH2O, (Y = phthalate or i-phthalate dianizon, z = 2; 4), it is proposed that the isomeric dicarboxylates are bonded combined as bridges and chelates. The composition and the assumed geometries of the complexes are compared with the, earlier reported, corresponding Cu(II) complexes. Cyclic voltammetry measurements showed that the compounds are electrochemically stable

Separation Mechanisms of Co(III) Complexes with EDTA-Type Ligands during Salting-Out TLC on Impregnated and Non-Impregnated Silica Gel

Free full text: [https://doi.org/10.1093/chromsci/bms072

Binuclear biologically active Co(II) complexes with octazamacrocycle and aliphatic dicarboxylates

Four new cationic Co(II) complexes with N,N',N '',N'''-tetrakis (2-pyridylmethyl)-1,4,8,11-tetraazacyclotetradecane (tpmc) and dianion of one the aliphatic dicarboxylic acids: butanedioic acid (succinic) acid = succH(2), pentanedioic (glutaric) acid = gluH(2), hexanedioic acid (adipic) acid = adipH(2) or decanedioic acid (sebacic) acid = sebH(2) of general formula [Co-2(L)(tpmc)](ClO4)(2)center dot xY, L2- = succ, x = 1, Y = H2O; L = glu, x = 1, Y = H2O; L = adip, x = 1.5, Y = H2O; L = seb, x = 1, Y = CH3CN were isolated. The composition and charge are proposed based on elemental analyses (C, H. N) and electrical conductivity measurements. UV-Vis and FTIR spectral data and magnetic moments were in accordance with high-spin Co(II) state. It is proposed that in all complexes Co(II) is hexa-coordinated out of cyclam ring and that both carboxylic groups from dicarboxylate bridge participate in coordination. Oxygens from one group are most likely bonded to the same Co(II) ion thus forming a four-membered ring. The in vitro antibacterial/antiproliferative activities of the complexes were in some cases enhanced compared with the simple Co(II) salt and free ligands, tested as controls

Magnetic, electrochemical and antimicrobial properties of some Cu(II) complexes with TPMC

Three complexes: [Cu-2(C6H5COO)tpmc](ClO4)(3)center dot CH3OH, (A), (tpmc = N,N',N'',N''' tetrakis(2-pyridilmethyl)-1,4,8,11-tetraazacyclotetradecane), [Cu-2(Hpht)tpmc](ClO4)(3)center dot 3H(2)O (H(2)pht = phtalic acid) (B) and [Cu-4(ipht)(tpmc)(2)](ClO4)(6)center dot NaClO(4)center dot 2CH(3)CN(H(2)ipht = isophtalic acid) (C) previously described were investigated by magnetic measurements, cyclic voltammetry (CV) and were tested towards some strains of microorganisms. It is found that all three complexes were electrochemically stable in the investigated ranges. The least stable was mu-ipht-complex (C) due to the reaction of central ion, which is seen from weak peaks in its cyclic voltammogram. Complexes were characterized by variable temperature magnetic measurements (4.2-300 K) and the observed data were successfully simulated by the equation based on the spin Hamiltonian operator, (H) over cap = -2J (S) over cap (1)(S) over cap (2), giving the ferromagnetic exchange parameters J = 0.92 cm(-1) for A, J = 0.55 cm(-1) for B and J = 0.65 cm(-1) for C. For the complex C model of molecular magnet with two magnetically isolated dimeric subunits was used. These results indicate the presence of weak ferromagnetic spin exchange interaction between the Cu-II magnetic centers within each molecule

Magnetic, electrochemical and antimicrobial properties of some Cu(II) complexes with TPMC

Three complexes: [Cu-2(C6H5COO)tpmc](ClO4)(3)center dot CH3OH, (A), (tpmc = N,N',N'',N''' tetrakis(2-pyridilmethyl)-1,4,8,11-tetraazacyclotetradecane), [Cu-2(Hpht)tpmc](ClO4)(3)center dot 3H(2)O (H(2)pht = phtalic acid) (B) and [Cu-4(ipht)(tpmc)(2)](ClO4)(6)center dot NaClO(4)center dot 2CH(3)CN(H(2)ipht = isophtalic acid) (C) previously described were investigated by magnetic measurements, cyclic voltammetry (CV) and were tested towards some strains of microorganisms. It is found that all three complexes were electrochemically stable in the investigated ranges. The least stable was mu-ipht-complex (C) due to the reaction of central ion, which is seen from weak peaks in its cyclic voltammogram. Complexes were characterized by variable temperature magnetic measurements (4.2-300 K) and the observed data were successfully simulated by the equation based on the spin Hamiltonian operator, (H) over cap = -2J (S) over cap (1)(S) over cap (2), giving the ferromagnetic exchange parameters J = 0.92 cm(-1) for A, J = 0.55 cm(-1) for B and J = 0.65 cm(-1) for C. For the complex C model of molecular magnet with two magnetically isolated dimeric subunits was used. These results indicate the presence of weak ferromagnetic spin exchange interaction between the Cu-II magnetic centers within each molecule

Stress neuropeptide levels in adults with chest pain due to coronary artery disease: potential implications for clinical assessment

: Substance P (SP) and neuropeptide Y (NPY) are neuropeptides involved in nociception. The study of biochemical markers of pain in communicating critically ill coronary patients may provide insight for pain assessment and management in critical care. Purpose of the study was to to explore potential associations between plasma neuropeptide levels and reported pain intensity in coronary critical care adults, in order to test the reliability of SP measurements for objective pain assessment in critical care