Comfort Driven Redesign: The Case of Library Chairs

AbstractUniversity students spend most of their time in a sitting position. Prolonged sitting on ill-fitted furniture and the resulting lousy posture is making students having different musculoskeletal disorders and is strictly related to students learning outcomes. This study aims to improve postural comfort of chairs placed inside the Science & Technology Library at the University of Salerno. A previous study about these library chairs showed that the lumbar area was the most suffering part while perceived (dis)comfort was dependent on time. Based on this, an ergonomic redesign and, consequently, manufacturing of the chair has been done. A perceived-comfort comparison between the library chair and the redesigned one has been performed. A statistical sample of 28 healthy students performed a 20-min experiment two times, alternatively on the library chair and the redesigned one. The 20-min experiment was divided into two 10-min tasks ("Reading & Writing" and "Laptop use") to simulate a study day. The participants' postures were acquired non-invasively using cameras and processed by Kinovea; questionnaires were used to rate the perceived subjective (dis)comfort. A procedure for improving an existing product through a comfort-driven redesign is proposed. Results showed the redesigned library chair lead on increasing postural comfort (particularly in the lumbar area) thanks to the new design and modifications

Erythropoietin exerts anti-apoptotic effects on rat microglial cells in vitro

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Diagnostic and infection control strategies for Clostridioides difficile infections in a setting of high antimicrobial resistance prevalence

Clostridioides difficile (CD) is a major nosocomial pathogen and the leading cause of antibiotic-associated diarrhoea. In light of the strong association between antimicrobial use and CD infections (CDI), it may be hypothesised that areas at higher prevalence of antimicrobial resistance, like the region of Campania in southern Italy, could also have a higher rate of CDI. In this multicentre, region-based, prospective study, we analysed such issues, exploiting CDI incidence data collected from local hospitals. In 2016, the Italian National Centre for Disease Control supported a project involving three Italian regions: Friuli Venezia Giulia, Lazio and Campania. In Campania, a network of 49 hospitals willing to participate in the project was created. The project consisted of two phases: a survey on practice patterns concerning CDI and an epidemiological surveillance study. We identified a stringent need to improve awareness about CDI among the regional health-care community, as a widespread lack of surveillance programmes for CDI control was observed (existing in only 40% of participating facilities). Moreover, almost half of the participating hospitals (n=16, 43%) had no standardised procedures or protocols to control and prevent CDI. In the second phase of the study, we collected data of CDI cases during a six-month surveillance programme. In all, 87 CDI cases were observed, for a total of 903,334 patient bed-days and 122,988 admissions. According to the above data, CDI incidence was 0.96 cases/10000 patient bed-days, much lower than expected based on prior studies conducted elsewhere. The results of our study suggest CDI remains a rather neglected clinical issue in Campania. Despite a high burden of antimicrobial resistance and antimicrobial use in our geographic setting, we observed a very low incidence of CDI. Such a low incidence could be explained by underdiagnosis, but could also be related to actual diet, the lower patient age or the specific genetic background. However, further studies are warranted to either confirm or rebut the above hypotheses