Franz Brentano et l’« inexistence intentionnelle »

La thèse de l’« inexistence intentionnelle » formulée par Brentano a été traditionnellement interprétée comme une théorie de la « relation intentionnelle », autrement dit de la relation entre l’acte mental et son « objet immanent » ou « intentionnel », c’est-à-dire interne à la conscience. Se fondant sur la lecture du fameux passage sur l’intentionnalité de la Psychologie du point de vue empirique (1874), le présent article démontre que l’interprétation ontologique de la théorie de l’intentionnalité du premier Brentano est insoutenable, toute dominante qu’elle est. Pour ce faire, nous partirons des sources de la pensée de Brentano, en particulier de la théorie de la perception et des relatifs d’Aristote, pour rejeter la conception de l’objet immanent ou intentionnel comme entité immanente à la conscience et mettre en évidence la continuité qui existe entre la première conception de Brentano de l’intentionnalité et la seconde, consécutive à ce qu’on définit comme le tournant réiste de sa pensée.Brentano’s thesis of “intentional inexistence” has been traditionally interpreted as a theory of “intentional relationships”, i.e., of the relation between a mental act and its “immanent” or “intentional object”, within consciousness. Starting from the famous passage on intentionality in Psychology from an Empirical Standpoint (1874), the present paper shows that the dominant ontological interpretation of Brentano’s former theory of intentionality is untenable. Proceeding from the sources of Brentano’s thought, in particular from Aristotle’s theory of perception and of relatives, the conception of the immanent or intentional object as an immanent entity to consciousness is rejected. Instead, the continuity between Brentano’s former conception of intentionality and the subsequent one, following the so-called reistic turning-point in his thought, is highlighted

New therapies, markers and therapeutic targets in HCV chronic infection, and HCV extrahepatic manifestations

More than 180 millions of subjects in the world are infected by Hepatitis C Virus (HCV), and about 20% of them with HCV chronic infection progress to cirrhosis. Furthermore, numerous HCV extrahepatic manifestations have been reported in up to 74% of patients, as mixed cryoglobulinemia, lymphomas, rheumatic disorders, autoimmune thyroiditis, hypothyroidism, papillary thyroid cancer, and type 2 diabetes. Advances in understanding the HCV life cycle, and the inflammatory processes (involving a complex network of cytokines and chemokines) associated with HCV chronic infection, have led to substantial advancements in therapy. The combination of ribavirin and PEGylated interferon-gamma was the standard of therapy for HCV chronically infected patients in the last decades. However, interferon has limited effectiveness and is associated with severe adverse effects. Recently, direct-acting antivirals (DAAs) that act as inhibitors of N5SA, or polymerase, or protease have been shown to result in shorter duration of therapy, better efficacy and tolerance, with respect to ribavirin and PEGylated interferon-gamma. Circulating CXCL10 levels, and the interleukin(IL)-28B gene polymorphisms, are associated with the success of the therapy both with DAAs or ribavirin and PEGylated interferon-alpha. New DAAs targeting the HCV at various molecular levels have been developed to eradicate HCV. Moving to interferon-free therapies should offer new treatments for resistant HCV genotypes, and for ineligible patients or patients failing to respond to prior therapies. Many efforts have been made to understand the factors that are involved with clearance of HCV to personalize the therapy for each patient, with the aim to reduce side effects, increasing the sustained virologic response rate, and to prevent the progression of the disease

Integration of the viral genome into the host cell genome: a double-edged sword

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Human Red Blood Cells Modulate Cytokine Expression in Monocytes/Macrophages Under Anoxic Conditions

In the bone marrow (BM) hematopoietic niche, the oxygen tension is usually very low. Such condition affects stem and progenitor cell proliferation and differentiation and, at cellular level regulates hematopoietic growth factors, chemokines and adhesion molecules expression. In turn, these molecules affect the proliferation and maturation of other cellular components of the niche. Due to the complexity of the system we started the in vitro investigations of the IL-6, IL-8, TNFα cytokines expression and the vascular endothelial growth factor (VEGF), considered key mediators of the hematopoietic niche, in human macrophages and macrophage cell line. Since in the niche the oxygen availability is mediated by red blood cells (RBCs), we have influenced the anoxic cell cultures by the administration of oxygenated or deoxygenated RBCs (deoxy RBCs). The results reported in this brief paper show that the presence of RBCs up-regulates IL-8 mRNA while IL-6 and VEGF mRNA expression appears down-regulated. This does not occur when deoxy RBCs are used. Moreover, it appears that the administration of RBCs leads to an increase of TNFα expression levels in MonoMac 6 (MM6). Interestingly, the modulation of these factors likely occurs in a hypoxia-inducible factor-1α (HIF-1α) independent manner. Considering the role of oxygen in the hematopoietic niche further studies should explore these preliminary observations in more details

Objeto e Correlato Intencional: De Brentano a Marty

The aim of this article is to amend some misunderstandings about Franz Brentano's thesis of intentionality, defending a different interpretation from the current one about the nature of intentional object and intentional correlate, and proposing an analysis of the origin of this conceptual confusion. The main problem lies in his student Anton Marty's interpretation of the immanent object, paving the way for an immanentist reading of Brentano's theory of intentionality.O objetivo deste artigo é retificar alguns mal-entendidos sobre a tese da intencionalidade de Franz Brentano, defendendo uma interpretação diferente da interpretação atual acerca da natureza do objeto intencional e do correlato intencional e propondo uma análise da origem desta confusão conceptual: o problema major está na interpretação que seu aluno Anton Marty faz do objeto imanente, abrindo caminho para uma leitura imanentista da teoria da intencionalidade de Brentano

Archaeometric Classification of Scattered Marble Fragments to Help the Reconstruction of Statues

A multi-technique approach combining petrographic, cathodoluminescence, and stable isotope analyses is commonly used in provenance studies of archaeological marbles. In the present paper, this characterization approach transcends provenance, and it is applied to the reconstruction of fragmented sculptures. The potential of this novel application of archaeometric measurements is illustrated with a case study consisting in 16 scattered marble fragments retrieved from a Roman villa (Els Munts) near Tarraco (presently Northeastern Spain). The samples were grouped taking into account their similarity in quantified parameters such as the cathodoluminescence color clusters and the stable carbon and oxygen isotopic ratios. The results permitted classification of the fragments into three groups corresponding to three different statues depicting Antinous (7 fragments), Minerva goddess (4 fragments), and an undetermined character (3 fragments). Two other fragments could not be ascribed to any particular statue. The archaeometric grouping provides arguments that can be used to confirm or refute archaeological hypotheses of statue reconstructions. © 2022 by the authors

A Self-Powered Wireless Water Quality Sensing Network Enabling Smart Monitoring of Biological and Chemical Stability in Supply Systems

A smart, safe, and efficient management of water is fundamental for both developed and developing countries. Several wireless sensor networks have been proposed for real-time monitoring of drinking water quantity and quality, both in the environment and in pipelines. However, surface fouling significantly affects the long-term reliability of pipes and sensors installed in-line. To address this relevant issue, we presented a multi-parameter sensing node embedding a miniaturized slime monitor able to estimate the micrometric thickness and type of slime. The measurement of thin deposits in pipes is descriptive of water biological and chemical stability and enables early warning functions, predictive maintenance, and more efficient management processes. After the description of the sensing node, the related electronics, and the data processing strategies, we presented the results of a two-month validation in the field of a three-node pilot network. Furthermore, self-powering by means of direct energy harvesting from the water flowing through the sensing node was also demonstrated. The robustness and low cost of this solution enable its upscaling to larger monitoring networks, paving the way to water monitoring with unprecedented spatio-temporal resolution. Document type: Articl

Informe de resultados RECSO 2021/2022. Localidad Balcarce

En este informe se reportan los resultados 2021/2022 de la RECSO (Red de Evaluación de Cultivares de Soja) en la localidad de Balcarce.EEA BalcarceFil: Montoya, Marina Rosa. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria Balcarce; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Instituto de Innovación para la Producción Agropecuaria y el Desarrollo Sostenible; Argentina.Fil: Giuliano, Silvio Fabián. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria Balcarce; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Instituto de Innovación para la Producción Agropecuaria y el Desarrollo Sostenible; Argentina.Fil: Antonelli, Carlos Alberto. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria Balcarce; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Instituto de Innovación para la Producción Agropecuaria y el Desarrollo Sostenible; Argentina.Fil: Zabaleta, Mauro de Dios. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria Balcarce; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Instituto de Innovación para la Producción Agropecuaria y el Desarrollo Sostenible; Argentina

Adult IDH wild-type glioblastoma ultrastructural investigation suggests a possible correlation between morphological biomarkers and Ki-67 index

Glioblastoma is an aggressive brain tumor with an average life expectancy between 14 and 16 months after diagnosis. The Ki-67 labeling index (LI), a measure of cellular proliferation, is emerging as a prognostic marker in GBM. In this study, we investigated the ultrastructure of glioblastoma tissue from 9 patients with the same molecular profile (adult IDH wild-type glioblastoma, wild-type ATRX, and positive for TP53 expression, GFAP expression, and EGFR overexpression) to find possible ultrastructural features to be used as biomarkers and correlated with the only parameter that differs among our samples, the Ki-67 LI. Our main results were the visualization of the anatomical basis of astrocyte-endothelial cells crosstalk; the ultrastructural in situ imaging of clusters of hyperactivated microglia cells (MsEVs); the ultrastructural in situ imaging of microglia cells storing lipid vesicles (MsLVs); the ultrastructural in situ imaging of neoplastic cells mitophagy (NCsM). The statistical analysis of our data indicated that MsEVs and MsLVs correlate with the Ki-67 LI value. We can thus assume they are good candidates to be considered morphological biomarkers correlating to Ki-67 LI. The role of NCsM instead must be further evaluated. Our study findings demonstrate that by combining ultrastructural characteristics with molecular information, we can discover biomarkers that have the potential to enhance diagnostic precision, aid in treatment decision-making, identify targets for therapy, and enable personalized treatment plans tailored to each patient. However, further research with larger sample sizes is needed to validate these findings and fully utilize the potential of ultrastructural analysis in managing glioblastoma