Rilettura di un’iscrizione repubblicana dall’ager Praetutianus

Si presenta una nuova lettura di un’iscrizione di Guazzano (TE) già nota (AE 1996, 573), che ricorda la realizzazione di un’aedes e del suo arredo (signum) nell’ambito di una realtà santuariale extravicana dedicata ad una divinità ignota. Si propone l’integrazione della menzione di tre personaggi in caso nominativo, nei quali si potrebbero riconoscere i magistri di un vicus sorto nelle vicinanze (Campovalano). Il territorio potrebbe rientrare nella pertica municipalis di Interamna o della pliniana Beregra, che potrebbe essere collocata proprio in quest’area. _____________________________________________ On présente une nouvelle lecture d’une inscription de Guazzano (TE) déja connue (AE 1996, 573), qui mentionne la réalisation d’une aedes et d’un signum dans une réalité sanctuariale consacrée à une divinité inconnue. On propose l’intégration de la mention de trois personnages, dans les quels on peut reconnaître les magistri d’un vicus dans les environs (Campovalano). Le territoire pourrait être compris dans la pertica municipalis d’Interamna Praetuttiorum ou de Beregra, qui pourrait être située ici

Scrivere i pesi da telaio. La documentazione dell’Italia romana

Si espongono i primi risultati di una ricerca sui pesi da telaio iscritti dell’Italia romana che riguardano identificazione del supporto, tipi di scritture, analisi della documentazione, considerazioni sul significato e sulla destinazione del corredo epigrafico, funzione dei pesi.This study concerns the inscribed loomweights of the Roman Italy; it mainly focuses on the typological identification, the epigraphic habit and the evidences; others questions look at the readers of the inscribed loomweights

Nuove testimonianze repubblicane da Urbs Salvia

Si presentano due graffiti su ceramica a vernice nera provenienti da Urbs Salvia, verosimilmente riconducibili a individui della stessa gens, protagonisti della romanizzazione del territorio e della fondazione coloniaria di età graccana.This article concerns two graffitos inscribed on black glazed potsherds found in Urbs Salvia. Very likely from the same gens, these two individuals were involved in the romanization of the territory and the colonial foundation of the site in the Gracchan age.Si presentano due graffiti su ceramica a vernice nera provenienti da Urbs Salvia, verosimilmente riconducibili a individui della stessa gens, protagonisti della romanizzazione del territorio e della fondazione coloniaria di età graccana.

Temi iconografici nelle epigrafi funerarie: un caso di studio, la regio V, Picenum

Il contributo si propone di indagare il rapporto fra testo e immagine nell’epigrafia funeraria della regio V augustea (Picenum) in età romana, con esclusione dell’ambito cristiano. In tre sezioni distinte vengono presentati i monumenti che riproducono essi stessi nel loro complesso un’immagine, quelli in cui le immagini arricchiscono il testo come elemento simbolico e decorativo, quelli in cui l’iconografia integra il messaggio del discorso epigrafico.The paper aims to investigate the relationship between text and image in the funerary epigraphy of the Augustan regio V (Picenum) in Roman Age, with exclusion from the Christian inscriptions. In three sections are presented the monuments that are themselves a image, those in which symbolic and decorative images enhance the text, those in which the iconography complements the epigraphic message

Timing of hospital admission in labour: latent versus active phase, mode of birth and intrapartum interventions: a correlational study

Background Hospitalization of women in latent labour often leads to a cascade of unnecessary intrapartum interventions, to avoid potential disadvantages the recommendation should be to stay at home to improve women’s experience and perinatal outcomes. Aim The primary aim of this study was to investigate the association between hospital admission diagnosis (latent vs active phase) and mode of birth. The secondary aim was to explore the relationship between hospital admission diagnosis, intrapartum intervention rates and maternal/neonatal outcomes. Methods A correlational study was conducted in a large Italian maternity hospital. Data from January 2013 to December 2014 were collected from the hospital electronic records. 1.446 records of low risk women were selected. These were dichotomized into two groups based on admission diagnosis: ‘latent phase’ or ‘active phase’ of labour. Findings 52.7% of women were admitted in active labour and 47.3% in the latent phase. Women in the latent phase group were more likely to experience a caesarean section or an instrumental birth, artificial rupture of membranes, oxytocin augmentation and epidural analgesia. Admission in the latent phase was associated with higher intrapartum interventions, which were statistically correlated to the mode of birth. Conclusions Women admitted in the latent phase were more likely to experience intrapartum interventions, which increase the probability of caesarean section. Maternity services should be organized around women and families needs, providing early labour support, to enable women to feel reassured facilitating their admission in labour to avoid the cascade of intrapartum interventions which increases the risk of caesarean section

Case report: PIK3CA somatic mutation leading to Klippel Trenaunay Syndrome and multiple tumors

We report a case of Klippel Trenaunay Syndrome that was monitored both clinically and molecularly over a period of 9 years. A somatic mosaic mutation of PIK3CA (p(E545G)) was identified using both cfDNA NGS liquid biopsy and tissue biopsy. At the age of 56, due to intervening clonal mutations in PIK3CA background, she developed a squamous cell carcinoma in the right affected leg which was treated surgically. Nine years later, lung bilateral adenocarcinoma arose on PIK3CA mutated tissues supported by different clonal mutations. One year later, the patient died from metastases led by a new FGFR3 clone unresponsive to standard-of-care, immunotherapy-based. Our results highlight the presence of a molecular hallmark underlying neoplastic transformation that occurs upon an angiodysplastic process and support the view that PIK3CA mutated tissues must be treated as precancerous lesions. Importantly, they remark the effectiveness of combining cfDNA NGS liquid and tissue biopsies to monitor disease evolution as well as to identify aggressive clones targetable by tailored therapy, which is more efficient than conventional protocols

Gain- and Loss-of-Function CFTR Alleles Are Associated with COVID-19 Clinical Outcomes

Carriers of single pathogenic variants of the CFTR (cystic fibrosis transmembrane conductance regulator) gene have a higher risk of severe COVID-19 and 14-day death. The machine learning post-Mendelian model pinpointed CFTR as a bidirectional modulator of COVID-19 outcomes. Here, we demonstrate that the rare complex allele [G576V;R668C] is associated with a milder disease via a gain-of-function mechanism. Conversely, CFTR ultra-rare alleles with reduced function are associated with disease severity either alone (dominant disorder) or with another hypomorphic allele in the second chromosome (recessive disorder) with a global residual CFTR activity between 50 to 91%. Furthermore, we characterized novel CFTR complex alleles, including [A238V;F508del], [R74W;D1270N;V201M], [I1027T;F508del], [I506V;D1168G], and simple alleles, including R347C, F1052V, Y625N, I328V, K68E, A309D, A252T, G542*, V562I, R1066H, I506V, I807M, which lead to a reduced CFTR function and thus, to more severe COVID-19. In conclusion, CFTR genetic analysis is an important tool in identifying patients at risk of severe COVID-19

Le 'altre tribù' nella regio V

In seguito all’aggiornamento dei tribules della V regio augustea messo a punto dall’autrice in occasione dell XVI Rencontre di Epigrafia, organizzata a Bari nel 2009, nel presente contributo vengono raccolti e discussi i casi di individui che presentano una tribù diversa da quella predominante nelle città in cui sono attestati. Viene ripresa in esame tutta la documentazione epigrafica con l’obiettivo di chiarire le situazioni individuali e i fenomeni collettivi