Systemic vasculitides: сlinical cases

Systemic vasculitides (SV) are a group of diseases characterized by vessel wall inflammation that leads to ischemic changes in the organs and tissues, which the respective vessels supply blood to; the spectrum of the clinical manifestations of SV depends on the type, size, location of the affected vessels, and on the activity of systemic inflammation. The etiology of the majority of primary vasculitides is unknown. It is assumed that many microorganisms may initiate inflammation of vessels of various sizes, but only some forms of SV (and in some patients) can be clearly related to certain causative and/or trigger factors (drug hypersensitivity, hepatitis B virus, hepatitis C virus, etc.). The paper gives clinical examples of the timely diagnosis and treatment of 2 SV cases in young men working on the railway of the town of Ruzaevka

Genetic polymorphisms associated with the development of arrhythmic type of cardiovascular events

The review analyzes the global agenda on mutational status of genes associated with adverse cardiovascular events of arrhythmic type. Whole exome sequencing will identify a risk group for the likelihood of early or delayed cardiovascular events of arrhythmic type, especially among patients receiving anticancer therapy with cardiotoxic drugs. The dedicated up-to-date panel of genetic polymorphisms will provide an opportunity to optimize management of patients, based on not only clinical, paraclinical and anamnestic data

Evaluation of the Effectiveness of Implementation of Innovative Projects in the Steel Plant

The article Describes the essence and methods of evaluating the effectiveness of the implementation of innovative projects. The results of this work are proposals to amend the legislation of the Russian Federation related to innovation policy.Описываются суть и методы оценки эффективности внедрения инновационных проектов. Результаты данной работы – предложения по внесению изменений в законодательство РФ, связанные с инновационной политикой

НОВАЯ КУЛЬТУРА ДЛЯ САЛАТНЫХ ЛИНИЙ – РЕПА ЛИСТОВАЯ

The collaborative work on growing of leafy turnip in condition of salad production line was conducted in ООО PKF «AGROTIP». The possibility of obtaining of ecologically safety salad turnip of cv. Selekta, Sapfir, and Biryuza at hydroponic system are shown. Data of yield, productivity, and content of ascorbic acid in green leaf of turnip growing in condition of flow hydroponic system are presented. The possibilities of using of tested turnip varieties in modern agrotechnological systems are discussed.Проведены совместные исследования по выращиванию репы листовой в условиях «салатныхкомплексов» на экспериментальной базе ООО «ПКФ «АГРОТИП». Показаны возможности получения экологически безопасной салатной зелени репы листовой новых сортов Селекта, Сапфир и Бирюза на проточной гидропонике. В данных условиях растения репы за 26 суток достигали массы от 88 до 182 г, в то время как у салата это происходит за 32 суток. Наиболее быстрыми темпами роста отличались сорта Селекта и Бирюза. Оценка биохимического состава салатной зелени репы показала, что в проточной культуре содержание аскорбиновой кислоты несколько ниже по сравнению с традиционной технологией, что, однако, не снижает ценности полученной продукции, которая при этом характеризуется очень низким накоплением нитратов. Таким образом, в зимнее время за один месяц при досвечивании на линии проточной гидропоники получена экологически чистая (низкое накопление нитратов) салатная зелень листовой репы сортов Сапфир, Бирюза и Селекта, что говорит о новых возможностях использования сортов ФГБНУ ВНИИССОК в современных агротехнологиях

Taxonomic and nutrient controls on phytoplankton iron quotas in the ocean

Phytoplankton iron contents (i.e., quotas) directly link biogeochemical cycles of iron and carbon and drive patterns of nutrient limitation, recycling, and export. Ocean biogeochemical models typically assume that iron quotas are either static or controlled by dissolved iron availability. We measured iron quotas in phytoplankton communities across nutrient gradients in the Pacific Ocean and found that quotas diverged significantly in taxon-specific ways from laboratory-derived predictions. Iron quotas varied 40-fold across nutrient gradients, and nitrogen-limitation allowed diatoms to accumulate fivefold more iron than co-occurring flagellates even under low iron availability. Modeling indicates such “luxury” uptake is common in large regions of the low-iron Pacific Ocean. Among diatoms, both pennate and centric genera accumulated luxury iron, but the cosmopolitan pennate genus Pseudo-nitzschia maintained iron quotas 10-fold higher than co-occurring centric diatoms, likely due to enhanced iron storage. Biogeochemical models should account for taxonomic and macronutrient controls on phytoplankton iron quotas

Non-Enzymatic Decomposition of Collagen Fibers by a Biglycan Antibody and a Plausible Mechanism for Rheumatoid Arthritis

Rheumatoid arthritis (RA) is a systemic autoimmune inflammatory and destructive joint disorder that affects tens of millions of people worldwide. Normal healthy joints maintain a balance between the synthesis of extracellular matrix (ECM) molecules and the proteolytic degradation of damaged ones. In the case of RA, this balance is shifted toward matrix destruction due to increased production of cleavage enzymes and the presence of (autoimmune) immunoglobulins resulting from an inflammation induced immune response. Herein we demonstrate that a polyclonal antibody against the proteoglycan biglycan (BG) causes tissue destruction that may be analogous to that of RA affected tissues. The effect of the antibody is more potent than harsh chemical and/or enzymatic treatments designed to mimic arthritis-like fibril de-polymerization. In RA cases, the immune response to inflammation causes synovial fibroblasts, monocytes and macrophages to produce cytokines and secrete matrix remodeling enzymes, whereas B cells are stimulated to produce immunoglobulins. The specific antigen that causes the RA immune response has not yet been identified, although possible candidates have been proposed, including collagen types I and II, and proteoglycans (PG's) such as biglycan. We speculate that the initiation of RA associated tissue destruction in vivo may involve a similar non-enzymatic decomposition of collagen fibrils via the immunoglobulins themselves that we observe here ex vivo