Особенности организации производства радиоэлектронных изделий

Розглянуто економічні показники, що характеризують статистичний контроль якості продукції. Показано, що при досягненні високої якості доцільно відмовитись від вихідного контролю, забезпечуючи інтереси споживача поповненням партії продукції, яка поставляється, додатковими виробами або відповідним чином організованим технічним обслуговуванням виробів в процесі експлуатації.Economic indicators that characterize the statistical quality control are considered. It is shown that achieving high quality appropriate to refuse access control, ensuring the consumer replenishment supplied a lot of products with additional products or properly organized maintenance products in during exploitation.Рассмотрены экономические показатели, которые характеризуют статистический контроль качества продукции. Показано, что при достижении высокого качества целесообразно отказаться от входного контроля, обеспечивая интересы потребителя пополнением поставляемой партии продукции дополнительными изделиями или соответствующим образом организованным техническим обслуживанием изделий в процессе эксплуатации

Разработка эффективной маркетинговой стратегии ценообразования на новую промышленную продукцию

Marketing approach to industrial product pricing which takes into account presence of real consumer profits in goods has been considered in the paper. Methods of parametrical pricing that permit to calculate the price with due account of technical-and-operational indices have been analyzed. Advantages and disadvantages of these methods have been revealed. Issues concerning the application of correlation and regression pricing patterns on tractor machinery are presented in the paper. Significance of tractor parameters and procedure of their offer to the world market are studied.Рассмотрен маркетинговый подход к ценообразованию на промышленную продукцию, учитывающий наличие в товаре искомых потребительских выгод. Проведен анализ методов параметрического ценообразования, позволяющих проводить расчет цены с учетом ее технико-эксплуатационных показателей, выявлены их достоинства и недостатки. Представлены вопросы использования корреляционно-регрессионных моделей ценообразования на тракторную технику, проведен анализ значимости параметров тракторов и структуры их предложения на мировом рынке

Компьютерная система диагностирования трансмиссий мобильных машин

A new method for diagnostics of mechanical transmissions of mobile machinery is proposed in the paper. The method presupposes an application of computing equipment and its purpose is to decrease labor-consumption of diagnostics procedure and increase diagnostics efficiency.The method is based on comparison of duration of impulse periods picked up at primary transducers which are installed at transmission input and output. A signal picked up at a flywheel ring gear is taken as a reference signal.While selecting clearances of one and then the direction in speed-up - braking transmission regime changes in number of reference impulses at output provide data on angular clearance value in every gearing. As data are supplied registration and processing of results and forecasting of residual resource are to be done with the help of a program on the basis of realized algorithms for every gearing.Предложен способ диагностирования механических трансмиссий мобильных машин с применением вычислительной техники в целях снижения трудоемкости постановки диагноза, а также повышения оперативности.Способ основан на сопоставлении длительности периодов импульсов, снимаемых с первичных преобразователей, установленных на входе и выходе трансмиссии. В качестве опорного сигнала принимается сигнал, снимаемый с зубчатого венца маховика.В режиме «разгон - торможение» трансмиссии при выборе зазоров сначала одного, а затем другого направления изменение количества опорных импульсов в выходном дает информацию о величине углового зазора по каждому зубчатому зацеплению. Фиксирование и обработка результатов, а также прогнозирование остаточного ресурса по мере поступления информации происходят программно на основе реализованных алгоритмов для каждого зубчатого зацепления

Secreted Human Amyloid Precursor Protein Binds Semaphorin 3a and Prevents Semaphorin-Induced Growth Cone Collapse

The amyloid precursor protein (APP) is well known for giving rise to the amyloid-β peptide and for its role in Alzheimer's disease. Much less is known, however, on the physiological roles of APP in the development and plasticity of the central nervous system. We have used phage display of a peptide library to identify high-affinity ligands of purified recombinant human sAPPα695 (the soluble, secreted ectodomain from the main neuronal APP isoform). Two peptides thus selected exhibited significant homologies with the conserved extracellular domain of several members of the semaphorin (Sema) family of axon guidance proteins. We show that sAPPα695 binds both purified recombinant Sema3A and Sema3A secreted by transfected HEK293 cells. Interestingly, sAPPα695 inhibited the collapse of embryonic chicken (Gallus gallus domesticus) dorsal root ganglia growth cones promoted by Sema3A (Kd≤8·10−9 M). Two Sema3A-derived peptides homologous to the peptides isolated by phage display blocked sAPPα binding and its inhibitory action on Sema3A function. These two peptides are comprised within a domain previously shown to be involved in binding of Sema3A to its cellular receptor, suggesting a competitive mechanism by which sAPPα modulates the biological action of semaphorins

Immune plexins and semaphorins: old proteins, new immune functions

Plexins and semaphorins are a large family of proteins that are involved in cell movement and response. The importance of plexins and semaphorins has been emphasized by their discovery in many organ systems including the nervous (Nkyimbeng-Takwi and Chapoval, 2011; McCormick and Leipzig, 2012; Yaron and Sprinzak, 2012), epithelial (Miao et al., 1999; Fujii et al., 2002), and immune systems (Takamatsu and Kumanogoh, 2012) as well as diverse cell processes including angiogenesis (Serini et al., 2009; Sakurai et al., 2012), embryogenesis (Perala et al., 2012), and cancer (Potiron et al., 2009; Micucci et al., 2010). Plexins and semaphorins are transmembrane proteins that share a conserved extracellular semaphorin domain (Hota and Buck, 2012). The plexins and semaphorins are divided into four and eight subfamilies respectively based on their structural homology. Semaphorins are relatively small proteins containing the extracellular semaphorin domain and short intra-cellular tails. Plexins contain the semaphorin domain and long intracellular tails (Hota and Buck, 2012). The majority of plexin and semaphorin research has focused on the nervous system, particularly the developing nervous system, where these proteins are found to mediate many common neuronal cell processes including cell movement, cytoskeletal rearrangement, and signal transduction (Choi et al., 2008; Takamatsu et al., 2010). Their roles in the immune system are the focus of this review

The Unity of Microcosm and Macrocosm. A New Approach to the Solution of the Old World Outlook question

The article is dedicated to the examination of an ancient problem concerning the unity of microcosm and macrocosm. There is a new approach to its solution. It is based on the idea complementarity from the quantum physics, Curie principle (the principle of symmetry/dissymmetry) and on issues of the science of cerebral hemispheres («left brain, right brain»)

Development of the Effective Marketing Strategy of New Industrial Product Pricing

Marketing approach to industrial product pricing which takes into account presence of real consumer profits in goods has been considered in the paper. Methods of parametrical pricing that permit to calculate the price with due account of technical-and-operational indices have been analyzed. Advantages and disadvantages of these methods have been revealed. Issues concerning the application of correlation and regression pricing patterns on tractor machinery are presented in the paper. Significance of tractor parameters and procedure of their offer to the world market are studied

Composition of Hydrothermal–Catalytic Conversion Products of Asphaltite from the Spiridonovskoe Oilfield

© 2019, Pleiades Publishing, Ltd. Abstract: It has been shown that the hydrothermal–catalytic conversion of solid natural asphaltite of the Spiridonovskoe oilfield (Republic of Tatarstan) at 250°C in the presence of hematite yields liquid products with a reduced amount of resins and asphaltenes. At the same time, a dispersed phase of insoluble carburized substances of the carbene and carboid types appears in the conversion products. The structural-group and molecular compositions of oils in the liquid products of conversion, which are enriched in aromatic, polycycloaromatic, and carbonyl-containing structural units and sulfoxides according to 1H NMR and IR data, have been determined. It has been established that the molecular composition of oils from the initial asphaltite and its conversion products is almost the same, but there are changes in the relative amount of various types of compounds. A low concentration of alkanes and an increased concentration of triterpanes characterize the initial Spiridonovskoe asphaltite as a biodegraded object. In the conversion products, the relative amount of alkanes has sharply increased and the concentrations of tri- and tetracyclic aromatic hydrocarbons (HC) and dibenzothiophenes have become greater. The proportion of phenanthrenes and tetracyclic aromatic hydrocarbons has increased by factors of 9.3 and 2.6, respectively, and alkylcyclohexanes have been identified, which are absent in the original asphaltite. But the relative amount of polycyclic naphthenes (pregnanes, steranes, cheilanthanes, and hopanes) significantly decreased. The revealed differences are apparently determined by the scale of generation of these compounds by the degradation of resins and asphaltenes, in which the compounds occur as structural units of molecules or in an adsorbed and/or occluded form

Features of the change in the composition heavy oils of various types and solid asphaltite in the hydrothermal-catalytic conditions

© Published under licence by IOP Publishing Ltd. The paper reveals the distinctive features of the change in the composition heavy oils of various types and of natural bitumen- A sphaltite from the sandstones of the Permian sediments of the Spiridonovsky field in the territory of Tatarstan, in model experiments at a temperature of 250°C, characteristic for steam-thermal impact on the formation, and the pressure in the system of not more than 2 MPa. The choice of low pressure is due to the fact that bituminous rocks in the Permian sediments occur at relatively shallow depths in the near-surface deposits of the sedimentary strata, which necessitates the development of special technologies for their extraction. The experiments used natural iron oxide-hematite. As a part of the products of asphaltite conversion under the influence of hydrothermal-catalytic factors, the content of hydrocarbons almost 4-fold, the content of alcohol-benzene resins and asphaltenes decreases. The content of benzene resins increases somewhat. The composition of asphaltite proved to be less stable than of heavy oils from age-old sediments, apparently due to special conditions for the formation of its composition in natural conditions under the influence of secondary low-temperature biochemical processes that led to the accumulation of thermally unstable resinous-asphaltene components. Compared with the original asphaltite, in the products of the experiment, the content of alkanes of composition C10-C30 substantially increases with an obvious predominance of homologues with an even number of carbon atoms in the molecule. The product is characterized by a lesser degree of aromaticity and content of sulfoxide groups. The results of the studies showed the possibility of upgrading the composition of solid bitumen- A sphaltite in in situ conversion by diluting its composition with lighter newly formed hydrocarbons, due to the destruction of its high molecular weight components

Computer System For Diagnostics of Mobile Machinery Transmission

A new method for diagnostics of mechanical transmissions of mobile machinery is proposed in the paper. The method presupposes an application of computing equipment and its purpose is to decrease labor-consumption of diagnostics procedure and increase diagnostics efficiency.The method is based on comparison of duration of impulse periods picked up at primary transducers which are installed at transmission input and output. A signal picked up at a flywheel ring gear is taken as a reference signal.While selecting clearances of one and then the direction in speed-up - braking transmission regime changes in number of reference impulses at output provide data on angular clearance value in every gearing. As data are supplied registration and processing of results and forecasting of residual resource are to be done with the help of a program on the basis of realized algorithms for every gearing