Contextual and individual assessment of dental pain period prevalence in adolescents: a multilevel approach

<p>Abstract</p> <p>Background</p> <p>Despite evidence that health and disease occur in social contexts, the vast majority of studies addressing dental pain exclusively assessed information gathered at individual level.</p> <p>Objectives</p> <p>To assess the association between dental pain and contextual and individual characteristics in Brazilian adolescents. In addition, we aimed to test whether contextual Human Development Index is independently associated with dental pain after adjusting for individual level variables of socio-demographics and dental characteristics.</p> <p>Methods</p> <p>The study used data from an oral health survey carried out in São Paulo, Brazil, which included dental pain, dental exams, individual socioeconomic and demographic conditions, and Human Development Index at area level of 4,249 12-year-old and 1,566 15-year-old schoolchildren. The Poisson multilevel analysis was performed.</p> <p>Results</p> <p>Dental pain was found among 25.6% (95%CI = 24.5-26.7) of the adolescents and was 33% less prevalent among those living in more developed areas of the city than among those living in less developed areas. Girls, blacks, those whose parents earn low income and have low schooling, those studying at public schools, and those with dental treatment needs presented higher dental-pain prevalence than their counterparts. Area HDI remained associated with dental pain after adjusting for individual level variables of socio demographic and dental characteristics.</p> <p>Conclusions</p> <p>Girls, students whose parents have low schooling, those with low <it>per capita </it>income, those classified as having black skin color and those with dental treatment needs had higher dental pain prevalence than their counterparts. Students from areas with low Human Development Index had higher prevalence of dental pain than those from the more developed areas regardless of individual characteristics.</p

Canagliflozin and renal outcomes in type 2 diabetes and nephropathy

BACKGROUND Type 2 diabetes mellitus is the leading cause of kidney failure worldwide, but few effective long-term treatments are available. In cardiovascular trials of inhibitors of sodium–glucose cotransporter 2 (SGLT2), exploratory results have suggested that such drugs may improve renal outcomes in patients with type 2 diabetes. METHODS In this double-blind, randomized trial, we assigned patients with type 2 diabetes and albuminuric chronic kidney disease to receive canagliflozin, an oral SGLT2 inhibitor, at a dose of 100 mg daily or placebo. All the patients had an estimated glomerular filtration rate (GFR) of 30 to &lt;90 ml per minute per 1.73 m2 of body-surface area and albuminuria (ratio of albumin [mg] to creatinine [g], &gt;300 to 5000) and were treated with renin–angiotensin system blockade. The primary outcome was a composite of end-stage kidney disease (dialysis, transplantation, or a sustained estimated GFR of &lt;15 ml per minute per 1.73 m2), a doubling of the serum creatinine level, or death from renal or cardiovascular causes. Prespecified secondary outcomes were tested hierarchically. RESULTS The trial was stopped early after a planned interim analysis on the recommendation of the data and safety monitoring committee. At that time, 4401 patients had undergone randomization, with a median follow-up of 2.62 years. The relative risk of the primary outcome was 30% lower in the canagliflozin group than in the placebo group, with event rates of 43.2 and 61.2 per 1000 patient-years, respectively (hazard ratio, 0.70; 95% confidence interval [CI], 0.59 to 0.82; P=0.00001). The relative risk of the renal-specific composite of end-stage kidney disease, a doubling of the creatinine level, or death from renal causes was lower by 34% (hazard ratio, 0.66; 95% CI, 0.53 to 0.81; P&lt;0.001), and the relative risk of end-stage kidney disease was lower by 32% (hazard ratio, 0.68; 95% CI, 0.54 to 0.86; P=0.002). The canagliflozin group also had a lower risk of cardiovascular death, myocardial infarction, or stroke (hazard ratio, 0.80; 95% CI, 0.67 to 0.95; P=0.01) and hospitalization for heart failure (hazard ratio, 0.61; 95% CI, 0.47 to 0.80; P&lt;0.001). There were no significant differences in rates of amputation or fracture. CONCLUSIONS In patients with type 2 diabetes and kidney disease, the risk of kidney failure and cardiovascular events was lower in the canagliflozin group than in the placebo group at a median follow-up of 2.62 years

Estudo de base populacional sobre as condições periodontais e determinantes socioeconômicos em adultos residentes no município de Guarulhos (SP), Brasil, 2006 Population based study on periodontal conditions and socioeconomic determinants in adults in the city of Guarulhos (SP), Brazil, 2006

OBJETIVO: Este estudo descreveu a prevalência de condições periodontais e sua associação com variáveis demográficas, socioeconômicas e comportamentais em adultos de 35 a 44 anos residentes no município de Guarulhos, São Paulo, 2006. MÉTODOS: Foi realizado estudo transversal de base populacional com delineamento amostral por conglomerados. Os inquéritos e os exames foram realizados nos domicílios sorteados. Para avaliação da condição periodontal foi utilizado o índice Community Periodontal Index (CPI). Os dados foram apurados pelo programas EPIINFO 6 e STATA 10. Para o modelo de associação empregou-se a razão de prevalências (RP), calculada por meio de análise de regressão de Poisson, com correção para delineamento de amostras complexas e ponderação pelo peso populacional. RESULTADOS: Foram examinadas 263 pessoas em 237 domicílios. No estudo multivariado, com modelo ajustado para amostras complexas e ponderação populacional, a prevalência de sangramento gengival e cálculo dentário esteve associada significativamente ao fato de ser homem (RP=1,12, p=0,04), fumante (RP=1,11, p=0,01), ter menos de oito anos de estudo (RP=1,14, p=0,01) e não visitar o cirurgião-dentista (CD) há mais de dois anos (RP=1,19, p=0,00). Para a presença de bolsa periodontal, houve associação com adultos que relataram o hábito de fumar (RP=1,71, p=0,02) e apresentavam mais de dois anos sem frequentar o CD (RP=1,97, p=0,03). CONCLUSÃO: Houve maior prevalência (62,7%) de indivíduos com sangramento gengival e cálculo dentário em relação à presença de bolsas periodontais rasas ou profundas (26,6%); as primeiras, reversíveis, têm possibilidades de resolução por meio de procedimentos de atenção básica em saúde bucal.<br>OBJECTIVE: This study described the prevalence of periodontal conditions and assessed its association with social, economical and behavioral variables in adults aged 35 to 44 years old, residents in the city of Guarulhos, State of Sao Paulo, 2006. METHODS: This study was a population based survey with cluster sampling. Data collecting and exams were done at houses drew at random. The Community Periodontal Index was used to assess the periodontal condition. Data analysis used EPIINFO 6 and STATA 10 softwares. The assessment of association used the prevalence ratio (PR), as calculated by Poisson regression models with complex sampling and weighted sample adjustments. RESULTS: The total number of people was 263 in 237 domiciles. In the multivariate model, the prevalence of gingival bleeding and dental calculus was significantly associated to being male (PR=1.12, p=0.04), smoking (PR=1.11, p=0.01), school level of less than eight years of study (PR=1.14, p=0.01), and who have not received dental care for more than two years (PR=1.19, p<0.01). As for the presence of periodontal pocket, associated factors were smoking (PR=1.71, p=0.02) and who have not received dental care for more than 2 years (PR=1.97, p=0.03). CONCLUSION: We observed a higher prevalence (62.7%) of individuals with gingival bleeding and dental calculus in relation to the presence of shallow or deep periodontal pockets (26,6%). As shallow pockets are reversible, their treatment may be resolute in programs of primary dental care

Os meios de comunicação e a prática política The midia and political practice

Recorrendo à idéia de campo de Bourdieu busca-se demonstrar que, por forte que seja a presença dos meios de comunicação na dinâmica política contemporânea, a política não se subordina a ela, pois constitui campo específico, com regras e lógica próprias.<br>Using Bourdieu's idea of field it is shown that, however strong the presence of the communication media in contemporary political dynamics, politics is not subordinated to it but forms a specific field with its own rules and logic